A Multicomponent Reaction of Arynes, Isocyanides, and Terminal Alkynes: Highly Chemo- and Regioselective Synthesis of Polysubstituted Pyridines and Isoquinolines

2009 ◽  
Vol 121 (19) ◽  
pp. 3510-3513 ◽  
Author(s):  
Feng Sha ◽  
Xian Huang
Keyword(s):  
Multicomponent Reaction ◽  
Regioselective Synthesis ◽  
Terminal Alkynes

Acetic acid mediated regioselective synthesis of 2,4,5-trisubstituted thiazoles by a domino multicomponent reaction

2019 ◽  
Vol 43 (22) ◽  
pp. 8644-8650 ◽  
Author(s):  
Mohit Saroha ◽  
Jitender M. Khurana
Keyword(s):  
Acetic Acid ◽  
Multicomponent Reaction ◽  
Regioselective Synthesis ◽  
Domino Reaction ◽  
Thiazole Derivatives ◽  
Active Methylene

Acetic acid mediated regioselective synthesis of novel 2,4,5-trisubstituted thiazole derivatives has been reported by a domino reaction of thiosemicarbazide and aldehydes/ketones/isatin, to generate thiosemicarbazones (in situ) followed by addition of arylglyoxal and active methylene/activated C–H acids/pyrazole/indole in ethanol at 80 °C.

Regioselective synthesis of 3,4,5-trisubstituted 2-aminofurans

2014 ◽  
Vol 12 (28) ◽  
pp. 5098-5101 ◽  
Author(s):  
Thi Ngoc Tram Huynh ◽  
Pascal Retailleau ◽  
Clément Denhez ◽  
Kim Phi Phung Nguyen ◽  
Dom Guillaume
Keyword(s):  
Multicomponent Reaction ◽  
Regioselective Synthesis

Three series of methyl 5-substituted 2-aminofuran-4-keto-3-carboxylates have been prepared following a multicomponent reaction strategy by the addition of an isocyanide to 4-oxo-2-butynoate in the presence of an aldehyde.

Regioselective Synthesis of 1,2-Dihydroquinolines by a Solvent-Free MgBr2-Catalyzed Multicomponent Reaction

2013 ◽  
Vol 78 (19) ◽  
pp. 9614-9626 ◽  
Author(s):  
Rsuini U. Gutiérrez ◽  
Hans C. Correa ◽  
Rafael Bautista ◽  
José Luis Vargas ◽  
Alberto V. Jerezano ◽  
...  
Keyword(s):  
Multicomponent Reaction ◽  
Solvent Free ◽  
Regioselective Synthesis

ChemInform Abstract: Nano-Copper Catalyzed Highly Regioselective Synthesis of 2,4-Disubstituted Pyrroles from Terminal Alkynes and Isocyanides.

ChemInform ◽  
2016 ◽  
Vol 47 (1) ◽  
Author(s):  
Dipak Kumar Tiwari ◽  
Jaya Pogula ◽  
B. Sridhar ◽  
Dharmendra Kumar Tiwari ◽  
Pravin R. Likhar
Keyword(s):  
Regioselective Synthesis ◽  
Terminal Alkynes
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