Raftlike Polyvalent Inhibitors of the Anthrax Toxin: Modulating Inhibitory Potency by Formation of Lipid Microdomains

2007 ◽  
Vol 119 (13) ◽  
pp. 2257-2259 ◽  
Author(s):  
Prakash R. Rai ◽  
Arundhati Saraph ◽  
Randolph Ashton ◽  
Vincent Poon ◽  
Jeremy Mogridge ◽  
...  
Keyword(s):  
Anthrax Toxin ◽  
Inhibitory Potency ◽  
Lipid Microdomains ◽  
Polyvalent Inhibitors

Raftlike Polyvalent Inhibitors of the Anthrax Toxin: Modulating Inhibitory Potency by Formation of Lipid Microdomains

2007 ◽  
Vol 46 (13) ◽  
pp. 2207-2209 ◽  
Author(s):  
Prakash R. Rai ◽  
Arundhati Saraph ◽  
Randolph Ashton ◽  
Vincent Poon ◽  
Jeremy Mogridge ◽  
...  
Keyword(s):  
Anthrax Toxin ◽  
Inhibitory Potency ◽  
Lipid Microdomains ◽  
Polyvalent Inhibitors

Synthesis of Polyvalent Inhibitors of Controlled Molecular Weight:  Structure−Activity Relationship for Inhibitors of Anthrax Toxin

2006 ◽  
Vol 7 (7) ◽  
pp. 2082-2085 ◽  
Author(s):  
Kunal V. Gujraty ◽  
Amit Joshi ◽  
Arundhati Saraph ◽  
Vincent Poon ◽  
Jeremy Mogridge ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Structure Activity Relationship ◽  
Anthrax Toxin ◽  
Activity Relationship ◽  
Structure Activity ◽  
Weight Structure ◽  
Polyvalent Inhibitors

scholarly journals Design of Monodisperse and Well-Defined Polypeptide-Based Polyvalent Inhibitors of Anthrax Toxin

2014 ◽  
Vol 53 (31) ◽  
pp. 8037-8040 ◽  
Author(s):  
Sanket Patke ◽  
Mohan Boggara ◽  
Ronak Maheshwari ◽  
Sunit K. Srivastava ◽  
Manish Arha ◽  
...  
Keyword(s):  
Anthrax Toxin ◽  
Polyvalent Inhibitors

scholarly journals Polyvalent inhibitors of anthrax toxin that target host receptors

2006 ◽  
Vol 103 (36) ◽  
pp. 13509-13513 ◽  
Author(s):  
S. Basha ◽  
P. Rai ◽  
V. Poon ◽  
A. Saraph ◽  
K. Gujraty ◽  
...  
Keyword(s):  
Anthrax Toxin ◽  
Polyvalent Inhibitors

Design of Monodisperse and Well-Defined Polypeptide-Based Polyvalent Inhibitors of Anthrax Toxin

2014 ◽  
Vol 126 (31) ◽  
pp. 8175-8178
Author(s):  
Sanket Patke ◽  
Mohan Boggara ◽  
Ronak Maheshwari ◽  
Sunit K. Srivastava ◽  
Manish Arha ◽  
...  
Keyword(s):  
Anthrax Toxin ◽  
Polyvalent Inhibitors

Third anthrax toxin revealed

Nature ◽  
2002 ◽  
Author(s):  
Tom Clarke
Keyword(s):  
Anthrax Toxin

Heparin Counteracts the Antiaggregating Effect of Prostacyclin by Potentiating Platelet Aggregation

1983 ◽  
Vol 49 (02) ◽  
pp. 081-083 ◽  
Author(s):  
Vittorio Bertelé ◽  
Maria Carla Roncaglioni ◽  
Maria Benedetta Donati ◽  
Giovanni de Gaetano
Keyword(s):  
Platelet Aggregation ◽  
Human Platelet ◽  
Specific Interaction ◽  
Inhibitory Effect ◽  
Effective Inhibitor ◽  
Inhibitory Potency ◽  
Human Platelet Aggregation

SummaryIt has recently been reported that heparin neutralizes the inhibitory effect of prostacyclin (PGI2) on human platelet aggregation. The mechanism of this interaction has not yet been unequivocally established. We present here evidence that heparin (Liquemin Roche) does not react directly with PGI2 but counteracts its inhibitory effect by potentiating platelet aggregation. In the absence of heparin, PGI2 was a less effective inhibitor of platelet aggregation induced by the combination of ADP and serotonin than by ADP alone. Moreover, the inhibitory effect of PGI2 was similarly reduced when increasing the concentrations of ADP (in the absence of heparin). The lack of a specific interaction between heparin and PGI2 is supported by the observation that, in the presence of heparin, other prostaglandins such as PGD2 and PGE1, and a non-prostanoid compound such as adenosine also appeared to lose their inhibitory potency. It is concluded that heparin opposes platelet aggregation inhibitory effect of PGI2 by enhancement of platelet aggregation.

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