scholarly journals Snapshots of the Reaction Mechanism of Matrix Metalloproteinases

2006 ◽  
Vol 118 (47) ◽  
pp. 8120-8123 ◽  
Author(s):  
Ivano Bertini ◽  
Vito Calderone ◽  
Marco Fragai ◽  
Claudio Luchinat ◽  
Massimiliano Maletta ◽  
...  
Keyword(s):  
Reaction Mechanism ◽  
Matrix Metalloproteinases

Reaction mechanism of matrix metalloproteinases with a catalytically active zinc ion studied by the QM(DFTB)/MM simulations

2016 ◽  
Vol 26 (3) ◽  
pp. 209-211 ◽  
Author(s):  
Tatiana Vasilevskaya ◽  
Maria G. Khrenova ◽  
Alexander V. Nemukhin ◽  
Walter Thiel
Keyword(s):  
Reaction Mechanism ◽  
Matrix Metalloproteinases ◽  
Zinc Ion ◽  
Catalytically Active

scholarly journals Snapshots of the Reaction Mechanism of Matrix Metalloproteinases

2006 ◽  
Vol 45 (47) ◽  
pp. 7952-7955 ◽  
Author(s):  
Ivano Bertini ◽  
Vito Calderone ◽  
Marco Fragai ◽  
Claudio Luchinat ◽  
Massimiliano Maletta ◽  
...  
Keyword(s):  
Reaction Mechanism ◽  
Matrix Metalloproteinases

Arylation of enelactams using TIPSOTf: reaction scope and mechanistic insight

2021 ◽  
Author(s):  
Tomasz J. Idzik ◽  
Zofia M. Myk ◽  
Łukasz Struk ◽  
Magdalena Perużyńska ◽  
Gabriela Maciejewska ◽  
...  
Keyword(s):  
Reaction Mechanism ◽  
Multinuclear Nmr ◽  
Mechanistic Insight ◽  
Nmr Study ◽  
Wide Range

Triisopropylsilyltrifluoromethanesulfonate can be effectively used for the arylation of a wide range of enelactams. The multinuclear NMR study provided deep insights into the reaction mechanism.

Cytokine synergy, collagenases and cartilage collagen breakdown

2003 ◽  
Vol 70 ◽  
pp. 125-133 ◽  
Author(s):  
Tim E. Cawston ◽  
Jenny M. Milner ◽  
Jon B. Catterall ◽  
Andrew D. Rowan
Keyword(s):  
Matrix Metalloproteinases ◽  
Inflammatory Cytokines ◽  
Activator Protein 1 ◽  
Activator Protein ◽  
And Cartilage ◽  
Pro Inflammatory Cytokines

We have investigated proteinases that degrade cartilage collagen. We show that pro-inflammatory cytokines act synergistically with oncastatin M to promote cartilage collagen resorption by the up-regulation and activation of matrix metalloproteinases (MMPs). The precise mechanisms are not known, but involve the up-regulation of c-fos, which binds to MMP promoters at a proximal activator protein-1 (AP-1) site. This markedly up-regulates transcription and leads to higher levels of active MMP proteins.

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