Determination by Asymmetric Total Synthesis of the Absolute Configuration of Lucilactaene, a Cell-Cycle Inhibitor in p53-Transfected Cancer Cells

2005 ◽  
Vol 117 (20) ◽  
pp. 3170-3175 ◽  
Author(s):  
Junichiro Yamaguchi ◽  
Hideaki Kakeya ◽  
Takao Uno ◽  
Mitsuru Shoji ◽  
Hiroyuki Osada ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Total Synthesis ◽  
Cancer Cells ◽  
Absolute Configuration ◽  
Asymmetric Total Synthesis ◽  
Cell Cycle Inhibitor ◽  
A Cell ◽  
The Absolute

Determination of the Absolute Configuration of Lucilactaene, a Cell-Cycle Inhibitor in p53-Transfected Cancer Cells, by Asymmetric Total Synthesis.

ChemInform ◽  
2005 ◽  
Vol 36 (38) ◽  
Author(s):  
Junichiro Yamaguchi ◽  
Hideaki Kakeya ◽  
Takao Uno ◽  
Mitsuru Shoji ◽  
Hiroyuki Osada ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Total Synthesis ◽  
Cancer Cells ◽  
Absolute Configuration ◽  
Asymmetric Total Synthesis ◽  
Cell Cycle Inhibitor ◽  
A Cell ◽  
The Absolute

Asymmetric Total Synthesis and Determination of the Absolute Configuration of (+)-Srilankenyne via Sequence-Sensitive Halogenations Guided by Conformational Analysis

2021 ◽  
Vol 23 (4) ◽  
pp. 1321-1326
Author(s):  
Hongjun Jang ◽  
Soo Yeon Kwak ◽  
Dongjoo Lee ◽  
Juan V. Alegre-Requena ◽  
Hyoungsu Kim ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Conformational Analysis ◽  
Absolute Configuration ◽  
Asymmetric Total Synthesis ◽  
The Absolute

Asymmetric synthesis of machilin C and its analogue

2010 ◽  
Vol 64 (5) ◽  
Author(s):  
Yamu Xia ◽  
Wei Wang
Keyword(s):  
Total Synthesis ◽  
Asymmetric Synthesis ◽  
Absolute Configuration ◽  
Asymmetric Induction ◽  
Mitsunobu Reaction ◽  
Asymmetric Total Synthesis ◽  
Twelve Steps ◽  
The Absolute

AbstractFull details of the asymmetric total synthesis of erythro-8-O-4′-neolignan, machilin C, and its analogue perseal A are reported. The synthesis was involved in the Sharpless dihydroxylation reaction that occurred with excellent asymmetric induction, and the Mitsunobu reaction which occurred with inversion of the absolute configuration from the threo to the erythro isomer. The synthesis was achieved from simple vanillin in eight to twelve steps.

Total Synthesis of Lucilactaene, A Cell Cycle Inhibitor Active in p53-Inactive Cells

2005 ◽  
Vol 127 (46) ◽  
pp. 16038-16039 ◽  
Author(s):  
Robert S. Coleman ◽  
Matthew C. Walczak ◽  
Erica L. Campbell
Keyword(s):  
Cell Cycle ◽  
Total Synthesis ◽  
Cell Cycle Inhibitor ◽  
A Cell

scholarly journals A new phenylethyl alkyl amide from the Ambrostoma quadriimpressum Motschulsky

2011 ◽  
Vol 7 ◽  
pp. 1342-1346 ◽  
Author(s):  
Guolei Zhao ◽  
Chao Yang ◽  
Bing Li ◽  
Wujiong Xia
Keyword(s):  
Total Synthesis ◽  
Glutamic Acid ◽  
Absolute Configuration ◽  
Aliphatic Chain ◽  
Asymmetric Total Synthesis ◽  
Selective Protection ◽  
Wittig Olefination ◽  
The Absolute ◽  
Hydroxy Groups ◽  
Alkyl Amide

A new phenylethyl alkyl amide, (10R)-10-hydroxy-N-phenethyloctadecanamide (1), was isolated from the beetle Ambrostoma quadriimpressum Motschulsky. The structure of the amide was determined by NMR and MS. The absolute configuration of compound 1 was confirmed by an asymmetric total synthesis, which was started from L-glutamic acid. The construction of the aliphatic chain was accomplished by the selective protection of the hydroxy groups and two-time implementation of the Wittig olefination reaction.

Asymmetric Total Synthesis and Revision of the Absolute Configuration of 4-Keto-Clonostachydiol

2009 ◽  
Vol 74 (10) ◽  
pp. 3930-3932 ◽  
Author(s):  
Junjie Han ◽  
Yingpeng Su ◽  
Tuo Jiang ◽  
Yanfen Xu ◽  
Xing Huo ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Absolute Configuration ◽  
Asymmetric Total Synthesis ◽  
The Absolute
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