Presymptomatic and early detection in Huntington's disease

1980 ◽  
Vol 8 (4) ◽  
pp. 343-347 ◽  
Author(s):  
Harold L. Klawans ◽  
Christopher G. Goetz ◽  
Stuart Perlik
Keyword(s):  
Early Detection ◽  
Huntington's Disease ◽  
Huntington’S Disease

[P-058]: Early detection of dementia in Huntington's disease: The Predict-HD study

2005 ◽  
Vol 1 ◽  
pp. S26-S26
Author(s):  
Jane S. Paulsen ◽  
Julie C. Stout ◽  
Elizabeth Aylward ◽  
Karl Kieburtz ◽  
Douglas Langbehn ◽  
...  
Keyword(s):  
Early Detection ◽  
Huntington's Disease ◽  
Huntington’S Disease

scholarly journals Early Detection of Apathetic Phenotypes in Huntington’s Disease Knock-in Mice Using Open Source Tools

2017 ◽  
Author(s):  
Shawn Minnig ◽  
Robert M. Bragg ◽  
Hardeep S. Tiwana ◽  
Wes T. Solem ◽  
William S. Hovander ◽  
...  
Keyword(s):  
Early Detection ◽  
Huntington's Disease ◽  
Open Source ◽  
Huntington’S Disease ◽  
Fixed Ratio ◽  
Noisy Data ◽  
Progressive Ratio ◽  
Phenotypic Rescue ◽  
Preclinical Work ◽  
Normal Performance

AbstractApathy is one of the most prevalent and progressive psychiatric symptom in Huntington’s disease (HD) patients. However, preclinical work in HD mouse models tend to focus on molecular and motor, rather than affective, phenotypes. Measuring behavior in mice often produces noisy data and requires large cohorts to detect phenotypic rescue with appropriate power. The operant equipment necessary for measuring affective phenotypes is typically expensive, proprietary to commercial entities, and bulky which can render adequately sized mouse cohorts as cost-prohibitive. Thus, we describe here a home-built open-source alternative to commercial hardware that is reliable, scalable, and reproducible. Using off-the-shelf hardware, we adapted and built several of the rodent operant buckets (ROBucket) designed to test HttQ111/+ mice for attention deficits in fixed ratio (FR) and progressive ratio (PR) tasks. We find that, despite normal performance in reward attainment in the FR task, HttQ111/+ mice exhibit reduced PR performance at 9-11 months of age, suggesting motivational deficits. We replicated this in two independent cohorts, which demonstrates the reliability and utility of both the apathetic phenotype, and these ROBuckets, for preclinical HD studies.

scholarly journals Early detection of Huntington’s disease

2010 ◽  
Vol 5 (1) ◽  
pp. 85-104 ◽  
Author(s):  
Jane S Paulsen
Keyword(s):  
Early Detection ◽  
Huntington's Disease ◽  
Huntington’S Disease

scholarly journals Early Detection of Apathetic Phenotypes in Huntington’s Disease Knock-in Mice Using Open Source Tools

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Shawn Minnig ◽  
Robert M. Bragg ◽  
Hardeep S. Tiwana ◽  
Wes T. Solem ◽  
William S. Hovander ◽  
...  
Keyword(s):  
Early Detection ◽  
Huntington's Disease ◽  
Open Source ◽  
Huntington’S Disease

WAIS-R Features of Preclinical Huntington’s Disease: Implications for Early Detection

2010 ◽  
Vol 29 (4) ◽  
pp. 342-350 ◽  
Author(s):  
Tarja-Brita Robins Wahlin ◽  
Maria U. Larsson ◽  
Mary A. Luszcz ◽  
Gerard J. Byrne
Keyword(s):  
Early Detection ◽  
Huntington's Disease ◽  
Huntington’S Disease

Poster 7: Memory for Temporal Sequences for the Early Detection of Cognitive Changes in Preclinical Huntington's Disease

2009 ◽  
Vol 6 (1) ◽  
pp. 206-206
Author(s):  
E PIROGOVSKY ◽  
B BARTLETT ◽  
A CALLAZO ◽  
J GOLDSTEIN ◽  
G PEAVY ◽  
...  
Keyword(s):  
Early Detection ◽  
Huntington's Disease ◽  
Huntington’S Disease ◽  
Cognitive Changes ◽  
Temporal Sequences
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