Degradation of myelin basic protein by cerebrospinal fluid: Preservation of antigenic determinants under physiological conditions

1979 ◽  
Vol 6 (6) ◽  
pp. 474-482 ◽  
Author(s):  
Ellsworth C. Alvord ◽  
Sarka Hruby ◽  
Linda R. Sires
Keyword(s):  
Cerebrospinal Fluid ◽  
Myelin Basic Protein ◽  
Basic Protein ◽  
Antigenic Determinants ◽  
Physiological Conditions ◽  
Fluid Preservation

Cerebrospinal fluid myelin basic protein as predictive marker of demyelination in AIDS dementia complex

1992 ◽  
Vol 36 (2-3) ◽  
pp. 251-254 ◽  
Author(s):  
G.M. Liuzzi ◽  
C.M. Mastroianni ◽  
V. Vullo ◽  
E. Jirillo ◽  
S. Delia ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Myelin Basic Protein ◽  
Basic Protein ◽  
Predictive Marker ◽  
Aids Dementia Complex ◽  
Aids Dementia

Oligoclonal IgGs against DNA, Histones, and Myelin Basic Protein in the Cerebrospinal Fluid of Patients with Multiple Sclerosis

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Kostrikina IA ◽  
◽  
Granieri E ◽  
Nevinsky GA ◽  
◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Myelin Basic Protein ◽  
Basic Protein ◽  
Main Role ◽  
Barr Virus ◽  
The Central Nervous System ◽  
Epstein Barr ◽  
Ms Pathogenesis ◽  
Myelin Proteolipid

Multiple Sclerosis (MS) is known as a chronic demyelinating pathology of the central nervous system. The most accepted MS pathogenesis theory assigns the main role to demyelination of myelin-proteolipid shells due to inflammationrelated with autoimmune reactions. One of the features of MS patients is the enhanced synthesis of oligoclonal IgGs in the bone marrow Cerebrospinal Fluid (CSF). By antigen-specific immunoblotting after isoelectrofocusing of IgGs, oligoclonal IgGs in CSF of MS patients were revealed only against the components of Epstein-Barr virus and Chlamydia. However, there was still unknown to which human auto-antigens in MS patients oligoclonal IgGs may be produced. Here it was first shown that in the CSF of a narrow percentage of MS patients, oligoclonal IgGs are produced against their own antigens: DNA (24% patients), histones (20%), and myelin basic protein (12%). At the same time, the CSF of MS patients contains a very large amount of auto-IgGs-abzymes that hydrolyze DNA, histones, and myelin basic protein, which during isofocusing, are distributed throughout the gel from pH 3 to 10. It is concluded that these multiple IgGs-abzymes, which are dangerous to humans since stimulate development of MS, in the main are non-oligoclonal antibodies.

Diagnostic Value of Myelin Basic Protein in Cerebrospinal Fluid

1980 ◽  
pp. 161-167
Author(s):  
S. R. Cohen ◽  
M. J. Brune ◽  
R. M. Herndon ◽  
G. M. McKhann
Keyword(s):  
Cerebrospinal Fluid ◽  
Myelin Basic Protein ◽  
Basic Protein ◽  
Diagnostic Value
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