Progressive dialysis encephalopathy. Role of aluminum toxicity

1979 ◽  
Vol 6 (1) ◽  
pp. 88-88 ◽  
Author(s):  
Michel Poisson ◽  
Ragay Mashaly ◽  
Bernard Lafforgue
Keyword(s):  
Aluminum Toxicity ◽  
Dialysis Encephalopathy ◽  
Progressive Dialysis Encephalopathy

Citrate chelation as a potential mechanism against aluminum toxicity in cells: the role of calmodulin

1985 ◽  
Vol 63 (11) ◽  
pp. 1167-1175 ◽  
Author(s):  
Charles G. Suhayda ◽  
Alfred Haug
Keyword(s):  
Circular Dichroism ◽  
Conceptual Understanding ◽  
Aluminum Toxicity ◽  
Hydrophobic Surface ◽  
Native Structure ◽  
Calcium Calmodulin Dependent ◽  
Α Helix ◽  
Kinetics Of ◽  
Circular Dichroïsm

At a molar excess of [citrate]/[aluminum], this organic acid can protect calmodulin from aluminum binding if the metal is presented to the protein in stoichiometric micromolar quantities, as judged by fluorescence and circular dichroism spectroscopy. Similar citrate concentrations are also capable of fully restoring calmodulin's hydrophobic surface exposure to that of the native protein when calmodulin was initially damaged by aluminum binding. Fluoride anions are equally effective in restoring calmodulin's native structure as determined by fluorescence spectroscopy. Measurements of the kinetics of citrate-mediated aluminum removal also indicated that the metal ions are completely removed from calmodulin, consistent with results derived from atomic absorption experiments. On the other hand, results from circular dichroism studies indicated that citrate-mediated aluminum removal from calmodulin can only partially restore the α-helix content to that originally present in apocalmodulin or in calcium–calmodulin, dependent upon the absence or presence of calcium ions. The results that chelators like citrate can protect calmodulin from aluminum injury may provide a conceptual understanding of physiological observations regarding aluminum-tolerant plant species which are generally rich in certain organic acids.

scholarly journals Possible Role of Root Border Cells in Detection and Avoidance of Aluminum Toxicity

2001 ◽  
Vol 125 (4) ◽  
pp. 1978-1987 ◽  
Author(s):  
Susan C. Miyasaka ◽  
Martha C. Hawes
Keyword(s):  
Aluminum Toxicity ◽  
Border Cells ◽  
Root Border Cells

Secondary Mania as a Presentation of Progressive Dialysis Encephalopathy

1983 ◽  
Vol 171 (3) ◽  
pp. 193-195 ◽  
Author(s):  
ROBERT A. JACK ◽  
NOEL T. RIVERS-BULKELEY ◽  
PAULINE L. RABIN
Keyword(s):  
Dialysis Encephalopathy ◽  
Secondary Mania ◽  
Progressive Dialysis Encephalopathy
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