scholarly journals Subcortical volumes as early predictors of fatigue in multiple sclerosis

2021 ◽  
Author(s):  
Vinzenz Fleischer ◽  
Dumitru Ciolac ◽  
Gabriel Gonzalez‐Escamilla ◽  
Matthias Grothe ◽  
Sebastian Strauss ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Early Predictors ◽  
Subcortical Volumes

Early predictors of multiple sclerosis after a typical clinically isolated syndrome

2014 ◽  
Vol 20 (13) ◽  
pp. 1721-1726 ◽  
Author(s):  
Aurélie Ruet ◽  
Georgina Arrambide ◽  
Bruno Brochet ◽  
Cristina Auger ◽  
Eva Simon ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
At Risk ◽  
High Specificity ◽  
Clinically Isolated Syndrome ◽  
Oligoclonal Bands ◽  
Mcdonald Criteria ◽  
Early Predictors ◽  
Patients At Risk ◽  
Magnetic Resonance Imaging Mri ◽  
Periventricular Lesions

Background: The 2010 McDonald criteria allow diagnosing multiple sclerosis (MS) with one magnetic resonance imaging (MRI) scan. Nevertheless, not all patients at risk fulfil criteria at baseline. Other predictive factors (PFs) are: age ≤40 years, positive oligoclonal bands (OBs), and ≥3 periventricular lesions. Objective: The purpose of this study was to evaluate the 2010 McDonald criteria performance and to assess other PFs in patients without dissemination in space (DIS). Methods: Patients with clinically isolated syndrome (CIS) underwent baseline MRI and OB determination with clinical and radiological follow-up. Adjusted hazard ratios (aHRs) for clinically definite MS were estimated for DIS, dissemination in time (DIT), and DIS+DIT. Diagnostic properties at two years were calculated. In cases without DIS, combinations of ≥2 PFs were assessed. Results: A total of 652 patients were recruited; aHRs were 3.8 (2.5–5.8) for DIS, 4.2 (1.9–9.2) for DIT, and 8.6 (5.4–13.8) for DIS+DIT. Sensitivities were 69.6%, 42.3%, and 36.4%, and specificities were 67.3%, 87.9%, and 90.2%, respectively. In patients without DIS, aHRs varied between 2.7–5.5 and specificities ranged from 73.5–89.7% for PF combinations. Conclusion: The high specificity of the 2010 McDonald criteria is confirmed. In patients without DIS, PF combinations could be helpful in identifying those at risk for MS.

Early Predictors of Conversion to Secondary Progressive Multiple Sclerosis

2021 ◽  
pp. 103115
Author(s):  
Mahdi Barzegar ◽  
Soroush Najdaghi ◽  
Alireza Afshari-Safavi ◽  
Nasim Nehzat ◽  
Omid Mirmosayyeb ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Progressive Multiple Sclerosis ◽  
Secondary Progressive Multiple Sclerosis ◽  
Secondary Progressive ◽  
Early Predictors

Parity is associated with a longer time to reach irreversible disability milestones in women with multiple sclerosis

2014 ◽  
Vol 21 (10) ◽  
pp. 1291-1297 ◽  
Author(s):  
S Masera ◽  
P Cavalla ◽  
L Prosperini ◽  
A Mattioda ◽  
CR Mancinelli ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Regression Models ◽  
Cox Regression ◽  
Disability Progression ◽  
Childbearing Age ◽  
Early Predictors ◽  
Nulliparous Women ◽  
Long Term Effect ◽  
Immunological Effect

Background: Multiple sclerosis (MS) frequently affects women of childbearing age. While short-term effects of pregnancy on MS course are well-known, whether pregnancy may influence long-term disability progression is debated. Methods: A two-centre retrospective study to investigate long-term effect of pregnancy on disability was performed in a population of MS women. Survival analyses and multivariate Cox proportional regression models (including early predictors of MS severity and exposure to disease-modifying treatments) were performed to compare time to reach well-established disability milestones in nulliparous women and in those with pregnancies after MS onset (‘parous’). Women with pregnancies before MS onset were excluded from analyses as they represent a heterogeneous group. Results: Data about 445 women (261 nulliparous, 184 ‘parous’) were analysed. A longer time to reach Expanded Disability Status Scale (EDSS) 4.0 and 6.0 was observed in parous women; Cox regression models revealed a lower risk for ‘parous’ than nulliparous women in reaching EDSS 4.0 and 6.0 (HR = 0.552, p = 0.008 and HR = 0.422, p = 0.012 respectively). Conclusion: Our findings suggest that pregnancy after MS onset is associated with a slower long-term disability progression. Whether this represents a biological/immunological effect, or reflects a higher propensity toward childbearing in women with milder disease, it remains uncertain deserving further investigations.

Early predictors of 9‐year disability in pediatric multiple sclerosis

2021 ◽  
Author(s):  
Ermelinda De Meo ◽  
Raffaello Bonacchi ◽  
Lucia Moiola ◽  
Bruno Colombo ◽  
Francesca Sangalli ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Pediatric Multiple Sclerosis ◽  
Early Predictors

Early predictors of non-response to interferon in multiple sclerosis

2012 ◽  
Vol 126 (6) ◽  
pp. 390-397 ◽  
Author(s):  
D. Horakova ◽  
T. Kalincik ◽  
O. Dolezal ◽  
J. Krasensky ◽  
M. Vaneckova ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Early Predictors

Early predictors of rapidly evolving multiple sclerosis: A case report

2017 ◽  
Vol 307 ◽  
pp. 42-46
Author(s):  
Kryshani T.M. Fernando ◽  
Michael James
Keyword(s):  
Multiple Sclerosis ◽  
Case Report ◽  
Early Predictors

scholarly journals Predicting the profile of increasing disability in multiple sclerosis

2018 ◽  
Vol 25 (9) ◽  
pp. 1306-1315 ◽  
Author(s):  
Valentina Tomassini ◽  
Fulvia Fanelli ◽  
Luca Prosperini ◽  
Raffaella Cerqua ◽  
Paola Cavalla ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Disease Activity ◽  
Early Recognition ◽  
Early Predictors ◽  
Disability Status ◽  
Preserve Function ◽  
Magnetic Resonance Imaging Mri ◽  
Individual Disease ◽  
Delay Progression

Background: Effective therapeutic strategies to preserve function and delay progression in multiple sclerosis (MS) require early recognition of individual disease trajectories. Objectives: To determine the profiles of disability evolution, identify their early predictors and develop a risk score of increasing disability. Methods: We analysed demographic, clinical and magnetic resonance imaging (MRI) data from patients with relapsing MS, Expanded Disability Status Scale (EDSS) score of 3.0–4.0 and follow-up ≥ 2 years. Attaining EDSS = 6.0 defined increasing disability; relapses and/or MRI defined disease activity. Results: In total, 344 out of 542 (63.5%) patients reached EDSS ≥ 6.0; of these, 220 (64.0%) showed disease activity. In patients with activity, the number of relapses before reaching EDSS 3.0–4.0 predicted increasing disability; age > 45 at baseline predicted increasing disability without activity. Combining age and number of relapses increased the risk of and shortened the time to EDSS = 6.0. Conclusion: Increasing disability is frequently associated with persistent activity. The high number of relapses identifies early those patients worsening in the presence of activity. Age predicts increasing disability in the absence of activity. The presence of both factors increases the risk of developing severe disability. As this study likely describes the transition to progression, our findings contribute to improving patient management and stratification in trials on progressive MS.

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