scholarly journals Optimal surgical extent for memory and seizure outcome in temporal lobe epilepsy

2021 ◽  
Author(s):  
Daichi Sone ◽  
Maria Ahmad ◽  
Pamela J. Thompson ◽  
Sallie Baxendale ◽  
Sjoerd B. Vos ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Seizure Outcome ◽  
Surgical Extent

scholarly journals Temporal pole abnormalities detected by 3 T MRI in temporal lobe epilepsy due to hippocampal sclerosis: No influence on seizure outcome after surgery

Seizure ◽  
2017 ◽  
Vol 48 ◽  
pp. 74-78 ◽  
Author(s):  
Sara Casciato ◽  
Angelo Picardi ◽  
Alfredo D’Aniello ◽  
Marco De Risi ◽  
Giovanni Grillea ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Hippocampal Sclerosis ◽  
Seizure Outcome ◽  
Temporal Pole

Do psychiatric comorbidities predict postoperative seizure outcome in temporal lobe epilepsy surgery?

2009 ◽  
Vol 14 (3) ◽  
pp. 529-534 ◽  
Author(s):  
Ricardo Guarnieri ◽  
Roger Walz ◽  
Jaime E.C. Hallak ◽  
Érica Coimbra ◽  
Edna de Almeida ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Epilepsy Surgery ◽  
Seizure Outcome ◽  
Psychiatric Comorbidities ◽  
Postoperative Seizure

Association Between Anatomical Location of Surgically Induced Lesions and Postoperative Seizure Outcome in Temporal Lobe Epilepsy

Neurology ◽  
2021 ◽  
pp. 10.1212/WNL.0000000000013033
Author(s):  
Ezequiel Gleichgerrcht ◽  
Daniel L. Drane ◽  
Simon Sean Keller ◽  
Kathryn A. Davis ◽  
Robert Gross ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Anterior Commissure ◽  
Piriform Cortex ◽  
Seizure Outcome ◽  
Seizure Freedom ◽  
Anatomical Location ◽  
Surgical Interventions ◽  
Postoperative Seizure ◽  
Promising Source

Objective:To determine the association between surgical lesions of distinct grey and white structures and connections with favorable post-operative seizure outcomes.Methods:Patients with drug-resistant temporal lobe epilepsy (TLE) from three epilepsy centers were included. We employed a voxel-based and connectome-based mapping approach to determine the association between favorable outcomes and surgery-induced temporal lesions. Analyses were conducted controlling for multiple confounders, including total surgical resection/ablation volume, hippocampal volumes, side of surgery, and site where the patient was treated.Results:The cohort included 113 patients with TLE [54 women; 86 right-handed; 16.5 (SD = 11.9) age at seizure onset, 54.9% left] who were 61.1% free of disabling seizures (Engel class 1) at follow-up. Postoperative seizure freedom in TLE was associated with 1) surgical lesions that targeted the hippocampus as well as the amygdala-piriform cortex complex and entorhinal cortices; 2) disconnection of temporal, frontal, and limbic regions through loss of white matter tracts within the uncinate fasciculus, anterior commissure, and fornix; and 3) functional disconnection of the frontal (superior and middle frontal gyri, orbitofrontal region) and temporal (superior and middle pole) lobes.Conclusions:Better postoperative seizure freedom are associated with surgical lesions of specific structures and connections throughout the temporal lobes. These findings shed light on the key components of epileptogenic networks in TLE and constitute a promising source of new evidence for future improvements in surgical interventions.Classification of Evidence:This study provides Class II evidence that for patients with temporal lobe epilepsy, postoperative seizure freedom is associated with surgical lesions of specific temporal lobe structures and connections.

scholarly journals The role of presurgical EEG parameters and of reoperation for seizure outcome in temporal lobe epilepsy

Seizure ◽  
2017 ◽  
Vol 51 ◽  
pp. 174-179 ◽  
Author(s):  
B. Schmeiser ◽  
J. Zentner ◽  
B.J. Steinhoff ◽  
A. Brandt ◽  
A. Schulze-Bonhage ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Seizure Outcome

Reassessing the impact of intraoperative electrocorticography on postoperative outcome of patients undergoing standard temporal lobectomy for MRI-negative temporal lobe epilepsy

2020 ◽  
Vol 132 (2) ◽  
pp. 605-614 ◽  
Author(s):  
Sanjeet S. Grewal ◽  
Mohammed Ali Alvi ◽  
William J. Perkins ◽  
Gregory D. Cascino ◽  
Jeffrey W. Britton ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Univariate Analysis ◽  
Temporal Lobectomy ◽  
Seizure Outcome ◽  
Incomplete Resection ◽  
Seizure Recurrence ◽  
Cox Regression Analysis ◽  
Epileptiform Discharges ◽  
The Impact

OBJECTIVEAlmost 30% of the patients with suspected temporal lobe epilepsy (TLE) have normal results on MRI. Success rates for resection of MRI-negative TLE are less favorable, ranging from 36% to 76%. Herein the authors describe the impact of intraoperative electrocorticography (ECoG) augmented by opioid activation and its effect on postoperative seizure outcome.METHODSAdult and pediatric patients with medically resistant MRI-negative TLE who underwent standardized ECoG at the time of their elective anterior temporal lobectomy (ATL) with amygdalohippocampectomy between 1990 and 2016 were included in this study. Seizure recurrence comprised the primary outcome of interest and was assessed using Kaplan-Meier and multivariable Cox regression analysis plots based on distribution of interictal epileptiform discharges (IEDs) recorded on scalp electroencephalography, baseline and opioid-induced IEDs on ECoG, and extent of resection.RESULTSOf the 1144 ATLs performed at the authors’ institution between 1990 and 2016, 127 (11.1%) patients (81 females) with MRI-negative TLE were eligible for this study. Patients with complete resection of tissue generating IED recorded on intraoperative ECoG were less likely to have seizure recurrence compared to those with incomplete resection on univariate analysis (p < 0.05). No difference was found in seizure recurrence between patients with bilateral independent IEDs and unilateral IEDs (p = 0.15), presence or absence of opioid-induced epileptiform activation (p = 0.61), or completeness of resection of tissue with opioid-induced IEDs on intraoperative ECoG (p = 0.41).CONCLUSIONSThe authors found that incomplete resection of IED-generating tissue on intraoperative ECoG was associated with an increased chance of seizure recurrence. However, they found that induction of epileptiform activity with intraoperative opioid activation did not provide useful intraoperative data predictive of improving operative results for temporal lobectomy in MRI-negative epilepsy.

Extratemporal hypometabolism on FDG PET in temporal lobe epilepsy as a predictor of seizure outcome after temporal lobectomy

2003 ◽  
Vol 30 (4) ◽  
pp. 581-587 ◽  
Author(s):  
Joon Young Choi ◽  
Sun Jung Kim ◽  
Seung Bong Hong ◽  
Dae Won Seo ◽  
Seung Chyul Hong ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Fdg Pet ◽  
Temporal Lobectomy ◽  
Seizure Outcome

scholarly journals Hippocampal internal architecture and postoperative seizure outcome in temporal lobe epilepsy due to hippocampal sclerosis

Seizure ◽  
2016 ◽  
Vol 35 ◽  
pp. 65-71 ◽  
Author(s):  
Samia Elkommos ◽  
Bernd Weber ◽  
Pitt Niehusmann ◽  
Elisa Volmering ◽  
Mark P. Richardson ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Hippocampal Sclerosis ◽  
Seizure Outcome ◽  
Postoperative Seizure ◽  
Internal Architecture

scholarly journals Prediction of post-surgical seizure outcome in left mesial temporal lobe epilepsy

2013 ◽  
Vol 2 ◽  
pp. 903-911 ◽  
Author(s):  
Delia-Lisa Feis ◽  
Jan-Christoph Schoene-Bake ◽  
Christian Elger ◽  
Jan Wagner ◽  
Marc Tittgemeyer ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Temporal Lobe ◽  
Mesial Temporal Lobe Epilepsy ◽  
Seizure Outcome ◽  
Mesial Temporal Lobe
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