scholarly journals Complement activation is a prominent feature of MOGAD

2021 ◽  
Author(s):  
Christian W. Keller ◽  
Joseph A. Lopez ◽  
Eva‐Maria Wendel ◽  
Sudarshini Ramanathan ◽  
Catharina C. Gross ◽  
...  
Keyword(s):  
Complement Activation ◽  
Prominent Feature

The Morphology of Vacuolated Cells in the Liver Following Administration of Vitamin A.

1973 ◽  
Vol 31 ◽  
pp. 408-409
Author(s):  
Odell T. Minick ◽  
Hidejiro Yokoo ◽  
Fawzia Batti
Keyword(s):  
Electron Microscopy ◽  
Body Weight ◽  
Vitamin A ◽  
Light And Electron Microscopy ◽  
Liver Cells ◽  
Prominent Feature ◽  
Vascular Space ◽  
Vacuolated Cell ◽  
Vacuolated Cells ◽  
Vacuolated Cytoplasm

Vacuolated cells in the liver of young rats were studied by light and electron microscopy following the administration of vitamin A (200 units per gram of body weight). Their characteristics were compared with similar cells found in untreated animals.In rats given vitamin A, cells with vacuolated cytoplasm were a prominent feature. These cells were found mostly in a perisinusoidal location, although some appeared to be in between liver cells (Fig. 1). Electron microscopy confirmed their location in Disse's space adjacent to the sinusoid and in recesses between liver cells. Some appeared to be bordering the lumen of the sinusoid, but careful observation usually revealed a tenuous endothelial process separating the vacuolated cell from the vascular space. In appropriate sections, fenestrations in the thin endothelial processes were noted (Fig. 2, arrow).

The Mechanism of Platelet Aggregation Induced by HLA-Related Antibodies

1996 ◽  
Vol 76 (05) ◽  
pp. 774-779 ◽  
Author(s):  
John T Brandt ◽  
Carmen J Julius ◽  
Jeanne M Osborne ◽  
Clark L Anderson
Keyword(s):  
Platelet Aggregation ◽  
Platelet Activation ◽  
Complement Activation ◽  
Thromboembolic Disease ◽  
Clinical Samples ◽  
Hla Antigen ◽  
Aggregation Response ◽  
Immune Mediated ◽  
Dependent Pathway

SummaryImmune-mediated platelet activation is emerging as an important pathogenic mechanism of thrombosis. In vitro studies have suggested two distinct pathways for immune-mediated platelet activation; one involving clustering of platelet FcyRIIa, the other involving platelet-associated complement activation. HLA-related antibodies have been shown to cause platelet aggregation, but the mechanism has not been clarified. We evaluated the mechanism of platelet aggregation induced by HLA-related antibodies from nine patients. Antibody to platelet FcyRIIa failed to block platelet aggregation with 8/9 samples, indicating that engagement of platelet FcyRIIa is not necessary for the platelet aggregation induced by HLA-related antibodies. In contrast, platelet aggregation was blocked by antibodies to human C8 (5/7) or C9 (7/7). F(ab’)2 fragments of patient IgG failed to induce platelet activation although they bound to HLA antigen on platelets. Intact patient IgG failed to aggregate washed platelets unless aged serum was added. The activating IgG could be adsorbed by incubation with lymphocytes and eluted from the lymphocytes. These results indicate that complement activation is involved in the aggregation response to HLA-related antibodies. This is the first demonstration of complement-mediated platelet aggregation by clinical samples. Five of the patients developed thrombocytopenia in relationship to blood transfusion and two patients developed acute thromboembolic disease, suggesting that these antibodies and the complement-dependent pathway of platelet aggregation may be of clinical significance.

Duality, Opposition and Typology in the Qur'an: The Apocalyptic Substrate

2008 ◽  
Vol 10 (2) ◽  
pp. 23-49 ◽  
Author(s):  
Todd Lawson
Keyword(s):  
Structural Elements ◽  
Prominent Feature ◽  
Apocalyptic Literature ◽  
Cultural Traditions ◽  
Bona Fide

This article highlights two features of Qur'anic style and content: duality/opposition and typological figuration, which can be seen as providing a continuous and consistent ‘narrative stream’ through the Qur'an. It is of some interest that both of these features have been singled out as distinctive of apocalypse as a genre in the study of numerous religious and cultural traditions. As debate on whether or not the Qur'an is a bona fide example of apocalyptic literature quietly continues, the interplay of conceptual and substantive oppositions and dualities is discussed in order to highlight the importance of this prominent feature to both the form and contents of the Book. It is suggested that its function is profoundly related to the typological figuration indispensable to the Qur'anic depiction of, for example, the character of the prophets and therefore prophethood. Whether or not this represents a genuine instance of apocalyptic literature, it nonetheless remains that the prominence of the motif renders the Qur'an susceptible of a reading expressive of something called an apocalyptic imagination. It is hoped that this article succeeds in demonstrating that in fact these apparently familiar subjects are stimulated to new life by considering them as defining, interlocking, structural elements of a distinctive Islamic apocalypse.

Multiculturalism

2018 ◽  
Author(s):  
Nasar Meer
Keyword(s):  
National Identity ◽  
Race Relations ◽  
National Identities ◽  
Policy Debate ◽  
Prominent Feature ◽  
Religious Minorities ◽  
The Core ◽  
National Question ◽  
Multicultural Citizenship ◽  
Future Status

The purpose of this chapter is to locate the discussion about Muslims in Scotland in relation to questions of national identity and multicultural citizenship. While the former has certainly been a prominent feature of public and policy debate, the latter has largely been overshadowed by constitutional questions raised by devolution and the referenda on independence. This means that, while we have undoubtedly progressed since MacEwen (1980) characterised the treatment of ‘race-relations’ in Scotland as a matter either of ‘ignorance or apathy’, the issue of where ethnic, racial and religious minorities rest in the contemporary landscape remains unsettled. One of the core arguments of this chapter is that these issues are all interrelated, and that the present and future status of Muslims in Scotland is tied up with wider debates about the ‘national question’. Hitherto, however, study of national identity in Scotland has often (though not always) been discussed in relation to the national identities of England, Wales and Britain as a whole.

Cracking national integration after the events (the Arab Spring) and its impact On regional stability

2019 ◽  
Vol 3 (6) ◽  
pp. 1
Author(s):  
Muhannad Al Janabi Al Janabi
Keyword(s):  
Arab Spring ◽  
The State ◽  
The Political ◽  
Prominent Feature ◽  
Regional Stability ◽  
National Integration ◽  
Arab Region ◽  
Political Media ◽  
The Stability ◽  
The Arab Spring

Since late 2010 and early 2011, the Arab region has witnessed mass protests in Tunisia, Egypt, Libya, Syria, Yemen, Iraq, Bahrain and other countries that have been referred to in the political, media and other literature as the Arab Spring. These movements have had a profound effect on the stability of the regimes Which took place against it, as leaders took off and contributed to radical reforms in party structures and public freedoms and the transfer of power, but it also contributed to the occurrence of many countries in an internal spiral, which led to the erosion of the state from the inside until it became a prominent feature of the Arab) as is the case in Syria, Libya, Yemen and Iraq.

Temps du deuil, temps du récit. Le renversement du temps dans La première année de Jean-Michel Espitallier

2020 ◽  
pp. 71-82
Author(s):  
Despina Jderu
Keyword(s):  
Narrative Structure ◽  
Literary Discourse ◽  
Prominent Feature ◽  
Literary Space ◽  
French Writer ◽  
Recent Activity ◽  
Nature Of Time ◽  
Denial Of Death ◽  
The Relationship

This paper aims to analyze the nature of time as identified in the narrative structure built by the French writer, Jean-Michel Espitallier, in his novel, La première année. We are considering how the author perceives the relationship between time and mourning through the ability of literary space to provide a compensatory universe. We are looking to observe recent activity in French mourning literature through the lens of this particularly novel, namely its perspective on processing mourning and trauma. This paper also highlights a prominent feature of French mourning literature: how the narrator’s literary discourse is used to fight against the passing of time. The fight against time is an implicit denial of death and mourning.

Aversive Textures and Their Role in Food Rejection

2020 ◽  
Author(s):  
Robert Pellegrino ◽  
Curtis Luckett
Keyword(s):  
Cluster Analysis ◽  
Psychological Factors ◽  
Sensory Attributes ◽  
Prominent Feature ◽  
Large Vocabulary ◽  
Common Food ◽  
Sensory Attribute ◽  
Touch Sensitivity

Texture is a prominent feature in foods and consequently can be the reason a food is accepted or rejected. However, other sensory attributes, such as flavor/taste, aroma, sound and appearance may also lead to the rejection of food and motivations other than unpleasantness exist in unacceptance. To date, these motivations for food rejection have been studied in isolation and their relationships with psychological factors have not been tested. This study measured reasons people reject a food and probed into the specifics of texture rejection. A large U.S. sample (N=473) was asked to rate their motivations for rejecting a food, list foods that were disliked due to unpleasant sensory attributes, specify the unpleasant sensory attribute(s), and complete an assessment of general touch sensitivity. Results showed 94% of individuals reject a food due to its texture, a rate comparable to flavor-based rejection. Looking at the number of foods being rejected, flavor was the most common food attribute, followed by texture and then aroma. From a linguistic standpoint, aversive textures encompass a large vocabulary, larger than liked textures, and the same food may be rejected due to a single or combination of texture terms. Viscosity (e.g. slimy) and hardness (e.g. mushy) are the most common aversive texture types, but through cluster analysis subsets of individuals were identified that are more aversive to other textures. This study emphasizes the role of aversive textures in food rejection and provides many avenues for future investigations.

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