scholarly journals DNase treatment prevents CSF block in early experimental pneumococcal meningitis

2021 ◽  
Author(s):  
Chiara Pavan ◽  
Anna LR Xavier ◽  
Marta Ramos ◽  
Jane Fisher ◽  
Marios Kritsilis ◽  
...  
Keyword(s):  
Pneumococcal Meningitis ◽  
Dnase Treatment ◽  
Experimental Pneumococcal Meningitis

Progression of Hearing Loss in Experimental Pneumococcal Meningitis: Correlation with Cerebrospinal Fluid Cytochemistry

1993 ◽  
Vol 167 (3) ◽  
pp. 675-683 ◽  
Author(s):  
S. M. Bhatt ◽  
A. Lauretano ◽  
C. Cabellos ◽  
C. Halpin ◽  
R. A. Levine ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Hearing Loss ◽  
Pneumococcal Meningitis ◽  
Experimental Pneumococcal Meningitis

Vitamin B6 prevents cognitive impairment in experimental pneumococcal meningitis

2014 ◽  
Vol 239 (10) ◽  
pp. 1360-1365 ◽  
Author(s):  
Tatiana Barichello ◽  
Jaqueline S Generoso ◽  
Lutiana R Simões ◽  
Renan A Ceretta ◽  
Diogo Dominguini ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Vitamin B6 ◽  
Pneumococcal Meningitis ◽  
Experimental Pneumococcal Meningitis

scholarly journals Inhibition of Leukocyte Entry into the Brain by the Selectin Blocker Fucoidin Decreases Interleukin-1 (IL-1) Levels but Increases IL-8 Levels in Cerebrospinal Fluid during Experimental Pneumococcal Meningitis in Rabbits

2000 ◽  
Vol 68 (6) ◽  
pp. 3153-3157 ◽  
Author(s):  
Christian Østergaard ◽  
Runa Vavia Yieng-Kow ◽  
Thomas Benfield ◽  
Niels Frimodt-Møller ◽  
Frank Espersen ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Pneumococcal Meningitis ◽  
Interleukin 1 ◽  
Treated Group ◽  
Control Group ◽  
Necrosis Factor Alpha ◽  
Tnf Α ◽  
Significant Difference ◽  
The Brain ◽  
Experimental Pneumococcal Meningitis

ABSTRACT The polysaccharide fucoidin is a selectin blocker that inhibits leukocyte recruitment into the cerebrospinal fluid (CSF) during experimental pneumococcal meningitis. In the present study, the effect of fucoidin treatment on the release of the proinflammatory cytokines tumor necrosis factor alpha (TNF-α), interleukin-1 (IL-1), and IL-8 into the CSF was investigated. Rabbits (n = 7) were treated intravenously with 10 mg of fucoidin/kg of body weight every second hour starting 4 h after intracisternal inoculation of ∼106 CFU of Streptococcus pneumoniae type 3 (untreated control group, n = 7). CSF samples were obtained every second hour during a 16-h study period. Treatment with fucoidin caused a consistent and significant decrease in CSF IL-1 levels (in picograms per milliliter) between 12 and 16 h (0 versus 170, 0 versus 526, and 60 versus 1,467, respectively;P < 0.02). A less consistent decrease in CSF TNF-α levels was observed in the fucoidin-treated group, but with no significant difference between the two groups (P > 0.05). In contrast, there was no attenuation in CSF IL-8 levels. Indeed, there was a significant increase in CSF IL-8 levels (in picograms per milliliter) in the fucoidin-treated group at 10 and 12 h (921 versus 574 and 1,397 versus 569, respectively;P < 0.09). In conclusion, our results suggest that blood-derived leukocytes mainly are responsible for the release of IL-1 and to some degree TNF-α into the CSF during pneumococcal meningitis, whereas IL-8 may be produced by local cells within the brain.

scholarly journals Prevention of Memory Impairment and Neurotrophic Factors Increased by Lithium in Wistar Rats Submitted to Pneumococcal Meningitis Model

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Lutiana R. Simões ◽  
Roberta R. E. S. Abreu ◽  
Jaqueline S. Generoso ◽  
Jéssica A. Goularte ◽  
Allan Collodel ◽  
...  
Keyword(s):  
Group Treatment ◽  
Neurotrophic Factor ◽  
Memory Impairment ◽  
Pneumococcal Meningitis ◽  
Mood Stabilizer ◽  
Inhibitory Avoidance ◽  
Saline Control ◽  
Artificial Cerebrospinal Fluid ◽  
The Brain ◽  
Experimental Pneumococcal Meningitis

The aim of this study was to investigate the effects of lithium on brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and glial cell line-derived neurotrophic factor (GDNF) expression in the hippocampus and on memory in experimental pneumococcal meningitis. The mood-stabilizer lithium is known as a neuroprotective agent with many effects on the brain. In this study, animals received either artificial cerebrospinal fluid or Streptococcus pneumoniae suspension at a concentration of 5 × 109 CFU/mL. Eighteen hours after induction, all animals received ceftriaxone. The animals received saline or lithium (47.5 mg/kg) or tamoxifen (1 mg/kg) as adjuvant treatment, and they were separated into six groups: control/saline, control/lithium, control/tamoxifen, meningitis/saline, meningitis/lithium, and meningitis/tamoxifen. Ten days after meningitis induction, animals were subjected to open-field habituation and the step-down inhibitory avoidance tasks. Immediately after these tasks, the animals were killed and their hippocampus was removed to evaluate the expression of BDNF, NGF, and GDNF. In the meningitis group, treatment with lithium and tamoxifen resulted in improvement in memory. Meningitis group showed decreased expression of BDNF and GDNF in the hippocampus while lithium reestablished the neurotrophin expression. Lithium was able to prevent memory impairment and reestablishes hippocampal neurotrophin expression in experimental pneumococcal meningitis.

Cefamandole in the therapy of experimental pneumococcal meningitis

1976 ◽  
Vol 2 (2) ◽  
pp. 159-165 ◽  
Author(s):  
Robert J. Sherertz ◽  
Ralph Dacey ◽  
Merle A. Sande
Keyword(s):  
Pneumococcal Meningitis ◽  
Experimental Pneumococcal Meningitis
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