Effects of IgLON5 Antibodies on Neuronal Cytoskeleton: A Link between Autoimmunity and Neurodegeneration

2020 ◽  
Vol 88 (5) ◽  
pp. 1023-1027 ◽  
Author(s):  
Jon Landa ◽  
Carles Gaig ◽  
Jesús Plagumà ◽  
Albert Saiz ◽  
Ana Antonell ◽  
...  
Keyword(s):  
Neuronal Cytoskeleton

Alzheimer's Paired Helical Filaments Contain Insoluble Cytoskeletal Elements

1985 ◽  
Vol 43 ◽  
pp. 748-751
Author(s):  
P. Gambetti ◽  
G. Perry ◽  
L. Autillo-Gambetti
Keyword(s):  
Paired Helical Filaments ◽  
Microscope Level ◽  
Antigenic Determinants ◽  
Light Microscope Level ◽  
Neuronal Cytoskeleton ◽  
Ionic Detergent ◽  
Associated Proteins ◽  
Pathologic Lesions ◽  
10 Nm Filaments ◽  
Cytoskeletal Elements

Neurofibrillary tangles (NFT) are one of the major pathologic lesions of Alzheimer's disease. These neuronal inclusions are predominantly composed of paired helical filaments (PHF), which consist of two 10 nm filaments winding around each other with an approximately 80 nm periodicity. Besides PHF, NFT comprise also 15 nm filaments, 10 nm filaments which are probably neurofilaments, microtubules and granular material. At variance with the neuronal cytoskeleton, PHF are insoluble in ionic detergent.Studies at the light microscope level have shown that NFT have unique antigenic determinants as well as determinants in common with elements of the normal neuronal cytoskeleton such as neurofilaments and microtubule-associated proteins. The present study uses immunocytochemistry and cytochemistry at the electron microscope level to assess which NFT component contains these determinants and whether these antigenic determinants are soluble in an ionic detergent.

scholarly journals Progressive and spatially differentiated stability of microtubules in developing neuronal cells.

1989 ◽  
Vol 109 (1) ◽  
pp. 253-263 ◽  
Author(s):  
S S Lim ◽  
P J Sammak ◽  
G G Borisy
Keyword(s):  
Cell Body ◽  
Growth Cone ◽  
Cellular Differentiation ◽  
Progressive Increase ◽  
Fluorescence Recovery ◽  
Plastic Properties ◽  
Intracellular Location ◽  
Laser Microbeam ◽  
Neuronal Cytoskeleton ◽  
The Stability

The establishment of neural circuits requires both stable and plastic properties in the neuronal cytoskeleton. In this study we show that properties of stability and lability reside in microtubules and these are governed by cellular differentiation and intracellular location. After culture for 3, 7, and 14 d in nerve growth factor-containing medium, PC-12 cells were microinjected with X-rhodamine-labeled tubulin. 8-24 h later, cells were photobleached with a laser microbeam at the cell body, neurite shaft, and growth cone. Replacement of fluorescence in bleached zones was monitored by digital video microscopy. In 3-d cultures, fluorescence recovery in all regions occurred by 26 +/- 17 min. Similarly, in older cultures, complete fluorescence recovery at the cell body and growth cone occurred by 10-30 min. However, in neurite shafts, fluorescence recovery was markedly slower (71 +/- 48 min for 7-d and 201 +/- 94 min for 14-d cultures). This progressive increase in the stability of microtubules in the neurite shafts correlated with an increase of acetylated microtubules. Acetylated microtubules were present specifically in the neurite shaft and not in the regions of fast microtubule turnover, the cell body and growth cone. During the recovery of fluorescence, bleached zones did not move with respect to the cell body. We conclude that the microtubule component of the neuronal cytoskeleton is differentially dynamic but stationary.

The Aging of the Neuronal Cytoskeleton

2017 ◽  
pp. 327-352
Author(s):  
P. Klosen ◽  
Ph. van den Bosch de Aguilar
Keyword(s):  
Neuronal Cytoskeleton

Translocation of the neuronal cytoskeleton and axonal locomotion

1982 ◽  
Vol 299 (1095) ◽  
pp. 313-327 ◽  
Keyword(s):  
Plasma Membrane ◽  
Axonal Transport ◽  
Cell Body ◽  
Cytoskeletal Proteins ◽  
The Other ◽  
Current Understanding ◽  
Axonal Elongation ◽  
Neuronal Cytoskeleton ◽  
Other Hand ◽  
Neuron Cell Body

Recent studies of axonal transport indicate that cytoskeletal proteins are assembled into polymers in the neuron cell body and that these polymers move from the cell body toward the end of the axon. On the other hand, membranous elements appear to be inserted into the axonal plasma membrane preferentially at the end of the axon. These new observations are explored in relation to our current understanding of axonal elongation.

The Neuronal Cytoskeleton and Neurofibrillary Tangles

1986 ◽  
pp. 35-52
Author(s):  
B. H. Anderton ◽  
J.-P. Brion ◽  
J. Flament-Durand ◽  
M. C. Haugh ◽  
J. Kahn ◽  
...  
Keyword(s):  
Neurofibrillary Tangles ◽  
Neuronal Cytoskeleton
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