Haploinsufficiency of Cyfip2 Causes Lithium‐Responsive Prefrontal Dysfunction

2020 ◽  
Vol 88 (3) ◽  
pp. 526-543 ◽  
Author(s):  
Seung‐Hyun Lee ◽  
Yinhua Zhang ◽  
Jina Park ◽  
Bowon Kim ◽  
Yangsik Kim ◽  
...  
Keyword(s):  
Prefrontal Dysfunction

Progressive Frontal Dysconnectivity During Working Memory in eos Patients: A Longitudinal Functional MRI Study

2017 ◽  
Vol 41 (S1) ◽  
pp. S60-S60
Author(s):  
S. Frangou ◽  
M. Kyriakopoulos ◽  
D. Danai
Keyword(s):  
Working Memory ◽  
Functional Connectivity ◽  
Disease Onset ◽  
Blood Oxygenation ◽  
Typically Developing ◽  
Prefrontal Dysfunction ◽  
Oxygenation Level ◽  
Dependent Signal ◽  
Competing Interest ◽  
Mri Study

Working memory (WM) dysfunction is considered a cardinal feature of schizophrenia. Typically developing adolescents show significant gains in WM performance, which have been attributed to increased “frontalisation” within the fronto-cingulate-parietal network that underpins WM. We used functional magnetic resonance imaging and psycho-physiological interaction to measure blood oxygenation level–dependent signal and functional connectivity in response to the 2-back WM task from 25 youths with EOS and 25 yoked healthy adolescents that were assessed twice with a mean interval of 4 years between assessments. Patients showed reduced prefrontal connectivity at baseline and the magnitude of this effect increased over the follow-up period. Our results suggest on-going functional connectivity abnormalities in EOS patients’ post-disease onset that are linked to prefrontal dysfunction and contribute to worsening WM despite anti–psychotic treatment.Disclosure of interestThe authors have not supplied their declaration of competing interest.

A review of transcranial magnetic stimulation for treating negative symptoms of schizophrenia

2016 ◽  
Vol 33 (S1) ◽  
pp. S554-S555
Author(s):  
J. Oliveira ◽  
G. Sobreira ◽  
C.A. Moreira ◽  
M.A. Aleixo ◽  
S. Brissos
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Magnetic Stimulation ◽  
Negative Symptoms ◽  
Current Evidence ◽  
Positive Effects ◽  
Prefrontal Function ◽  
Prefrontal Dysfunction ◽  
Pubmed Database ◽  
Dorsolateral Prefrontal ◽  
Competing Interest

IntroductionThe finding of prefrontal dysfunction in schizophrenia patients with negative symptoms (NS) has raised interest in using transcranial magnetic stimulation (TMS), which can modulate prefrontal function and dopamine release, as potential treatment for NS.ObjectiveTo briefly review current literature concerning the use of TMS as treatment for NS.AimsTo assess whether current evidence supports the use of TMS for NS.MethodsNarrative review of articles found through a PubMed database search using the keywords “transcranial magnetic stimulation”, “schizophrenia”, and “negative symptoms” between 1998 and 2015.ResultsUp to date, reviews of randomized sham-controlled studies found positive effects of TMS in NS. However, they exposed several methodological difficulties. More recent studies, reviewed in this poster, tried to overcome these, using results from multiple centers, larger samples and blinding. Various TMS techniques were studied, differing in frequency, motor threshold (MT), stimulus location, and treatment duration. Overall, TMS continues to show promising results in reducing NS; particularly rTMS 10 Hz, for at least 15 sessions on the left dorsolateral prefrontal cortex (DLPFC) at a 110% MT.ConclusionsTMS may be a useful treatment for NS for patients not responding to pharmacological treatment alone. Studies remain difficult to compare due to different measures of outcome (PANSS and SANS being the most commonly used) and techniques. Furthermore, possible modulators of response include duration of illness, cognitive symptoms amelioration, medication and their dose, and different NS may respond differently to TMS. More studies are needed to better understand the utility of TMS in NS.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Age-related working memory impairments in children with prefrontal dysfunction associated with phenylketonuria

2002 ◽  
Vol 8 (1) ◽  
pp. 1-11 ◽  
Author(s):  
DESIR??E A. WHITE ◽  
MARSHA J. NORTZ ◽  
TAMMY MANDERNACH ◽  
KATHLEEN HUNTINGTON ◽  
ROBERT D. STEINER
Keyword(s):  
Working Memory ◽  
Memory Impairments ◽  
Prefrontal Dysfunction ◽  
Age Related

Prefrontal Dysfunction in Early and Continuously Treated Phenylketonuria

1999 ◽  
Vol 16 (1) ◽  
pp. 29-57 ◽  
Author(s):  
Nanke B. A. Stemerdink ◽  
Maurits W. van der Molen ◽  
Alex F. Kalverboer ◽  
Jaap J. van der Meere ◽  
Jaap Huisman ◽  
...  
Keyword(s):  
Prefrontal Dysfunction

Deficits in memory strategy use related to prefrontal dysfunction during early development: Evidence from children with phenylketonuria.

2001 ◽  
Vol 15 (2) ◽  
pp. 221-229 ◽  
Author(s):  
Desirée A. White ◽  
Marsha J. Nortz ◽  
Tammy Mandernach ◽  
Kathleen Huntington ◽  
Robert D. Steiner
Keyword(s):  
Early Development ◽  
Strategy Use ◽  
Memory Strategy ◽  
Prefrontal Dysfunction

An fMRI study of prefrontal dysfunction and symptomatic recovery in schizophrenia

2010 ◽  
Vol 123 (6) ◽  
pp. 440-450 ◽  
Author(s):  
C. Smee ◽  
L. Krabbendam ◽  
O. O’Daly ◽  
A.-M. Prins ◽  
N. Nalesnik ◽  
...  
Keyword(s):  
Prefrontal Dysfunction ◽  
Fmri Study

Measures of Prefrontal Dysfunction after Closed Head Injury

1996 ◽  
Vol 30 (2) ◽  
pp. 194-204 ◽  
Author(s):  
David A. Gansler ◽  
Stephanie Covall ◽  
Neal McGrath ◽  
Marlene Oscar-Berman
Keyword(s):  
Head Injury ◽  
Closed Head Injury ◽  
Prefrontal Dysfunction ◽  
Closed Head
Sign in / Sign up

Export Citation Format

Share Document