The CSF Profile Linked to Cortical Damage Predicts Multiple Sclerosis Activity

2020 ◽  
Vol 88 (3) ◽  
pp. 562-573 ◽  
Author(s):  
Roberta Magliozzi ◽  
Antonio Scalfari ◽  
Anna Isabella Pisani ◽  
Stefano Ziccardi ◽  
Damiano Marastoni ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cortical Damage

scholarly journals MR spectroscopic evidence for thalamic and hippocampal, but not cortical, damage in multiple sclerosis

2006 ◽  
Vol 55 (3) ◽  
pp. 478-483 ◽  
Author(s):  
Jeroen J. G. Geurts ◽  
Ilona E. W. Reuling ◽  
Hugo Vrenken ◽  
Bernard M. J. Uitdehaag ◽  
Chris H. Polman ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Spectroscopic Evidence ◽  
Cortical Damage

Longitudinal quantitative MRI assessment of cortical damage in multiple sclerosis: A pilot study

2017 ◽  
Vol 46 (5) ◽  
pp. 1485-1490 ◽  
Author(s):  
René-Maxime Gracien ◽  
Sarah C. Reitz ◽  
Stephanie-Michelle Hof ◽  
Vinzenz Fleischer ◽  
Amgad Droby ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Pilot Study ◽  
Quantitative Mri ◽  
Cortical Damage

Cortical Damage and Disability in Multiple Sclerosis: Relation to Intracortical Inhibition and Facilitation

2016 ◽  
Vol 9 (4) ◽  
pp. 566-573 ◽  
Author(s):  
Julia C. Nantes ◽  
Jidan Zhong ◽  
Scott A. Holmes ◽  
Sridar Narayanan ◽  
Yves Lapierre ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Intracortical Inhibition ◽  
Cortical Damage ◽  
Intracortical Inhibition And Facilitation

scholarly journals Environmental enrichment improves cognitive symptoms and pathological features in a focal model of cortical damage of multiple sclerosis

2020 ◽  
Vol 1727 ◽  
pp. 146520 ◽  
Author(s):  
Berenice Anabel Silva ◽  
María Celeste Leal ◽  
María Isabel Farías ◽  
Brenda Erhardt ◽  
Pablo Galeano ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Environmental Enrichment ◽  
Cognitive Symptoms ◽  
Pathological Features ◽  
Cortical Damage

Quantification of cortical damage in multiple sclerosis using DTI remains a challenge

Brain ◽  
2019 ◽  
Vol 142 (7) ◽  
pp. 1848-1850
Author(s):  
Stefan Ropele ◽  
Franz Fazekas
Keyword(s):  
Multiple Sclerosis ◽  
Cortical Damage

Multimodal quantitative MRI assessment of cortical damage in relapsing-remitting multiple sclerosis

2016 ◽  
Vol 44 (6) ◽  
pp. 1600-1607 ◽  
Author(s):  
René-Maxime Gracien ◽  
Alina Jurcoane ◽  
Marlies Wagner ◽  
Sarah C. Reitz ◽  
Christoph Mayer ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Quantitative Mri ◽  
Cortical Damage ◽  
Relapsing Remitting ◽  
Remitting Multiple Sclerosis ◽  
Relapsing Remitting Multiple Sclerosis

The cortical damage, early relapses, and onset of the progressive phase in multiple sclerosis

Neurology ◽  
2018 ◽  
Vol 90 (24) ◽  
pp. e2107-e2118 ◽  
Author(s):  
Antonio Scalfari ◽  
Chiara Romualdi ◽  
Richard S. Nicholas ◽  
Miriam Mattoscio ◽  
Roberta Magliozzi ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cox Regression ◽  
Age At Onset ◽  
Cortical Atrophy ◽  
Clinical Activity ◽  
Cortical Damage ◽  
Clinical Onset ◽  
Kaplan Meier ◽  
Relapsing Remitting ◽  
Risk Of Progression

ObjectiveTo investigate the relationship among cortical radiologic changes, the number of early relapses (ERs), and the long-term course of multiple sclerosis (MS).MethodsIn this cohort study, we assessed the number of cortical lesions (CLs) and white matter (WM) lesions and the cortical thickness (Cth) at clinical onset and after 7.9 mean years among 219 patients with relapsing remitting (RR) MS with 1 (Low-ER), 2 (Mid-ER), and ≥3 (High-ER) ERs during the first 2 years. Kaplan-Meier and Cox regression analyses investigated early factors influencing the risk of secondary progressive (SP) MS.ResultsFifty-nine patients (27%) converted to SPMS in 6.1 mean years. A larger number of CLs at onset predicted a higher risk of SPMS (hazard ratio [HR] 2.16, 4.79, and 12.3 for 2, 5, and 7 CLs, respectively, p < 0.001) and shorter latency to progression. The High-ER compared to the Low-ER and Mid-ER groups had a larger volume of WM lesions and CLs at onset, accrued more CLs, experienced more severe cortical atrophy over time, and entered the SP phase more rapidly. In the multivariate model, older age at onset (HR 1.97, p < 0.001), a larger baseline CL (HR 2.21, p = 0.005) and WM lesion (HR 1.32, p = 0.03) volume, early changes of global Cth (HR 1.36, p = 0.03), and ≥3 ERs (HR 6.08, p < 0.001) independently predicted a higher probability of SP.ConclusionsExtensive cortical damage at onset is associated with florid inflammatory clinical activity and predisposes to a rapid occurrence of the progressive phase. Age at onset, the number of early attacks, and the extent of baseline focal cortical damage can identify groups at high risk of progression who may benefit from more active therapy.

scholarly journals Imaging Cortical Damage and Dysfunction in Multiple Sclerosis

2013 ◽  
Vol 70 (5) ◽  
pp. 556 ◽  
Author(s):  
Massimo Filippi ◽  
Maria A. Rocca ◽  
Mark A. Horsfield ◽  
Simon Hametner ◽  
Jeroen J. G. Geurts ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cortical Damage

scholarly journals Laminar cortical damage in multiple sclerosis

Brain ◽  
2015 ◽  
Vol 138 (4) ◽  
pp. 828-829 ◽  
Author(s):  
Frederik Barkhof ◽  
Jeroen J. G. Geurts
Keyword(s):  
Multiple Sclerosis ◽  
Cortical Damage
Sign in / Sign up

Export Citation Format

Share Document