scholarly journals Reduction of skin innervation is associated with a severe fibromyalgia phenotype

2019 ◽  
Vol 86 (4) ◽  
pp. 504-516 ◽  
Author(s):  
Dimitar Evdokimov ◽  
Johanna Frank ◽  
Alexander Klitsch ◽  
Stefan Unterecker ◽  
Bodo Warrings ◽  
...  
Keyword(s):  
Skin Innervation

Sensory profiles and skin innervation of patients with painful and painless neuropathies

Pain ◽  
2018 ◽  
pp. 1 ◽  
Author(s):  
Nurcan Üçeyler ◽  
Jan Vollert ◽  
Barbara Broll ◽  
Nadja Riediger ◽  
Melissa Langjahr ◽  
...  
Keyword(s):  
Skin Innervation ◽  
Sensory Profiles

Developmental timing of hair follicle and dorsal skin innervation in mice

2002 ◽  
Vol 448 (1) ◽  
pp. 28-52 ◽  
Author(s):  
Eva M.J. Peters ◽  
Vladimir A. Botchkarev ◽  
Sven Müller-Röver ◽  
Ingrid Moll ◽  
Frank L. Rice ◽  
...  
Keyword(s):  
Hair Follicle ◽  
Developmental Timing ◽  
Dorsal Skin ◽  
Skin Innervation

scholarly journals Hair Cycle-Dependent Changes in Adrenergic Skin Innervation, and Hair Growth Modulation by Adrenergic Drugs

1999 ◽  
Vol 113 (6) ◽  
pp. 878-887 ◽  
Author(s):  
Vladimir A. Botchkarev ◽  
Eva M.J. Peters ◽  
Natalia V. Botchkareva ◽  
Marcus Maurer ◽  
Ralf Paus
Keyword(s):  
Hair Growth ◽  
Hair Cycle ◽  
Growth Modulation ◽  
Skin Innervation ◽  
Adrenergic Drugs ◽  
Cycle Dependent

scholarly journals Prokineticin 2 Upregulation in the Peripheral Nervous System Has a Major Role in Triggering and Maintaining Neuropathic Pain in the Chronic Constriction Injury Model

2015 ◽  
Vol 2015 ◽  
pp. 1-15 ◽  
Author(s):  
Roberta Lattanzi ◽  
Daniela Maftei ◽  
Veronica Marconi ◽  
Fulvio Florenzano ◽  
Silvia Franchi ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Chronic Constriction Injury ◽  
Axon Degeneration ◽  
Protein Overexpression ◽  
Post Injury ◽  
Skin Innervation ◽  
Prokineticin 2 ◽  
Injury Model ◽  
Novel Target ◽  
Chronic Constriction Injury Model

The new chemokine Prokineticin 2 (PROK2) and its receptors (PKR1and PKR2) have a role in inflammatory pain and immunomodulation. Here we identified PROK2 as a critical mediator of neuropathic pain in the chronic constriction injury (CCI) of the sciatic nerve in mice and demonstrated that blocking the prokineticin receptors with two PKR1-preferring antagonists (PC1 and PC7) reduces pain and nerve damage. PROK2 mRNA expression was upregulated in the injured nerve since day 3 post injury (dpi) and in the ipsilateral DRG since 6 dpi. PROK2 protein overexpression was evident in Schwann Cells, infiltrating macrophages and axons in the peripheral nerve and in the neuronal bodies and some satellite cells in the DRG. Therapeutic treatment of neuropathic mice with the PKR-antagonist, PC1, impaired the PROK2 upregulation and signalling. This fact, besides alleviating pain, brought down the burden of proinflammatory cytokines in the damaged nerve and prompted an anti-inflammatory repair program. Such a treatment also reduced intraneural oedema and axon degeneration as demonstrated by the physiological skin innervation and thickness conserved in CCI-PC1 mice. These findings suggest that PROK2 plays a crucial role in neuropathic pain and might represent a novel target of treatment for this disease.

No change in skin innervation in patients with palmar hyperhidrosis treated with tap-water iontophoresis

1994 ◽  
Vol 131 (5) ◽  
pp. 742-743 ◽  
Author(s):  
L. Wang ◽  
M. Hilliges ◽  
M. Gajecki ◽  
J. A. Marcusson ◽  
O. Johansson
Keyword(s):  
Tap Water ◽  
Palmar Hyperhidrosis ◽  
Skin Innervation

scholarly journals Effect of Experimental Gestational Diabetes Mellitus on Mechanical Sensitivity, Capsaicin-Induced Pain Behaviors and Hind Paw Glabrous Skin Innervation of Male and Female Mouse Offspring

2021 ◽  
Vol Volume 14 ◽  
pp. 1573-1585
Author(s):  
Enriqueta Munoz-Islas ◽  
Cecilia Esther Elizondo-Martinez ◽  
Mariela Gutierrez-Lopez ◽  
Rosa Issel Acosta-Gonzalez ◽  
Veronica Zaga-Clavellina ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Female Mouse ◽  
Glabrous Skin ◽  
Mechanical Sensitivity ◽  
Male And Female ◽  
Pain Behaviors ◽  
Skin Innervation

scholarly journals Treatment of Diabetic Neuropathy with A Novel PAR1-Targeting Molecule

Biomolecules ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 1552
Author(s):  
Efrat Shavit-Stein ◽  
Shany Guly Gofrit ◽  
Alexandra Gayster ◽  
Yotam Teldan ◽  
Ariel Ron ◽  
...  
Keyword(s):  
Conduction Velocity ◽  
Nerve Conduction Velocity ◽  
Coagulation Factor ◽  
Streptozotocin Diabetes ◽  
Sensory Function ◽  
Glucose Levels ◽  
Skin Innervation ◽  
Diabetes Model ◽  
Protease Activated Receptor 1 ◽  
G Protein Coupled

Diabetic peripheral neuropathy (DPN) is a disabling common complication of diabetes mellitus (DM). Thrombin, a coagulation factor, is increased in DM and affects nerve function via its G-protein coupled protease activated receptor 1 (PAR1). Methods: A novel PAR1 modulator (PARIN5) was designed based on the thrombin PAR1 recognition site. Coagulation, motor and sensory function and small fiber loss were evaluated by employing the murine streptozotocin diabetes model. Results: PARIN5 showed a safe coagulation profile and showed no significant effect on weight or glucose levels. Diabetic mice spent shorter time on the rotarod (p < 0.001), and had hypoalgesia (p < 0.05), slow conduction velocity (p < 0.0001) and reduced skin innervation (p < 0.0001). Treatment with PARIN5 significantly improved rotarod performance (p < 0.05), normalized hypoalgesia (p < 0.05), attenuated slowing of nerve conduction velocity (p < 0.05) and improved skin innervation (p <0.0001). Conclusion: PARIN5 is a novel pharmacological approach for prevention of DPN development, via PAR1 pathway modulation.

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