Functional magnetic resonance imaging of human motor unit fasciculation in amyotrophic lateral sclerosis

2019 ◽  
Author(s):  
Roger G. Whittaker ◽  
Paola Porcari ◽  
Luis Braz ◽  
Timothy L. Williams ◽  
Ian S. Schofield ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Amyotrophic Lateral Sclerosis ◽  
Magnetic Resonance ◽  
Functional Magnetic Resonance Imaging ◽  
Motor Unit ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging ◽  
Human Motor ◽  
Lateral Sclerosis

scholarly journals Integration of structural and functional magnetic resonance imaging in amyotrophic lateral sclerosis

Brain ◽  
2011 ◽  
Vol 134 (12) ◽  
pp. 3470-3479 ◽  
Author(s):  
Gwenaëlle Douaud ◽  
Nicola Filippini ◽  
Steven Knight ◽  
Kevin Talbot ◽  
Martin R. Turner
Keyword(s):  
Magnetic Resonance Imaging ◽  
Amyotrophic Lateral Sclerosis ◽  
Magnetic Resonance ◽  
Functional Magnetic Resonance Imaging ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging ◽  
Lateral Sclerosis

scholarly journals Functional Magnetic Resonance Imaging of the Human Motor Cortex

1995 ◽  
Vol 35 (5) ◽  
pp. 277-284 ◽  
Author(s):  
Masahiro SASAHIRA ◽  
Tetsuhiko ASAKURA ◽  
Masaki NIIRO ◽  
Akihiro HARUZONO ◽  
Wataru HIRAKAWA ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Motor Cortex ◽  
Functional Magnetic Resonance Imaging ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging ◽  
Human Motor Cortex ◽  
Human Motor

scholarly journals Ultra-high field (7T) functional magnetic resonance imaging in amyotrophic lateral sclerosis

2020 ◽  
Author(s):  
Robert L. Barry ◽  
Suma Babu ◽  
Sheeba Arnold Anteraper ◽  
Christina Triantafyllou ◽  
Boris Keil ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Amyotrophic Lateral Sclerosis ◽  
Magnetic Resonance ◽  
High Resolution ◽  
Functional Connectivity ◽  
High Field ◽  
Functional Magnetic Resonance ◽  
Resonance Imaging ◽  
Ultra High Field ◽  
Lateral Sclerosis

AbstractAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of the central nervous system that results in a progressive loss of motor function and ultimately death. It is crit-ical, yet also challenging, to develop non-invasive biomarkers to identify, localize, measure and/or track biological mechanisms implicated in ALS. Such biomarkers may also provide clues to identify potential molecular targets for future therapeutic trials. Herein we report on twelve participants with ALS and nine age-matched healthy controls who underwent high-resolution resting state functional magnetic resonance imaging at an ultra-high field of 7 Tesla. Group-level whole-brain analyses revealed a disruption in long-range functional connectivity between the superior sensorimotor cortex (in the precentral gyrus) and bi-lateral cerebellar lobule VI. Post hoc analyses using atlas-derived left and right cerebellar lobule VI revealed decreased functional connectivity in ALS participants that predomi-nantly map to bilateral postcentral and precentral gyri. Cerebellar lobule VI is a transition zone between anterior motor networks and posterior non-motor networks in the cerebellum, and has been associated with a wide range of key functions including complex motor and cognitive processing tasks. Our observation of the involvement of cerebellar lobule VI adds to the growing number of studies implicating the cerebellum in ALS. Future avenues of scientific investigation should consider how high-resolution imaging at 7T may be leveraged to visualize differences in functional connectivity disturbances in various genotypes and phenotypes of ALS along the ALS-frontotemporal dementia spectrum.

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