Diabetic neuropathy differs between type 1 and type 2 diabetes: Insights from magnetic resonance neurography

2018 ◽  
Vol 83 (3) ◽  
pp. 588-598 ◽  
Author(s):  
Johann M. E. Jende ◽  
Jan B. Groener ◽  
Dimitrios Oikonomou ◽  
Sabine Heiland ◽  
Stefan Kopf ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Magnetic Resonance ◽  
Diabetic Neuropathy ◽  
Magnetic Resonance Neurography

scholarly journals Troponin T Parallels Structural Nerve Damage in Type 2 Diabetes: A Cross-sectional Study Using Magnetic Resonance Neurography

Diabetes ◽  
2020 ◽  
Vol 69 (4) ◽  
pp. 713-723 ◽  
Author(s):  
Johann M.E. Jende ◽  
Jan B. Groener ◽  
Zoltan Kender ◽  
Artur Hahn ◽  
Jakob Morgenstern ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Magnetic Resonance ◽  
Troponin T ◽  
Cross Sectional Study ◽  
Nerve Damage ◽  
Sectional Study ◽  
Magnetic Resonance Neurography ◽  
Cross Sectional

Painful and non-painful diabetic neuropathy, diagnostic challenges and implications for future management

Brain ◽  
2021 ◽  
Author(s):  
Troels S Jensen ◽  
Pall Karlsson ◽  
Sandra S Gylfadottir ◽  
Signe T Andersen ◽  
David L Bennett ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Clinical Trials ◽  
Diabetic Neuropathy ◽  
Randomized Clinical Trials ◽  
Early Recognition ◽  
Sensory Profile ◽  
Research Perspectives ◽  
Distal Symmetric Polyneuropathy

Abstract Peripheral neuropathy is one of the most common complications of both type 1 and type 2 diabetes. Up to half of patients with diabetes develop neuropathy during the course of their disease, which is accompanied by neuropathic pain in to 30–40% of cases. Peripheral nerve injury in diabetes can manifest as progressive distal symmetric polyneuropathy, autonomic neuropathy, radiculo-plexopathies, and mononeuropathies. The most common diabetic neuropathy is distal symmetric polyneuropathy, which we will refer to as DN, with its characteristic glove and stocking like presentation of distal sensory or motor function loss. DN or its painful counterpart, painful DN, are associated with increased mortality and morbidity; thus, early recognition and preventive measures are essential. Nevertheless, it is not easy to diagnose DN or painful DN, particularly in patients with early and mild neuropathy, and there is currently no single established diagnostic gold standard. The most common diagnostic approach in research is a hierarchical system, which combines symptoms, signs, and a series of confirmatory tests. The general lack of long-term prospective studies has limited the evaluation of the sensitivity and specificity of new morphometric and neurophysiological techniques. Thus, the best paradigm for screening DN and painful DN both in research and in clinical practice remains uncertain. Herein, we review the diagnostic challenges from both clinical and research perspectives and their implications for managing patients with DN. There is no established DN treatment, apart from improved glycemic control, which is more effective in type 1 than in type 2 diabetes, and only symptomatic management is available for painful DN. Currently, less than one third of painful DN patients derive sufficient pain relief with existing pharmacotherapies. A more precise and distinct sensory profile from patients with DN and painful DN may help identify responsive patients to one treatment versus another. Detailed sensory profiles will lead to tailored treatment for patient subgroups with painful DN by matching to novel or established DN pathomechanisms and also for improved clinical trials stratification. Large randomized clinical trials are needed to identify the interventions, i.e. pharmacological, physical, cognitive, educational, etc, which leads to the best therapeutic outcomes.

Characteristics of gastric emptying and diabetic neuropathy in patients with short-standing Type-1 and Type-2 diabetes

2009 ◽  
Vol 47 (05) ◽  
Author(s):  
T Várkonyi ◽  
É Börcsök ◽  
R Takács ◽  
V Szidor ◽  
A Szász ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Gastric Emptying ◽  
Diabetic Neuropathy

scholarly journals The Relationship between Diabetic Neuropathy and Sleep Apnea Syndrome: A Meta-Analysis

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Kazuya Fujihara ◽  
Satoru Kodama ◽  
Chika Horikawa ◽  
Sakiko Yoshizawa ◽  
Ayumi Sugawara ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Type 1 Diabetes ◽  
Sleep Apnea ◽  
Diabetic Neuropathy ◽  
Meta Analysis ◽  
Sleep Apnea Syndrome ◽  
High Prevalence ◽  
Apnea Syndrome

Aims. High prevalence of sleep apnea syndrome (SAS) has been reported in patients with diabetes. However, whether diabetic neuropathy (DN) contributes to this high prevalence is controversial. Our aim of this study is to compare the prevalence of SAS between patients with and without DN.Methods. Systematic literature searches were conducted for cross-sectional studies that reported the number of patients with DN and SAS using MEDLINE (from 1966 to Nov 5, 2012) and EMBASE (from 1974 to Nov 5, 2012). Odds ratios (ORs) of SAS related to DN were pooled with the Mantel-Haenszel method.Results. Data were obtained from 5 eligible studies (including 6 data sets, 880 participants, and 429 cases). Overall, the pooled OR of SAS in patients with DN compared with that in non-DN patients was significant (OR (95% CI), −1.95 (1.03–3.70)). The pooled OR of SAS was 1.90 (0.97–3.71) in patients with type 2 diabetes. Excluding data on patients with type 1 diabetes, a higher OR was observed in younger patients (mean age <60 years) than in those ≥60 years among whom the OR remained significant (3.82; 95% CI, 2.24–6.51 and 1.17; 95% CI, 0.81–1.68).Conclusions. Current meta-analysis suggested the association of some elements of neuropathy with SAS in type 2 diabetes. Further investigations are needed to clarify whether the association is also true for patients with type 1 diabetes.

Diabetic neuropathy in patients with "Latent Autoimmune Diabetes of the Adults" (LADA) compared with patients with type 1 and type 2 diabetes

2003 ◽  
Vol 250 (6) ◽  
pp. 682-687 ◽  
Author(s):  
Petra Baum ◽  
Wieland Hermann ◽  
Hans-Jochen Verlohren ◽  
Armin Wagner ◽  
Tobias Lohmann ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Neuropathy ◽  
Autoimmune Diabetes ◽  
Latent Autoimmune Diabetes
Sign in / Sign up

Export Citation Format

Share Document