scholarly journals Deep gray matter volume loss drives disability worsening in multiple sclerosis

2018 ◽  
Vol 83 (2) ◽  
pp. 210-222 ◽  
Author(s):  
Arman Eshaghi ◽  
Ferran Prados ◽  
Wallace J. Brownlee ◽  
Daniel R. Altmann ◽  
Carmen Tur ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Volume Loss ◽  
Matter Volume ◽  
Deep Gray Matter

The Impact of MRI T1 Hypointense Brain Lesions on Cerebral Deep Gray Matter Volume Measures in Multiple Sclerosis

2019 ◽  
Author(s):  
Korhan Buyukturkoglu ◽  
Enricomaria Mormina ◽  
Philip L. Jager ◽  
Claire S. Riley ◽  
Victoria M. Leavitt
Keyword(s):  
Multiple Sclerosis ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Brain Lesions ◽  
Matter Volume ◽  
Deep Gray Matter ◽  
The Impact

Association of regional gray matter volume loss and progression of white matter lesions in multiple sclerosis — A longitudinal voxel-based morphometry study

NeuroImage ◽  
2009 ◽  
Vol 45 (1) ◽  
pp. 60-67 ◽  
Author(s):  
Kerstin Bendfeldt ◽  
Pascal Kuster ◽  
Stefan Traud ◽  
Hanspeter Egger ◽  
Sebastian Winklhofer ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
White Matter Lesions ◽  
Volume Loss ◽  
Voxel Based Morphometry ◽  
Matter Volume

Association of Age at Onset With Gray Matter Volume and White Matter Microstructural Abnormalities in People With Multiple Sclerosis

Neurology ◽  
2021 ◽  
pp. 10.1212/WNL.0000000000012869
Author(s):  
Raffaello Bonacchi ◽  
Alessandro Meani ◽  
Elisabetta Pagani ◽  
Olga Marchesi ◽  
Andrea Falini ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
White Matter ◽  
Gray Matter ◽  
Linear Models ◽  
Gray Matter Volume ◽  
Age At Onset ◽  
Healthy Controls ◽  
Compensatory Mechanisms ◽  
Cross Sectional ◽  
Matter Volume

Objective:To investigate whether age at onset influences brain gray matter volume (GMV) and white matter (WM) microstructural abnormalities in adult multiple sclerosis (MS) patients, given its influence on clinical phenotype and disease course.Method:In this hypothesis-driven cross-sectional study, we enrolled 67 pediatric-onset MS (POMS) patients and 143 sex- and disease duration (DD)-matched randomly-selected adult-onset MS (AOMS) patients, together with 208 healthy controls. All subjects underwent neurological evaluation and 3T MRI acquisition. MRI variables were standardized based on healthy controls, to remove effects of age and sex. Associations with DD in POMS and AOMS patients were studied with linear models. Time to reach clinical and MRI milestones was assessed with product-limit approach.Results:At DD=1 year, GMV and WM fractional anisotropy (FA) were abnormal in AOMS but not in POMS patients. Significant interaction of age at onset (POMS vs AOMS) into the association with DD was found for GMV and WM FA. The crossing point of regression lines in POMS and AOMS patients was at 20 years of DD for GMV and 14 for WM FA. For POMS and AOMS patients, median DD was 29 and 19 years to reach Expanded Disability Status Scale=3 (p<0.001), 31 and 26 years to reach abnormal Paced Auditory Serial Addition Task-3 (p=0.01), 24 and 18 years to reach abnormal GMV (p=0.04), and 19 and 17 years to reach abnormal WM FA (p=0.36).Conclusions:Younger patients are initially resilient to MS-related damage. Then, compensatory mechanisms start failing with loss of WM integrity, followed by GM atrophy and finally disability.

scholarly journals Moderating Effect of Insulin Resistance on the Relationship between Gray Matter Volumes and Cognitive Function

2018 ◽  
Vol 7 (11) ◽  
pp. 413 ◽  
Author(s):  
Jiyeon Lee ◽  
Jihyeon Kim ◽  
Seong Shin ◽  
Soowon Park ◽  
Dong Yoon ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Insulin Resistance ◽  
Alzheimer's Disease ◽  
Cognitive Function ◽  
Cognitive Decline ◽  
Gray Matter ◽  
Structural Changes ◽  
Gray Matter Volume ◽  
Volume Loss ◽  
Matter Volume

Background: It is controversial whether exposure to insulin resistance accelerates cognitive deterioration. The present study aimed to investigate the association between insulin resistance and gray matter volume loss to predict the cognitive decline. Methods: We recruited 160 participants (78 with Alzheimer’s disease and 82 without Alzheimer’s disease). Insulin resistance, regional gray matter volume, and cognitive function were assessed. A hierarchical moderated multiple regression (MMR) model was used to determine any associations among insulin resistance, structural changes in the brain, and cognitive decline. Results: The volumes of 7 regions in the gray matter were negatively related to insulin resistance in Alzheimer’s disease (p =0.032). Hierarchical MMR analysis indicated that insulin resistance did not directly affect the cognitive decline but moderated the cognitive decline through the decrease in gray matter volume in the key brain regions, i.e., inferior orbitofrontal gyrus (left), middle cingulate gyrus (right), hippocampus (right), and precuneus (right) (p < 0.05 in each case). Conclusion: Insulin resistance appears to exacerbate the cognitive decline associated with several gray matter volume loss.

P 3 Cerebellar gray matter volume decrease is associated with epileptic seizures in multiple sclerosis

2017 ◽  
Vol 128 (10) ◽  
pp. e327
Author(s):  
M. Grothe ◽  
M. Süße ◽  
F. von Podewils ◽  
S. Langner ◽  
M. Lotze ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Epileptic Seizures ◽  
Matter Volume ◽  
Cerebellar Gray Matter ◽  
Volume Decrease

Hypothalamic gray matter volume loss in hypnic headache

2010 ◽  
Vol 69 (3) ◽  
pp. 533-539 ◽  
Author(s):  
Dagny Holle ◽  
Steffen Naegel ◽  
Sarah Krebs ◽  
Charly Gaul ◽  
Elke Gizewski ◽  
...  
Keyword(s):  
Gray Matter ◽  
Gray Matter Volume ◽  
Volume Loss ◽  
Hypnic Headache ◽  
Matter Volume

The role of global and regional gray matter volume decrease in multiple sclerosis

2016 ◽  
Vol 263 (6) ◽  
pp. 1137-1145 ◽  
Author(s):  
Matthias Grothe ◽  
Martin Lotze ◽  
Sönke Langner ◽  
Alexander Dressel
Keyword(s):  
Multiple Sclerosis ◽  
Gray Matter ◽  
Gray Matter Volume ◽  
Matter Volume ◽  
Volume Decrease

scholarly journals Preservation of gray matter volume in multiple sclerosis patients with the Met allele of the rs6265 (Val66Met) SNP of brain-derived neurotrophic factor

2007 ◽  
Vol 16 (22) ◽  
pp. 2659-2668 ◽  
Author(s):  
Robert Zivadinov ◽  
Bianca Weinstock-Guttman ◽  
Ralph Benedict ◽  
Miriam Tamaño-Blanco ◽  
Sara Hussein ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Gray Matter ◽  
Neurotrophic Factor ◽  
Gray Matter Volume ◽  
Brain Derived Neurotrophic Factor ◽  
Matter Volume ◽  
Multiple Sclerosis Patients
Sign in / Sign up

Export Citation Format

Share Document