Skin nerve misfolded α-synuclein in pure autonomic failure and Parkinson disease

2015 ◽  
Vol 79 (2) ◽  
pp. 306-316 ◽  
Author(s):  
Vincenzo Donadio ◽  
Alex Incensi ◽  
Cristina Piccinini ◽  
Pietro Cortelli ◽  
Maria Pia Giannoccaro ◽  
...  
Keyword(s):  
Parkinson Disease ◽  
Autonomic Failure ◽  
Pure Autonomic Failure

Abstract P381: Understanding the Symptoms of Neurogenic Orthostatic Hypotension: Results From a Survey of Patients and Caregivers

Hypertension ◽  
2017 ◽  
Vol 70 (suppl_1) ◽  
Author(s):  
Lawrence A Hewitt ◽  
Charles H Adler ◽  
Daniel O Claassen ◽  
Christopher H Gibbons ◽  
Satish R Raj
Keyword(s):  
Multiple System Atrophy ◽  
Parkinson Disease ◽  
Orthostatic Hypotension ◽  
Autonomic Failure ◽  
Alpha Synuclein ◽  
Pure Autonomic Failure ◽  
Motor Symptoms ◽  
Neurogenic Orthostatic Hypotension ◽  
The Past ◽  
Increased Risk

Objective: To understand the burden and impact of symptoms of neurogenic orthostatic hypotension (nOH) on patients Background: nOH and its symptoms such as dizziness/lightheadedness are common in patients with Parkinson disease (PD) and other forms of autonomic dysfunction. Methods: An author-designed, US-based survey was conducted by Harris Poll. Eligible participants were aged ≥18 years with PD, multiple system atrophy (MSA), or pure autonomic failure and ≥1 of the following: orthostatic hypotension, nOH, low BP, OH/nOH symptoms, or were caregivers of eligible patients. Results: Most patients (90%) had a diagnosis of PD, and most caregivers (88%) cared for a patient with PD (Table 1) . Patients (34%) and caregivers (49%) reported experiencing nOH symptoms before PD or MSA motor symptoms and >40% indicated that nOH symptoms were more troublesome than motor manifestations of PD or MSA. Less than a quarter (22%) of respondents suggested symptoms were most severe in the morning; more (30%) reported a consistent severity throughout the day. Patients (40%) and caregivers (63%) reported trouble managing symptoms during the day. In the past 12 months, a fall due to nOH symptoms was reported by 57% of patients and 80% of caregivers. Conclusions: These findings suggest that nOH symptoms may predate the onset of motor symptoms in neurodegenerative conditions linked to alpha-synuclein pathology. Many respondents report nOH symptoms are the same severity through the day. Patients with nOH may have trouble managing symptoms and note an increased risk for falls.

93. Phosphorylated α-synuclein biomarker in skin nerves is differently expressed in pure autonomic failure and idiopathic Parkinson disease

2016 ◽  
Vol 127 (4) ◽  
pp. e153-e154
Author(s):  
V. Donadio ◽  
A. Incensi ◽  
C. Piccinini ◽  
P. Cortelli ◽  
M.P. Giannoccaro ◽  
...  
Keyword(s):  
Parkinson Disease ◽  
Autonomic Failure ◽  
Pure Autonomic Failure ◽  
Idiopathic Parkinson Disease

Efficiency of droxydopa in pure autonomic failure

2010 ◽  
Vol 41 (01) ◽  
Author(s):  
M Knosalla ◽  
CA Haensch ◽  
J Wehe ◽  
H Lerch ◽  
J Weis ◽  
...  
Keyword(s):  
Autonomic Failure ◽  
Pure Autonomic Failure

DISTRIBUTION OP LEWY BODIES IN PURE AUTONOMIC FAILURE

1996 ◽  
Vol 55 (5) ◽  
pp. 633
Author(s):  
K. Hague ◽  
S. Caro ◽  
H. Kaufmann ◽  
P. Lento ◽  
S. Morgello
Keyword(s):  
Autonomic Failure ◽  
Lewy Bodies ◽  
Pure Autonomic Failure
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