scholarly journals Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue

2015 ◽  
Vol 78 (5) ◽  
pp. 787-800 ◽  
Author(s):  
Marta Marquié ◽  
Marc D. Normandin ◽  
Charles R. Vanderburg ◽  
Isabel M. Costantino ◽  
Elizabeth A. Bien ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Brain Tissue ◽  
Emission Tomography ◽  
Postmortem Brain ◽  
Positron Emission Tomography Tracer ◽  
Positron Emission ◽  
Postmortem Brain Tissue

scholarly journals Development of the First Potential Nonpeptidic Positron Emission Tomography Tracer for the Imaging of CCR2 Receptors

ChemMedChem ◽  
2020 ◽  
Author(s):  
Stefan Wagner ◽  
Fernando Moura Gatti ◽  
Daniel G. Silva ◽  
Natalia V. Ortiz Zacarias ◽  
Annelien J. M. Zweemer ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Emission Tomography ◽  
Positron Emission Tomography Tracer ◽  
Positron Emission

Measurement of brain tissue oxygenation performed using positron emission tomography scanning to validate a novel monitoring method

2002 ◽  
Vol 96 (2) ◽  
pp. 263-268 ◽  
Author(s):  
Arun K. Gupta ◽  
Peter J. Hutchinson ◽  
Tim Fryer ◽  
Pippa G. Al-Rawi ◽  
Dot A. Parry ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Brain Injury ◽  
Brain Tissue ◽  
Tissue Oxygenation ◽  
Emission Tomography ◽  
Brain Tissue Oxygenation ◽  
Content Type ◽  
Positron Emission ◽  
Pet Scans ◽  
Fine Print

Object. The benefits of measuring cerebral oxygenation in patients with brain injury are well accepted; however, jugular bulb oximetry, which is currently the most popular monitoring technique used has several shortcomings. The goal of this study was to validate the use of a new multiparameter sensor that measures brain tissue oxygenation and metabolism (Neurotrend) by comparing it with positron emission tomography (PET) scanning. Methods. A Neurotrend sensor was inserted into the frontal region of the brain in 19 patients admitted to the neurointensive care unit. After a period of stabilization, the patients were transferred to the PET scanner suite where C15O, 15O2, and H215O PET scans were obtained to facilitate calculation of regional cerebral blood volume, O2 metabolism, blood flow, and O2 extraction fraction (OEF). Patients were given hyperventilation therapy to decrease arterial CO2 by approximately 1 kPa (7.5 mm Hg) and the same sequence of PET scans was repeated. For each scanning sequence, end-capillary O2 tension (PvO2) was calculated from the OEF and compared with the reading of brain tissue O2 pressure (PbO2) provided by the sensor. In three patients the sensor was inserted into areas of contusion and these patients were eliminated from the analysis. In the subset of 16 patients in whom the sensor was placed in healthy brain, no correlation was found between the absolute values of PbO2 and PvO2 (r = 0.2, p = 0.29); however a significant correlation was obtained between the change in PbO2 (ΔPbO2) and the change in PvO2 (ΔPvO2) produced by hyperventilation in a 20-mm region of interest around the sensor (ρ = 0.78, p = 0.0035). Conclusions. The lack of correlation between the absolute values of PbO2 and PvO2 indicates that PbO2 cannot be used as a substitute for PvO2. Nevertheless, the positive correlation between ΔPbO2 and ΔPvO2 when the sensor had been inserted into healthy brain suggests that tissue PO2 monitoring may provide a useful tool to assess the effect of therapeutic interventions in brain injury.

scholarly journals [11C]Para-Aminobenzoic Acid: A Positron Emission Tomography Tracer Targeting Bacteria-Specific Metabolism

2018 ◽  
Vol 4 (7) ◽  
pp. 1067-1072 ◽  
Author(s):  
Christopher A. Mutch ◽  
Alvaro A. Ordonez ◽  
Hecong Qin ◽  
Matthew Parker ◽  
Lauren E. Bambarger ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Emission Tomography ◽  
Aminobenzoic Acid ◽  
Positron Emission Tomography Tracer ◽  
Positron Emission
Sign in / Sign up

Export Citation Format

Share Document