scholarly journals Exercise and Alzheimer's disease biomarkers in cognitively normal older adults

2010 ◽  
Vol 68 (3) ◽  
pp. 311-318 ◽  
Author(s):  
Kelvin Y. Liang ◽  
Mark A. Mintun ◽  
Anne M. Fagan ◽  
Alison M. Goate ◽  
Julie M. Bugg ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Cognitively Normal ◽  
Disease Biomarkers

Relationships between frontal metabolites and Alzheimer's disease biomarkers in cognitively normal older adults

2022 ◽  
Vol 109 ◽  
pp. 22-30
Author(s):  
Antoine Hone-Blanchet ◽  
Anastasia Bohsali ◽  
Lisa C. Krishnamurthy ◽  
Salman Shahid ◽  
Qixiang Lin ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Cognitively Normal ◽  
Disease Biomarkers

scholarly journals Association of CSF Alzheimer's disease biomarkers with postoperative delirium in older adults

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Tamara G. Fong ◽  
Sarinnapha M. Vasunilashorn ◽  
Yun Gou ◽  
Towia A. Libermann ◽  
Simon Dillon ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Postoperative Delirium ◽  
Disease Biomarkers

scholarly journals Financial Capacity and Regional Cerebral Tau in Cognitively Normal Older Adults, Mild Cognitive Impairment, and Alzheimer’s Disease Dementia

2020 ◽  
pp. 1-10
Author(s):  
Christopher Gonzalez ◽  
Nicole S. Tommasi ◽  
Danielle Briggs ◽  
Michael J. Properzi ◽  
Rebecca E. Amariglio ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Older Adults ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Early Stage ◽  
Cognitively Normal ◽  
Financial Capacity ◽  
Posterior Cingulate ◽  
Dorsolateral Prefrontal

Background: Financial capacity is often one of the first instrumental activities of daily living to be affected in cognitively normal (CN) older adults who later progress to amnestic mild cognitive impairment (MCI) and Alzheimer’s disease (AD) dementia. Objective: The objective of this study was to investigate the association between financial capacity and regional cerebral tau. Methods: Cross-sectional financial capacity was assessed using the Financial Capacity Instrument –Short Form (FCI-SF) in 410 CN, 199 MCI, and 61 AD dementia participants who underwent flortaucipir tau positron emission tomography from the Alzheimer’s Disease Neuroimaging Initiative (ADNI). Linear regression models with backward elimination were used with FCI-SF total score as the dependent variable and regional tau and tau-amyloid interaction as predictors of interest in separate analyses. Education, age sex, Rey Auditory Verbal Learning Test Total Learning, and Trail Making Test B were used as covariates. Results: Significant associations were found between FCI-SF and tau regions (entorhinal: p <  0.001; inferior temporal: p <  0.001; dorsolateral prefrontal: p = 0.01; posterior cingulate: p = 0.03; precuneus: p <  0.001; and supramarginal gyrus: p = 0.005) across all participants. For the tau-amyloid interaction, significant associations were found in four regions (amyloid and dorsolateral prefrontal tau interaction: p = 0.005; amyloid and posterior cingulate tau interaction: p = 0.005; amyloid and precuneus tau interaction: p <  0.001; and amyloid and supramarginal tau interaction: p = 0.002). Conclusion: Greater regional tau burden was modestly associated with financial capacity impairment in early-stage AD. Extending this work with longitudinal analyses will further illustrate the utility of such assessments in detecting clinically meaningful decline, which may aid clinical trials of early-stage AD.

Effects of sleep architecture and sleep apnea on Alzheimer's disease biomarkers in cognitively normal elderly

2017 ◽  
Vol 40 ◽  
pp. e336-e337
Author(s):  
A.W. Varga ◽  
K. Kam ◽  
R. Sharma ◽  
A. Parekh ◽  
B. Castillo ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Sleep Apnea ◽  
Sleep Architecture ◽  
Cognitively Normal ◽  
Disease Biomarkers
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