Cerebrospinal fluid of brain trauma patients inhibitsin vitroneuronal network function via NMDA receptors

2009 ◽  
Vol 66 (4) ◽  
pp. 546-555 ◽  
Author(s):  
Frauke Otto ◽  
Sebastian Illes ◽  
Jessica Opatz ◽  
Maurice Laryea ◽  
Stephan Theiss ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Nmda Receptors ◽  
Brain Trauma ◽  
Trauma Patients ◽  
Network Function

scholarly journals High fibrosis indices in cerebrospinal fluid of patients with shunt-dependent post-traumatic chronic hydrocephalus

2016 ◽  
Vol 7 (1) ◽  
Author(s):  
Xu Hao ◽  
Wang Junwen ◽  
Li Jiaqing ◽  
Li Ran ◽  
Zhang Zhuo ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Normal Control ◽  
Brain Trauma ◽  
Enzyme Linked Immunosorbent Assay ◽  
Trauma Patients ◽  
Type I ◽  
Chronic Hydrocephalus ◽  
Procollagen Type ◽  
Post Traumatic ◽  
Tgf Β1

AbstractObjectiveA possible relationship between fibrosis along the route of cerebrospinal fluid (CSF) flow and the subsequent development of hydrocephalus has been indicated in previous studies. These changes in the fibrosis index may reflect the severity of hydrocephalus and could potentially become a diagnostic tool. The object of this study was to analyze the levels of procollagen type I C-terminal propeptide (PICP), procollagen type III N-terminal propeptide (PIIINP), hyaluronic acid (HA), and laminin (LN) in the CSF of patients with post-traumatic hydrocephalus and determine the significance of their presence.Subjects and methodsForty-four patients were included in the study: 24 patients with shunt-dependent post-traumatic hydrocephalus (group A - hydrocephalus group); ten brain trauma patients without any sign of hydrocephalus (group B - trauma group); ten patients without brain trauma and hydrocephalus (group C - normal control group). CSF levels of PICP, PIIINP, HA, LN and transforming growth factor-β1(TGF-β1) were detected using enzyme-linked immunosorbent assay (ELISA).ResultsLevels of PICP, PIIINP, HA, and LN in the group of hydrocephalus patients were significantly higher than those in the post-trauma patients without hydrocephalus (p < 0.05) and normal control patients (p < 0.05). Moreover, the increased levels of PICP, PIIINP, HA, and LN were positively correlated with the level of TGF-β1 (p < 0.05).ConclusionWe demonstrated an increase of fibrosis factors including PICP, PIIINP, HA, and LN, that was positively correlated with TGF-β1 levels. This indicates an important role for the process of fibrosis in the development of post-traumatic chronic hydrocephalus and shows the potential utility of PICP, PIIINP, HA, and LN as a diagnostic index in shunt-dependent post-traumatic chronic hydrocephalus.

Neuronotrophic activities in cerebrospinal fluid of head trauma patients

1984 ◽  
Vol 84 (1) ◽  
pp. 207-218 ◽  
Author(s):  
Frank M. Longo ◽  
Ivan Selak ◽  
John Zovickian ◽  
Marston Manthorpe ◽  
Silvio Varon ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Head Trauma ◽  
Trauma Patients

Diagnostic capabilities of lumbar puncture in patients who have suffered in the past closed brain trauma and neuroinfection

1982 ◽  
Vol 63 (1) ◽  
pp. 46-47
Author(s):  
E. N. Leksin
Keyword(s):  
Cerebrospinal Fluid ◽  
Lumbar Puncture ◽  
Brain Trauma ◽  
Laboratory Research ◽  
Sitting Position ◽  
Csf Dynamics ◽  
Jugular Veins ◽  
Csf Pressure ◽  
The Past ◽  
Diagnostic Capabilities

Our task was to find out the possibility of wider use of lumbar puncture for diagnostic purposes and to unify the registration of the data obtained. To do this, we performed the Queckenstedt test in patients with sequelae of closed brain trauma who had no contraindications to lumbar puncture with the study of CSF dynamics (fundus congestion, Bruns syndrome, bulbar syndrome). The following six indicators were recorded: CSF pressure (LD) in the patient's lying position; LD in the sitting position of the patient; maximum LD with Kvekkenstedt's test (after 10 s of continuous compression of the jugular veins); minimum LD at Kvekkenstedt's test (10 s after the termination of compression of the jugular veins); LD after the release of a certain (usually 3-6 ppm) amount of cerebrospinal fluid required for laboratory research; the total amount of released liquor, usually collected in three test tubes - for clinical (protein, cytosis, sediment microscopy), biochemical (sugar, chlorides, calcium, etc.) and serological (Wasserman river, etc.) studies.

scholarly journals Salt wasting syndrome in brain trauma patients: a pathophysiologic approach using sodium balance and urinary biochemical analysis

BMC Neurology ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Alexandre Lannou ◽  
Cedric Carrie ◽  
Sebastien Rubin ◽  
Gregoire Cane ◽  
Vincent Cottenceau ◽  
...  
Keyword(s):  
Biochemical Analysis ◽  
Brain Trauma ◽  
Sodium Balance ◽  
Trauma Patients ◽  
Salt Wasting ◽  
Wasting Syndrome ◽  
Salt Wasting Syndrome

Outcome of brain trauma patients who have a Glasgow Coma Scale score of 3 and bilateral fixed and dilated pupils in the field

2009 ◽  
Vol 16 (3) ◽  
pp. 153-158 ◽  
Author(s):  
Walter Mauritz ◽  
Johannes Leitgeb ◽  
Ingrid Wilbacher ◽  
Marek Majdan ◽  
Ivan Janciak ◽  
...  
Keyword(s):  
Glasgow Coma Scale ◽  
Scale Score ◽  
Glasgow Coma Scale Score ◽  
Brain Trauma ◽  
Trauma Patients ◽  
Coma Scale

scholarly journals Prognostic significance of intracranial pressure monitoring and intracranial hypertension in severe brain trauma patients

2011 ◽  
Vol 64 (9-10) ◽  
pp. 461-465 ◽  
Author(s):  
Aleksandar Kostic ◽  
Ivan Stefanovic ◽  
Vesna Novak ◽  
Dragan Veselinovic ◽  
Goran Ivanov ◽  
...  
Keyword(s):  
Intracranial Pressure ◽  
Intracranial Hypertension ◽  
Prognostic Significance ◽  
Brain Trauma ◽  
Intracranial Pressure Monitoring ◽  
Control Group ◽  
Trauma Patients ◽  
Pressure Monitoring ◽  
Prognostic Effect ◽  
Significant Difference

Since without prospective randomized studies it is not possible to have a clear attitude towards the importance of intracranial pressure monitoring, this study was aimed at examining the prognostic effect of the intracranial pressure monitoring and intracranial pressure oriented therapy in severe brain trauma patients, and at defining optimal intracranial pressure values for starting the treatment. Two groups of patients were treated in the study, one consisted of 32 patients undergoing intracranial pressure monitoring and the second group of 29 patients without intracranial pressure monitoring in the control group. The study was prospective with groups randomized. There were 53% survivals in the intracranial pressure monitored patients and 34% in the control group, with no significant difference in the survival rate between the two groups (?2=2.11; p=0.15; p>0.05). The average intracranial pressure in the patients with intracranial hypertension who died was 27 mm Hg, while in the patients who survived the average intracranial pressure was significantly lower (Student?s t test: t=2.91; p=0.008; p<0.01) and it was 18 mm Hg. We recommend starting intracranial pressure oriented therapy when the patient?s intracranial pressure exceeds 18 mmHg during 2 hours of monitoring.

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