scholarly journals Detection of human herpesvirus-6 in cerebrospinal fluid of patients with encephalitis

2009 ◽  
Vol 65 (3) ◽  
pp. 257-267 ◽  
Author(s):  
Karen Yao ◽  
Somayeh Honarmand ◽  
Alex Espinosa ◽  
Nahid Akhyani ◽  
Carol Glaser ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Human Herpesvirus ◽  
Human Herpesvirus 6 ◽  
Herpesvirus 6

scholarly journals Human herpesvirus 6 in cerebrospinal fluid of patients infected with HIV: frequency and clinical significance

1999 ◽  
Vol 67 (6) ◽  
pp. 789-792 ◽  
Author(s):  
S. Bossolasco ◽  
R. Marenzi ◽  
H. Dahl ◽  
L. Vago ◽  
M. R. Terreni ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Clinical Significance ◽  
Human Herpesvirus ◽  
Human Herpesvirus 6 ◽  
Herpesvirus 6

Intrathecal human herpesvirus 6 antibodies in multiple sclerosis and other demyelinating diseases presenting as oligoclonal bands in cerebrospinal fluid

2011 ◽  
Vol 237 (1-2) ◽  
pp. 93-97 ◽  
Author(s):  
Jussi O. Virtanen ◽  
Jenna Pietiläinen-Nicklén ◽  
Lasse Uotila ◽  
Markus Färkkilä ◽  
Antti Vaheri ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cerebrospinal Fluid ◽  
Human Herpesvirus ◽  
Demyelinating Diseases ◽  
Oligoclonal Bands ◽  
Human Herpesvirus 6 ◽  
Herpesvirus 6

Serum and cerebrospinal fluid levels of cytokines in acute encephalopathy associated with human herpesvirus-6 infection

2009 ◽  
Vol 31 (10) ◽  
pp. 731-738 ◽  
Author(s):  
Takashi Ichiyama ◽  
Yoshinori Ito ◽  
Masaya Kubota ◽  
Tsutomu Yamazaki ◽  
Kazuyuki Nakamura ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Human Herpesvirus ◽  
Acute Encephalopathy ◽  
Human Herpesvirus 6 ◽  
Cerebrospinal Fluid Levels ◽  
Herpesvirus 6 ◽  
Fluid Levels

scholarly journals Pathogen or Bystander: Clinical Significance of Detecting Human Herpesvirus 6 in Pediatric Cerebrospinal Fluid

2020 ◽  
Vol 58 (5) ◽  
Author(s):  
Utsav Pandey ◽  
Alexander L. Greninger ◽  
Greg R. Levin ◽  
Keith R. Jerome ◽  
Vikram C. Anand ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Clinical Significance ◽  
Clinical Presentation ◽  
Salt Lake ◽  
Antiviral Treatment ◽  
Human Herpesvirus ◽  
Human Herpesvirus 6 ◽  
Disease Etiology ◽  
Radiographic Findings ◽  
Herpesvirus 6

ABSTRACT Human herpesvirus 6 (HHV-6) is an important cause of meningitis and meningoencephalitis. As testing for HHV-6 in cerebrospinal fluid (CSF) is more readily available using the FilmArray Meningitis/Encephalitis panel (FA-ME; BioFire Diagnostics, Salt Lake City, UT), we aimed to determine the clinical significance of detecting HHV-6 in order to identify true infections and to ensure appropriate antiviral initiation. Chart review on 25 patients positive for HHV-6 by FA-ME was performed to determine clinical presentation, comorbidity, treatment, and outcome. The presence of chromosomally integrated HHV-6 (ciHHV-6) DNA was also investigated. Of 1,005 children tested by FA-ME, HHV-6 was detected in 25 (2.5%). Five patients were diagnosed with either HHV-6 meningitis or meningoencephalitis based on HHV-6 detection in CSF, clinical presentation, and radiographic findings. Detection of HHV-6 by FA-ME led to discontinuation of acyclovir within 12.0 h in all 12 patients empirically treated with acyclovir. Six of the 12 patients were started on ganciclovir therapy within 6.8 h; 4 of these were treated specifically for HHV-6 infection, whereas therapy was discontinued in the remaining 2 patients. CSF parameters were not generally predictive of HHV-6 positivity. The presence of ciHHV-6 was confirmed in 3 of 18 patients who could be tested. Five of the 25 patients included in the study were diagnosed with HHV-6 meningitis/meningoencephalitis. FA-ME results led to discontinuation of empirical antiviral treatment in 12 patients and appropriate initiation of ganciclovir in 4 patients. In our institution, detection of HHV-6 using FA-ME led to faster establishment of disease etiology and optimization of antimicrobial therapy.

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