scholarly journals Primary progressive aphasia and the growing role of biomarkers in neurological diagnosis

2008 ◽  
Vol 64 (4) ◽  
pp. 361-364 ◽  
Author(s):  
Jeffrey Cummings
Keyword(s):  
Primary Progressive Aphasia ◽  
Progressive Aphasia ◽  
Primary Progressive

scholarly journals The role of the hippocampus in the semantic variant of primary progressive aphasia: A resting‐state fcMRI study

Hippocampus ◽  
2019 ◽  
Vol 29 (11) ◽  
pp. 1127-1132
Author(s):  
Marianne Chapleau ◽  
Maxime Montembeault ◽  
Mariem Boukadi ◽  
Christophe Bedetti ◽  
Robert Laforce ◽  
...  
Keyword(s):  
Resting State ◽  
Primary Progressive Aphasia ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Semantic Variant

scholarly journals Semantic and lexical features of words dissimilarly affected by non-fluent, logopenic, and semantic primary progressive aphasia

2019 ◽  
Vol 25 (10) ◽  
pp. 1011-1022 ◽  
Author(s):  
Jet M. J. Vonk ◽  
Roel Jonkers ◽  
H. Isabel Hubbard ◽  
Maria Luisa Gorno-Tempini ◽  
Adam M. Brickman ◽  
...  
Keyword(s):  
Semantic Processing ◽  
Mental Lexicon ◽  
Primary Progressive Aphasia ◽  
Word Form ◽  
Lexical Frequency ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Lexical Semantic ◽  
Psycholinguistic Variables

AbstractObjective:To determine the effect of three psycholinguistic variables—lexical frequency, age of acquisition (AoA), and neighborhood density (ND)—on lexical-semantic processing in individuals with non-fluent (nfvPPA), logopenic (lvPPA), and semantic primary progressive aphasia (svPPA). Identifying the scope and independence of these features can provide valuable information about the organization of words in our mind and brain.Method:We administered a lexical decision task—with words carefully selected to permit distinguishing lexical frequency, AoA, and orthographic ND effects—to 41 individuals with PPA (13 nfvPPA, 14 lvPPA, 14 svPPA) and 25 controls.Results:Of the psycholinguistic variables studied, lexical frequency had the largest influence on lexical-semantic processing, but AoA and ND also played an independent role. The results reflect a brain-language relationship with different proportional effects of frequency, AoA, and ND in the PPA variants, in a pattern that is consistent with the organization of the mental lexicon. Individuals with nfvPPA and lvPPA experienced an ND effect consistent with the role of inferior frontal and temporoparietal regions in lexical analysis and word form processing. By contrast, individuals with svPPA experienced an AoA effect consistent with the role of the anterior temporal lobe in semantic processing.Conclusions:The findings are in line with a hierarchical mental lexicon structure with a conceptual (semantic) and a lexeme (word-form) level, such that a selective deficit at one of these levels of the mental lexicon manifests differently in lexical-semantic processing performance, consistent with the affected language-specific brain region in each PPA variant.

scholarly journals The Role of Word Properties in Performance on Fluency Tasks in People with Primary Progressive Aphasia

2019 ◽  
Vol 68 (4) ◽  
pp. 1521-1534 ◽  
Author(s):  
Adrià Rofes ◽  
Vânia de Aguiar ◽  
Bronte Ficek ◽  
Haley Wendt ◽  
Kimberly Webster ◽  
...  
Keyword(s):  
Primary Progressive Aphasia ◽  
Progressive Aphasia ◽  
Primary Progressive

scholarly journals The Role of Language Severity and Education in Explaining Performance on Object and Action Naming in Primary Progressive Aphasia

2018 ◽  
Vol 10 ◽  
Author(s):  
Marianna Riello ◽  
Andreia V. Faria ◽  
Bronte Ficek ◽  
Kimberly Webster ◽  
Chiadi U. Onyike ◽  
...  
Keyword(s):  
Primary Progressive Aphasia ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Action Naming

Role of Cerebrospinal Fluid Biomarkers and (18)F-florbetapir PET Imaging in the Diagnosis of Primary Progressive Aphasia

2019 ◽  
Vol 33 (3) ◽  
pp. 282-284
Author(s):  
Giulia Perini ◽  
Matteo Cotta Ramusino ◽  
Elena Sinforiani ◽  
Diego Franciotta ◽  
Giusppe Trifirò ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Pet Imaging ◽  
Primary Progressive Aphasia ◽  
Progressive Aphasia ◽  
Primary Progressive ◽  
Cerebrospinal Fluid Biomarkers
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