Quantitative magnetic resonance imaging analyses and clinical significance of hyperintense white matter lesions in systemic lupus erythematosus patients

2008 ◽  
Vol 64 (6) ◽  
pp. 635-643 ◽  
Author(s):  
Simone Appenzeller ◽  
Andrea Vasconcelos Faria ◽  
Li Min Li ◽  
Lilian T. L. Costallat ◽  
Fernando Cendes
Keyword(s):  
Magnetic Resonance Imaging ◽  
Systemic Lupus Erythematosus ◽  
White Matter ◽  
Magnetic Resonance ◽  
Lupus Erythematosus ◽  
White Matter Lesions ◽  
Resonance Imaging ◽  
Systemic Lupus ◽  
Quantitative Magnetic Resonance Imaging ◽  
Hyperintense White Matter

White-matter Volume Reduction and the Protective Effect of Immunosuppressive Therapy in Systemic Lupus Erythematosus Patients with Normal Appearance by Conventional Magnetic Resonance Imaging

2010 ◽  
Vol 37 (5) ◽  
pp. 974-986 ◽  
Author(s):  
JIAN XU ◽  
YUQI CHENG ◽  
PEI CHAI ◽  
ZHAOPING LU ◽  
HAIJUN LI ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Systemic Lupus Erythematosus ◽  
White Matter ◽  
Magnetic Resonance ◽  
Immunosuppressive Therapy ◽  
Lupus Erythematosus ◽  
Brain Injuries ◽  
Resonance Imaging ◽  
Visual Interpretation ◽  
Systemic Lupus

Objective.The central nervous system (CNS) is often affected by systemic lupus erythematosus (SLE), but assessment of CNS outcomes using noninvasive cerebral structural measures remains in its infancy. Magnetic resonance imaging (MRI) with expert visual interpretation is critical to diagnosis, but does not permit quantitative measurements. Our pilot study investigated whether quantitative brain volumetric analyses could be used to detect white-matter (WM) abnormalities and responses to treatment in SLE (ClinicalTrials.gov: NCT00703742).Methods.Forty-two pairs of SLE patients and healthy controls underwent high-resolution 3-dimensional structural MRI scans. Combining voxel-based morphometry and region of interest analyses, subtle WM volume abnormalities in whole brains from SLE patients were identified, and regional WM volume was calculated. Associations between WM volume and symptom severity, as well as the effects of immunosuppressive therapy, were then investigated.Results.The WM volume of the SLE group was significantly decreased in the bilateral posterior and anterior crus of the internal capsule (PIC and AIC, respectively), the subgyral right frontal lobe, and left temporal lobe (p < 0.001). Regional WM volume (left PIC and right AIC) was correlated with SLEDAI scores. The WM volume of patients treated with immunosuppressive therapy was greater than that of patients who were never treated with immunosuppressive therapy.Conclusion.Quantitative brain volumetric analyses detect brain injuries in WM for SLE that are not obvious by conventional MRI, and may be adequately sensitive and quantitative to measure the effect of therapeutic interventions in preventing brain injury and outcomes in SLE.

scholarly journals Magnetic resonance imaging of the brain and cerebral proton spectroscopy in patients with systemic lupus erythematosus

1997 ◽  
Vol 40 (1) ◽  
pp. 36-46 ◽  
Author(s):  
R. J. S. Chinn ◽  
I. D. Wilkinson ◽  
M. A. Hall-Craggs ◽  
M. N. J. Paley ◽  
E. Shortall ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Systemic Lupus Erythematosus ◽  
Magnetic Resonance ◽  
Lupus Erythematosus ◽  
Resonance Imaging ◽  
Proton Spectroscopy ◽  
Systemic Lupus ◽  
The Brain
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