Dopamine transporter relation to dopamine turnover in Parkinson's disease: a positron emission tomography study

2007 ◽  
Vol 62 (5) ◽  
pp. 468-474 ◽  
Author(s):  
Vesna Sossi ◽  
Raúl de la Fuente-Fernández ◽  
Michael Schulzer ◽  
Andre R. Troiano ◽  
Thomas J. Ruth ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Positron Emission Tomography ◽  
Parkinson's Disease ◽  
Dopamine Transporter ◽  
Emission Tomography ◽  
Positron Emission Tomography Study ◽  
Dopamine Turnover ◽  
Positron Emission

scholarly journals Changes of Dopamine Turnover in the Progression of Parkinson's Disease as Measured by Positron Emission Tomography: Their Relation to Disease-Compensatory Mechanisms

2004 ◽  
Vol 24 (8) ◽  
pp. 869-876 ◽  
Author(s):  
Vesna Sossi ◽  
Raúl de la Fuente-Fernández ◽  
James E. Holden ◽  
Michael Schulzer ◽  
Thomas J. Ruth ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Positron Emission Tomography ◽  
Parkinson's Disease ◽  
Emission Tomography ◽  
Dopamine Synthesis ◽  
Dopamine Turnover ◽  
Compensatory Mechanisms ◽  
Clinical Onset ◽  
Positron Emission ◽  
Uptake Rate Constant

An increase in dopamine turnover has been shown to occur early in Parkinson's disease (PD). This study investigated changes of dopamine turnover as a function of PD duration using the effective distribution volume (EDV) for dopamine, determined by positron emission tomography with 6-[18F]-fluoro-L-dopa, and compared them with changes in dopamine synthesis and storage ability, quantified with the fluorodopa uptake rate constant Ki. Six healthy subjects, 9 early PD patients (PD1), and 13 advanced PD patients (PD2) participated in the study. In the caudate, the Ki and EDV for PD1 were not significantly different from the normal values, whereas in the putamen Ki was 63% of normal and EDV was only 35%. Between PD1 and PD2 the decline in EDV was higher than that for Ki (caudate 44% and putamen 46% for EDV vs. 21% and 34%, respectively, for Ki). Turnover was higher in the caudate than the putamen in controls, whereas the PD patients exhibited the reverse pattern. This comparison of changes in Ki and EDV as a function of disease progression indicates that a relatively slower decrease in dopamine synthesis and a relatively faster increase in turnover in early disease likely act as compensatory mechanisms, and that the clinical onset of PD reflects a global failure of dopaminergic compensatory mechanisms.

Extrastriatal spreading of microglial activation in Parkinson’s disease: a positron emission tomography study

2016 ◽  
Vol 30 (8) ◽  
pp. 579-587 ◽  
Author(s):  
Tatsuhiro Terada ◽  
Masamichi Yokokura ◽  
Etsuji Yoshikawa ◽  
Masami Futatsubashi ◽  
Satoshi Kono ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Positron Emission Tomography ◽  
Parkinson's Disease ◽  
Microglial Activation ◽  
Emission Tomography ◽  
Positron Emission Tomography Study ◽  
Positron Emission

5-HT1Breceptor imaging and cognition: A positron emission tomography study in control subjects and parkinson's disease patients

Synapse ◽  
2015 ◽  
Vol 69 (7) ◽  
pp. 365-374 ◽  
Author(s):  
Andrea Varrone ◽  
per Svenningsson ◽  
Petter Marklund ◽  
Helena Fatouros-Bergman ◽  
Anton Forsberg ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Positron Emission Tomography ◽  
Parkinson's Disease ◽  
Emission Tomography ◽  
Positron Emission Tomography Study ◽  
Control Subjects ◽  
Positron Emission

Apomorphine effect on pain threshold in Parkinson's disease: A clinical and positron emission tomography study

2010 ◽  
Vol 26 (1) ◽  
pp. 153-157 ◽  
Author(s):  
Estelle Dellapina ◽  
Angélique Gerdelat-Mas ◽  
Fabienne Ory-Magne ◽  
Laure Pourcel ◽  
Monique Galitzky ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Positron Emission Tomography ◽  
Parkinson's Disease ◽  
Pain Threshold ◽  
Emission Tomography ◽  
Positron Emission Tomography Study ◽  
Positron Emission
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