Compulsive drug use linked to sensitized ventral striatal dopamine transmission

2006 ◽  
Vol 59 (5) ◽  
pp. 852-858 ◽  
Author(s):  
Andrew H. Evans ◽  
Nicola Pavese ◽  
Andrew D. Lawrence ◽  
Yen F. Tai ◽  
Silke Appel ◽  
...  
Keyword(s):  
Drug Use ◽  
Striatal Dopamine ◽  
Dopamine Transmission

Regional and Sex Differences in Spontaneous Striatal Dopamine Transmission

2021 ◽  
Author(s):  
James N. Brundage ◽  
Colin P. Mason ◽  
Hillary A. Wadsworth ◽  
Chris S. Finuf ◽  
Josh J. Nelson ◽  
...  
Keyword(s):  
Sex Differences ◽  
Striatal Dopamine ◽  
Dopamine Transmission

scholarly journals Abnormal Striatal Dopamine Transmission in Schizophrenia

2013 ◽  
Vol 20 (3) ◽  
pp. 397-404 ◽  
Author(s):  
Jerome Brunelin ◽  
Shirley Fecteau ◽  
Marie-Francoise Suaud-Chagny
Keyword(s):  
Striatal Dopamine ◽  
Dopamine Transmission

scholarly journals Striatal Dopamine Transmission Is Subtly Modified in Human A53Tα-Synuclein Overexpressing Mice

PLoS ONE ◽  
2012 ◽  
Vol 7 (5) ◽  
pp. e36397 ◽  
Author(s):  
Nicola J. Platt ◽  
Suzana Gispert ◽  
Georg Auburger ◽  
Stephanie J. Cragg
Keyword(s):  
Striatal Dopamine ◽  
Dopamine Transmission

scholarly journals Nigro-striatal dopamine activation lowers behavioral and neuronal phenotypes associated with obsessive-compulsive disorder

2021 ◽  
Author(s):  
Agata Casado-Sainz ◽  
Frederik Gudmundsen ◽  
Simone L. Baerentzen ◽  
Denise Lange ◽  
Annemette Ringsted ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Obsessive Compulsive Disorder ◽  
Dopamine Neurons ◽  
Striatal Dopamine ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Neuronal Populations ◽  
Neuropsychiatric Diseases ◽  
Dopamine Transmission ◽  
Cortical Regions

AbstractNigro-striatal dopamine transmission in the rat dorsomedial striatum (DMS) engages the cortico-striato-thalamo-cortical (CSTC) circuit. Modulation of the CSTC circuit can emulate behavioral and functional aspects of neuropsychiatric diseases, including obsessive compulsive disorder (OCD). Classical pharmacological and neurotoxic manipulations of brain circuits suffer from various drawbacks related to off-target effects and adaptive changes. Chemogenetics, on the other hand, enables a highly selective targeting of specific neuronal populations. In this study, we developed a chemogenetic method for selective activation of dopamine neurons innervating the rat DMS, and used this approach to investigate effects of targeted dopamine activation on CSTC circuit function. We monitored behavioral effects on locomotion, self-grooming, and prepulse inhibition of the startle response, which are stereotypic behaviors related to OCD, as well as effects on metabolic functional connectivity measured by [18F]FDG PET, and regional concentrations of neurochemicals (i.e., glutamate, glutamine, N-acetylaspartate and N-acetylaspartateglutamate) measured by MR spectroscopy. We found that chemogenetic induced nigro-striatal dopamine transmission lowers some of the stereotypic behaviors that are considered hallmarks of OCD. It also disrupts functional connectivity between cortical areas and striatum, and increased total glutamate and N-acetylaspatateglutamate in cortical regions. The results thus establishes the importance of nigro-striatal dopamine transmission in modulation of CSTC function and emphasize DMS dopamine as a possible target for treatment of related neuropsychiatric disorders.One Sentence SummaryChemogenetic nigro-striatal dopamine activation modulates functional connectivity and behaviors related to cortico-striato-thalamo-cortical circuit – perspectives for the treatment of obsessive-compulsive disorder.

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