Rates of cerebral atrophy in autopsy-confirmed progressive supranuclear palsy

2005 ◽  
Vol 59 (1) ◽  
pp. 200-203 ◽  
Author(s):  
Keith A. Josephs ◽  
Jennifer L. Whitwell ◽  
Bradley F. Boeve ◽  
Maria M. Shiung ◽  
Jeffrey L. Gunter ◽  
...  
Keyword(s):  
Progressive Supranuclear Palsy ◽  
Cerebral Atrophy

scholarly journals Alternating flexed-extended posturing in progressive supranuclear palsy

2019 ◽  
Vol 11 (3) ◽  
Author(s):  
Nobuyuki Ishii ◽  
Hitoshi Mochizuki
Keyword(s):  
Magnetic Resonance Imaging ◽  
Nursing Home ◽  
Magnetic Resonance ◽  
Progressive Supranuclear Palsy ◽  
Late Stage ◽  
Cerebral Atrophy ◽  
The Other ◽  
Resonance Imaging ◽  
History Of ◽  
The Brain

A 69-year-old man who had been bedridden in nursing home because of a 5-year history of progressive supranuclear palsy (PSP) was admitted due to aspiration pneumonia. Besides neck dystonia in extension, he showed “alternating flexed–extended posturing”, in which the arm was flexed on one side and extended on the other. Magnetic resonance imaging of the brain revealed global cerebral atrophy that predominantly affected the cortex and midbrain. The mechanisms of complex posturing in late-stage PSP may sometimes be related to decortication and decerebration as well as dystonia, and “alternating flexed–extended posturing” might be one of the phenotypes of pathological progression in PSP.

scholarly journals Clinical deficits correlate with regional cerebral atrophy in progressive supranuclear palsy

Brain ◽  
2005 ◽  
Vol 128 (6) ◽  
pp. 1259-1266 ◽  
Author(s):  
N. J. Cordato ◽  
A. J. Duggins ◽  
G. M. Halliday ◽  
J. G. L. Morris ◽  
C. Pantelis
Keyword(s):  
Progressive Supranuclear Palsy ◽  
Cerebral Atrophy ◽  
Clinical Deficits

scholarly journals The Use of [99mTc]-HM-PAO in the Diagnosis of Primary Degenerative Dementia

1988 ◽  
Vol 8 (1_suppl) ◽  
pp. S123-S126 ◽  
Author(s):  
H. J. Testa ◽  
J. S. Snowden ◽  
D. Neary ◽  
R. A. Shields ◽  
A. W. I. Burjan ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Progressive Supranuclear Palsy ◽  
Frontal Lobe ◽  
Single Photon ◽  
Photon Emission ◽  
Cerebral Atrophy ◽  
Emission Computed Tomography ◽  
Clinical Value ◽  
Diagnosis Of Dementia

The clinical value of single photon emission computed tomography (SPECT) in the differential diagnosis of dementia due to cerebral atrophy was evaluated by comparing the pattern of distribution [99mTc]–HM-PAO in three dementing conditions. Imaging was carried out in 26 patients with suspected Alzheimer's disease, 14 with dementia of the frontal-lobe type, and 13 with progressive supranuclear palsy. Images were evaluated and reported without knowledge of clinical diagnosis with respect to regions of reduced uptake of tracer. Reduced uptake in the posterior cerebral hemispheres was characteristic of Alzheimer's disease, while selective anterior hemisphere abnormalities characterized both dementia of the frontal-lobe type and progressive supranuclear palsy. The latter conditions could be distinguished on the basis of the appearance of integrity of the rim of the frontal cortex. The technique has an important role in the differentiation of degenerative dementias.

scholarly journals MENTALIZING IN FRONTOTEMPORAL DEMENTIA AND PROGRESSIVE SUPRANUCLEAR PALSY

2021 ◽  
Author(s):  
Leonardo de Souza ◽  
Maxime Bertoux ◽  
Luciano Mariano ◽  
Elisa Resende ◽  
Antônio Lúcio Teixeira ◽  
...  
Keyword(s):  
Emotion Recognition ◽  
Progressive Supranuclear Palsy ◽  
Frontotemporal Dementia ◽  
Cerebral Atrophy ◽  
Neural Correlates ◽  
Neural Basis ◽  
Limbic Structures ◽  
Temporal Lobes ◽  
Medial Cortex ◽  
Critical Regions

Background: Mentalizing and emotion recognition are impaired in behavioral variant frontotemporal dementia (bvFTD). It is not clear whether these abilities are disturbed in progressive supranuclear palsy (PSP). Objective: To investigate social cognition (SC) between bvFTD and PSP. The neural basis of SC in PSP and bvFTD groups were also investigated by neuroimaging. Methods: Data from the notification sheet were collected and patients were classified according to current clinical and pathological criteria. Results: Groups did not differ on age, schooling and sex. Compared to controls, bvFTD and PSP patients had reduced scores in all tests of SC. bvFTD and PSP did not differ on measures of SC. PSP and bvFTD had cerebral atrophy in critical regions for SC. The cortical correlates of emotion recognition overlapped in bvFTD and PSP, correlating with frontal medial cortex, insula and limbic structures. PSP and bvFTD patients also displayed similar patterns of brain correlations (anterior temporal lobes) for social norms. The neural correlates of mentalizing were associated with frontal and temporal poles bilaterally, in both bvFTD and PSP. Conclusion:PSP patients exhibit impairment in mentalizing. PSP and bvFTD share clinical, cognitive and neuroimaging features.

Progressive Supranuclear Palsy Quality of Life Scale

2006 ◽  
Author(s):  
A. Schrag ◽  
C. Selai ◽  
N. Quinn ◽  
A. Lees ◽  
I. Litvan ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Progressive Supranuclear Palsy ◽  
Quality Of Life Scale ◽  
Life Scale

Voxel-based morphometry (VBM) analysis in Alzheimer's disease an insight into heterogeneity of cerebral atrophy

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S338-S338
Author(s):  
Akihiko Shiino ◽  
Toshiyuki Watanabe ◽  
Ichiro Akiguchi ◽  
Shigehiro Morikawa ◽  
Toshiro Inubushi ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebral Atrophy ◽  
Voxel Based Morphometry ◽  
Insight Into

Effects of coenzyme Q10 in progressive supranuclear palsy

2008 ◽  
Vol 35 (S 01) ◽  
Author(s):  
M Stamelou ◽  
A Reuss ◽  
U Pilatus ◽  
J Magerkurth ◽  
P Niklowitz ◽  
...  
Keyword(s):  
Progressive Supranuclear Palsy ◽  
Coenzyme Q10

1H MR Spectroscopy in Parkinson's Disease and Progressive Supranuclear Palsy: Preliminary Study

1996 ◽  
Vol 34 (6) ◽  
pp. 711
Author(s):  
Kee Hyun Chang ◽  
Beom Seok Jeon ◽  
In Chan Song ◽  
Dong Sung Kim ◽  
Kwan Hong Min ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Progressive Supranuclear Palsy ◽  
Mr Spectroscopy ◽  
1H Mr Spectroscopy ◽  
Preliminary Study
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