The touch dome in human skin is supplied by different types of nerve fibers

2005 ◽  
Vol 58 (1) ◽  
pp. 88-95 ◽  
Author(s):  
Christina M. Reinisch ◽  
Erwin Tschachler
Keyword(s):  
Human Skin ◽  
Nerve Fibers ◽  
Different Types ◽  
Touch Dome

scholarly journals Three-dimensional Imaging of Nociceptive Intraepidermal Nerve Fibers in Human Skin Biopsies

10.3791/50331 ◽  
2013 ◽  
Author(s):  
Jacqueline R. Dauch ◽  
Chelsea N. Lindblad ◽  
John M. Hayes ◽  
Stephen I. Lentz ◽  
Hsinlin T. Cheng
Keyword(s):  
Human Skin ◽  
Three Dimensional ◽  
Nerve Fibers ◽  
Three Dimensional Imaging ◽  
Skin Biopsies

scholarly journals Critical Factors for In Vivo Measurements of Human Skin by Terahertz Attenuated Total Reflection Spectroscopy

Sensors ◽  
2020 ◽  
Vol 20 (15) ◽  
pp. 4256
Author(s):  
Lixia Wang ◽  
Sayon Guilavogui ◽  
Henghui Yin ◽  
Yiping Wu ◽  
Xiaofei Zang ◽  
...  
Keyword(s):  
Human Skin ◽  
Total Reflection ◽  
Attenuated Total Reflection ◽  
Deep Penetration ◽  
Reference Spectrum ◽  
Critical Factors ◽  
Contact Duration ◽  
In Vivo Measurements ◽  
Different Types

Attenuated total reflection (ATR) geometry is a suitable choice for in vivo measurements of human skin due to the deep penetration of the field into the sample and since it makes it easy to measure the reference spectrum. On the other hand, there are several critical factors that may affect the terahertz (THz) response in these kinds of experiments. Here, we analyse in detail the influence of the following factors: the contact positions between the thumb and the prism, the contact pressure, the contact duration, and the materials of the prism. Furthermore, we use the THz-ATR technology to evaluate different types of handcream and also establish the theoretical model to investigate the reflectivity after interacting with the skin. The results agree well with experimental ones. Our analysis makes it clear the importance of controlling the above factors during measurements to enable reliable THz response and results which, in turn, may be used to monitor water motion in human skin and to predict possible diseases.

Morphometry of dermal nerve fibers in human skin

Neurology ◽  
2011 ◽  
Vol 77 (3) ◽  
pp. 242-249 ◽  
Author(s):  
G. Lauria ◽  
D. Cazzato ◽  
C. Porretta-Serapiglia ◽  
J. Casanova-Molla ◽  
M. Taiana ◽  
...  
Keyword(s):  
Human Skin ◽  
Nerve Fibers

Different types of small nerve fibers in eutopic endometrium and myometrium in women with endometriosis

2007 ◽  
Vol 88 (4) ◽  
pp. 795-803 ◽  
Author(s):  
Natsuko Tokushige ◽  
Robert Markham ◽  
Peter Russell ◽  
Ian S. Fraser
Keyword(s):  
Nerve Fibers ◽  
Eutopic Endometrium ◽  
Different Types ◽  
Small Nerve

New Description of Telocyte Sheaths in the Bovine Uterine Tube: An Immunohistochemical and Scanning Microscopic Study

2016 ◽  
Vol 203 (5) ◽  
pp. 295-315 ◽  
Author(s):  
Hanan H. Abd-Elhafeez ◽  
Soha A. Soliman
Keyword(s):  
Lamina Propria ◽  
Smooth Muscle Actin ◽  
Cell Types ◽  
Estrogen Receptor Α ◽  
Nerve Fibers ◽  
Morphometric Measurements ◽  
Uterine Tube ◽  
Different Types ◽  
S 100 ◽  
Positive Immunostaining

Telocytes are a special type of interstitial cells characterized by distinctive cellular extensions with alternating thin segments (podomers) and dilations (podoms). Telocytes establish contact with various cells and structures, but their role in the regulation of the function of many cell types is still obscure. The aim of the current study was to investigate the morphology, histochemistry, and immunohistochemistry of telocytes, and their distribution, organization, and morphometric measurements in different layers of the adult bovine uterine tube. Telocytes showed positive immunostaining for CD117, S-100 protein, vimentin, desmin, α-smooth muscle actin, tubulin, laminin, estrogen receptor-α, and progesterone receptor. They were organized in different types of sheaths: subepithelial, inner/outer perimuscular, and intramuscular sheaths. Telocytes were scattered in the lamina propria, in the muscular layer, and the serosa. According to their size, they were grouped into different types of telocytes: small, large, and giant telocytes. Small telocytes were the most common type and located in all layers; large telocytes were observed in the epithelium, lamina propria, and inner/outer perimuscular and intramuscular sheaths, and giant telocytes were found in the external layer of the outer perimuscular sheath. Telocytes were connected by thin and thick telopodes (fenestrated membranes). Fenestrated membranes enabled connections between telocytes along the entire muscular wall of the uterine tube. Telocytes established an extensive biological network of different types of cells and structures, including epithelial, muscular, and mast cells, blood vessels, glomus, and nerve fibers. We hypothesize that telocytes help to organize the functional coordination between different types of cells in the uterine tube.

Which nerve fibers mediate the axon reflex flare in human skin?

Neuroreport ◽  
2000 ◽  
Vol 11 (3) ◽  
pp. 645-648 ◽  
Author(s):  
M Schmelz ◽  
K Michael ◽  
C Weidner ◽  
R Schmidt ◽  
H E. orebjörk ◽  
...  
Keyword(s):  
Human Skin ◽  
Nerve Fibers ◽  
Axon Reflex

Distribution of cannabinoid receptor 1 (CB1) and 2 (CB2) on sensory nerve fibers and adnexal structures in human skin

2005 ◽  
Vol 38 (3) ◽  
pp. 177-188 ◽  
Author(s):  
Sonja Ständer ◽  
Martin Schmelz ◽  
Dieter Metze ◽  
Thomas Luger ◽  
Roman Rukwied
Keyword(s):  
Human Skin ◽  
Cannabinoid Receptor ◽  
Sensory Nerve ◽  
Nerve Fibers ◽  
Cannabinoid Receptor 1

scholarly journals Cutaneous overexpression of NT-3 increases sensory and sympathetic neuron number and enhances touch dome and hair follicle innervation.

1996 ◽  
Vol 134 (2) ◽  
pp. 487-497 ◽  
Author(s):  
K M Albers ◽  
T N Perrone ◽  
T P Goodness ◽  
M E Jones ◽  
M A Green ◽  
...  
Keyword(s):  
Sensory Neurons ◽  
Sympathetic Neurons ◽  
Sympathetic Neuron ◽  
Nerve Fibers ◽  
Target Tissue ◽  
Cross Sectional ◽  
Touch Dome ◽  
Sensory Endings

Target-derived influences of nerve growth factor on neuronal survival and differentiation are well documented, though effects of other neurotrophins are less clear. To examine the influence of NT-3 neurotrophin overexpression in a target tissue of sensory and sympathetic neurons, transgenic mice were isolated that overexpress NT-3 in the epidermis. Overexpression of NT-3 led to a 42% increase in the number of dorsal root ganglia sensory neurons, a 70% increase in the number of trigeminal sensory neurons, and a 32% increase in sympathetic neurons. Elevated NT-3 also caused enlargement of touch dome mechanoreceptor units, sensory end organs innervated by slowly adapting type 1 (SA1) neurons. The enlarged touch dome units of the transgenics had an increased number of associated Merkel cells, cells at which SA1s terminate. An additional alteration of skin innervation in NT-3 transgenics was an increased density of myelinated circular endings associated with the piloneural complex. The enhancement of innervation to the skin was accompanied by a doubling in the number of sensory neurons expressing trkC. In addition, measures of nerve fibers in cross-sectional profiles of cutaneous saphenous nerves of transgenics showed a 60% increase in myelinated fibers. These results indicate that in vivo overexpression of NT-3 by the epidermis enhances the number of sensory and sympathetic neurons and the development of selected sensory endings of the skin.

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