Head cooling with mild systemic hypothermia in anesthetized piglets is neuroprotective

2002 ◽  
Vol 53 (1) ◽  
pp. 65-72 ◽  
Author(s):  
James R. Tooley ◽  
Saulius Satas ◽  
Helen Porter ◽  
Ian A. Silver ◽  
Marianne Thoresen
Keyword(s):  
Head Cooling ◽  
Systemic Hypothermia

Does Head Cooling With Mild Systemic Hypothermia Affect Requirement for Blood Pressure Support?

PEDIATRICS ◽  
2009 ◽  
Vol 123 (3) ◽  
pp. 1031-1036 ◽  
Author(s):  
M. R. Battin ◽  
M. Thoresen ◽  
E. Robinson ◽  
R. A. Polin ◽  
A. D. Edwards ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Pressure Support ◽  
Head Cooling ◽  
Systemic Hypothermia

Early head cooling in newborn piglets is neuroprotective even in the absence of profound systemic hypothermia

2003 ◽  
Vol 45 (5) ◽  
pp. 522-529 ◽  
Author(s):  
Osuke Iwata ◽  
Sachiko Iwata ◽  
Masanori Tamura ◽  
Tomohiko Nakamura ◽  
Masatoshi Sugiura ◽  
...  
Keyword(s):  
Newborn Piglets ◽  
Head Cooling ◽  
Systemic Hypothermia

Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial

The Lancet ◽  
2005 ◽  
Vol 365 (9460) ◽  
pp. 663-670 ◽  
Author(s):  
P GLUCKMAN ◽  
J WYATT ◽  
D AZZOPARDI ◽  
R BALLARD ◽  
A EDWARDS ◽  
...  
Keyword(s):  
Randomised Trial ◽  
Neonatal Encephalopathy ◽  
Head Cooling ◽  
Systemic Hypothermia

Selective head cooling with mild systemic hypothermia after neonatal encephalopathy: multicentre randomised trial

The Lancet ◽  
2005 ◽  
Vol 365 (9460) ◽  
pp. 663-670 ◽  
Author(s):  
Peter D Gluckman ◽  
John S Wyatt ◽  
Denis Azzopardi ◽  
Roberta Ballard ◽  
A David Edwards ◽  
...  
Keyword(s):  
Randomised Trial ◽  
Neonatal Encephalopathy ◽  
Head Cooling ◽  
Systemic Hypothermia

Treatment of Term Infants With Head Cooling and Mild Systemic Hypothermia (35.0 C and 34.5 C) After Perinatal Asphyxia

PEDIATRICS ◽  
2003 ◽  
Vol 111 (2) ◽  
pp. 244-251 ◽  
Author(s):  
M. R. Battin ◽  
J. Penrice ◽  
T. R. Gunn ◽  
A. J. Gunn
Keyword(s):  
Perinatal Asphyxia ◽  
Term Infants ◽  
Head Cooling ◽  
Systemic Hypothermia

scholarly journals Minimal systemic hypothermia combined with selective head cooling evaluated in a pig model of hypoxia-ischemia

2015 ◽  
Vol 77 (5) ◽  
pp. 674-680 ◽  
Author(s):  
Nicholas Hoque ◽  
Xun Liu ◽  
Ela Chakkarapani ◽  
Marianne Thoresen
Keyword(s):  
Pig Model ◽  
Head Cooling ◽  
Hypoxia Ischemia ◽  
Systemic Hypothermia

Brain temperature in newborn piglets under selective head cooling with minimal systemic hypothermia

2003 ◽  
Vol 45 (2) ◽  
pp. 163-168 ◽  
Author(s):  
Osuke Iwata ◽  
Sachiko Iwata ◽  
Masanori Tamura ◽  
Tomohiko Nakamura ◽  
Masatoshi Sugiura ◽  
...  
Keyword(s):  
Brain Temperature ◽  
Newborn Piglets ◽  
Head Cooling ◽  
Systemic Hypothermia

Neurological Outcome at 30 Months of Age after Mild Hypothermia via Selective Head Cooling in Term Neonates with Perinatal Asphyxia Using Low-Cost CoolCap: A Single-Center Randomized Control Pilot Trial in India

2017 ◽  
Vol 15 (04) ◽  
pp. 157-165 ◽  
Author(s):  
Nirmalya Sarkar ◽  
Mala Bhattacharya ◽  
Suprit Basu ◽  
Debashish Sanyal ◽  
Anish Chatterjee ◽  
...  
Keyword(s):  
Adverse Effects ◽  
Perinatal Asphyxia ◽  
Low Cost ◽  
Secondary Outcome ◽  
Control Group ◽  
Single Center ◽  
Risk Of Death ◽  
Head Cooling ◽  
Systemic Hypothermia ◽  
Randomized Control

AbstractThe objective of this study was to determine the effectiveness and safety of mild systemic hypothermia by selective head cooling in hospital born neonates with hypoxic-ischemic encephalopathy using low-cost CoolCap. The primary outcome was to determine whether selective head cooling reduces neonatal mortality and neurodevelopmental delay (NDD) at > 30 months of age. The secondary outcome was to determine the serious adverse effects during selective head cooling such as thrombocytopenia requiring platelets transfusion, renal and hepatic dysfunction, bradycardia, hypoglycemia, and dyselectrolytemia (hyperkalemia, hyponatremia, and hypocalcemia). This is a single-center randomized control trial. The risk ratios, risk differences, and numbers needed to treat plus 95% confidence interval (CI) were measured. This study was done at the tertiary care perinatal center. Inborn neonates with ≥ 37 completed weeks of gestation with indicators of perinatal asphyxia and moderate to severe clinical encephalopathy were randomly allocated to hypothermia (n = 30) or standard care (n = 30) groups. The neonates were subjected to mild systemic hypothermia via selective head cooling using ice caps, the target rectal temperature being 34 to 35°C for 72 hours. Therapeutic hypothermia reduced the risk of death and NDD at ≥ 30 months of age: 6 of 30 infants (20%) in the hypothermia group and 18 of 30 infants (60%) in the control group died or had a NDD at ≥ 30 months (risk ratio: 0.33 [95% CI: 0.15–0.72]; p = 0 0.0015). The mortality rate decreased, and the survival rate free of any sensorineural disability increased. The benefits were statistically significant in moderately asphyxiated infants. Adverse effects of hypothermia were minimal. Selective head cooling with mild systemic hypothermia in term asphyxiated neonates is safe and inexpensive in low-resource setting. Hypothermia showed statistically significant reduction in mortality and NDD at ≥ 30 months of age when commenced within 6 hours of birth and was not associated with serious adverse effects. The Institutional Clinical Trial Registry number is CNMC/ETHI/317/P.

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