Association between venous blood lactate levels and differences in quantitative capillary refill time

Four mature horses were used to test the effects of two doses (50 and 200 mg) of intravenously administered cocaine on hemodynamics and selected indexes of performance [maximal heart rate (HRmax), treadmill velocity at HRmax, treadmill velocity needed to produce a blood lactate concentration of 4 mmol/l, maximal mixed venous blood lactate concentration, maximal treadmill work intensity, and test duration] measured during an incremental treadmill test. Both doses of cocaine increased HRmax approximately 7% (P < 0.05). Mean arterial pressure was 30 mmHg greater (P < 0.05) during the 4- to 7-m/s steps of the exercise test in the 200-mg trial. Neither dose of cocaine had an effect on the responses to exertion of right atrial pressure, right ventricular pressure, or maximal change in right ventricular pressure over time. Maximal mixed venous blood lactate concentration increased 41% (P < 0.05) with the 50-mg dose and 75% (P < 0.05) with the 200-mg dose during exercise. Administration of cocaine resulted in decreases (P < 0.05) in the treadmill velocity needed to produce a blood lactate concentration of 4 mmol/l from 6.9 +/- 0.5 and 6.8 +/- 0.9 m/s during the control trials to 4.4 +/- 0.1 m/s during the 200-mg cocaine trial. Cocaine did not alter maximal treadmill work intensity (P > 0.05); however, time to exhaustion increased by approximately 92 s (15%; P < 0.05) during the 200-mg trial.(ABSTRACT TRUNCATED AT 250 WORDS)

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Effects of whole-body neuromuscular electrical stimulation device on hemodynamics, arrhythmia, and sublingual microcirculation

Heart and Vessels ◽

10.1007/s00380-020-01755-1 ◽

2021 ◽

Author(s):

Megumi Hoshiai ◽

Kaori Ochiai ◽

Yuma Tamura ◽

Tomoki Tsurumi ◽

Masato Terashima ◽

...

Keyword(s):

Electrical Stimulation ◽

Blood Glucose ◽

Blood Lactate ◽

Neuromuscular Electrical Stimulation ◽

Whole Body ◽

Left Ventricular Ejection ◽

Sublingual Microcirculation ◽

Blood Fluidity ◽

Lactate Levels ◽

Blood Lactate Levels

AbstractNeuromuscular electrical stimulation has been used to treat cardiovascular diseases and other types of muscular dysfunction. A novel whole-body neuromuscular electrical stimulation (WB-NMES) wearable device may be beneficial when combined with voluntary exercises. This study aimed to investigate the safety and effects of the WB-NMES on hemodynamics, arrhythmia, and sublingual microcirculation. The study included 19 healthy Japanese volunteers, aged 22–33 years, who were not using any medication. Electrocardiogram (ECG), echocardiography, and blood sampling were conducted before a 20-min WB-NMES session and at 0 and 10 min after termination of WB-NMES. Their tolerable maximum intensity was recorded using numeric rating scale. Arrhythmia was not detected during neuromuscular electrical stimulation or during 10 min of recovery. Blood pressure, heart rate, left ventricular ejection fraction, and diastolic function remained unchanged; however, mild mitral regurgitation was transiently observed during WB-NMES in a single male participant. A decrease in blood glucose and an increase in blood lactate levels were observed, but no changes in blood fluidity, sublingual microcirculation, blood levels of noradrenaline, or oxidative stress were shown. WB-NMES is safe and effective for decreasing blood glucose and increasing blood lactate levels without changing the blood fluidity or microcirculation in healthy people.

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Admission blood lactate levels of patients diagnosed with cerebrovascular disease effects on short and long‐term mortality risk

International Journal of Clinical Practice ◽

10.1111/ijcp.14161 ◽

2021 ◽

Author(s):

Cemalettin Sakal ◽

Rohat AK ◽

Abdullah Taşçı ◽

Ecem Deniz Kırkpantur ◽

Ebru Ünal Akoğlu ◽

...

Keyword(s):

Cerebrovascular Disease ◽

Blood Lactate ◽

Mortality Risk ◽

Short And Long Term ◽

Lactate Levels ◽

Blood Lactate Levels ◽

Long Term Mortality

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Serial blood lactate levels as a prognostic factor for sepsis mortality

Paediatrica Indonesiana ◽

10.14238/pi54.3.2014.168-73 ◽

2014 ◽

Vol 54 (3) ◽

pp. 168

Author(s):

Keswari Aji Patriawati ◽

Nurnaningsih Nurnaningsih ◽

Purnomo Suryantoro

Keyword(s):

Blood Lactate ◽

Lactate Clearance ◽

Major Health Problem ◽

Major Health ◽

Serial Blood ◽

Factors Associated ◽

Relative Risks ◽

Increased Risk ◽

Lactate Levels ◽

Blood Lactate Levels

Background Sepsis is a major health problem in children and aleading cause of death. In recent decades, lactate has been studiedas a biomarker for sepsis, and as an indicator of global tissuehypoxia, increased glycolysis, endotoxin effect, and anaerobicmetabolism. Many studies h ave shown both high levels andincreased serial blood lactate level measurements to be associatedwith increased risk of sepsis mortality.Objective To evaluate serial blood lactate levels as a prognosticfactor for sepsis mortality.Methods We performed an observational, prospective study in thePediatric Intensive Care Unit (PICU) at DR. Sardjito Hospital,Yogyakarta from July to November 2012. We collected serialblood lactate specimens of children with sepsis, first at the time ofadmission, followed by 6 and 24 hours later. The outcome measurewas mortality at the end ofintensive care. Relative risks and 95%confidence intervals of the factors associated with mortality werecalculated using univariate and multivariate analyses.Results Sepsis was found in 91 (50.3%) patients admitted tothe PIW , of whom 75 were included in this study. Five patients(6. 7%) died before the 24-hour lactate collection and 39 patients(52.0%) died during the study. Blood lactate levels of ~ 4mmol;Lat the first and 24-hour specimens were associated with mortality(RR 2.9; 95%CI 1.09 to 7 .66 and RR 4.92; 95%CI 1.77 to 13.65,respectively). Lactate clearance of less than 10% at 24 hours(adjusted RR 5.3; 95% CI 1.1 to 24.5) had a significantly greaterrisk fo llowed by septic shock (adjusted RR 1.54; 95%CI 1.36 to6.4 7) due to mortality.Conclusion In children with sepsis there is a greater risk of mortalityin those with increasing or persistently high serial blood lactatelevels, as shown by less than 10% lactate clearance at 24-hours afterPIW admission.

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Oxamate Enhances the Anti-Inflammatory and Insulin-Sensitizing Effects of Metformin in Diabetic Mice

Pharmacology ◽

10.1159/000478909 ◽

2017 ◽

Vol 100 (5-6) ◽

pp. 218-228 ◽

Cited By ~ 2

Author(s):

Mu-chao Wu ◽

Wei-ran Ye ◽

Yi-jia Zheng ◽

Shan-shan Zhang

Keyword(s):

Blood Lactate ◽

Cell Mass ◽

Lactate Production ◽

Beta Cell Mass ◽

Serum Lactate ◽

Blood Levels ◽

Anti Inflammatory ◽

Lactate Levels ◽

Blood Lactate Levels

Metformin (MET) is the first-line drug for treating type 2 diabetes mellitus (T2DM). However, MET increases blood lactate levels in patients with T2DM. Lactate possesses proinflammatory properties and causes insulin resistance (IR). Oxamate (OXA), a lactate dehydrogenase inhibitor, can decrease tissue lactate production and blood lactate levels. This study was conducted to examine the effects of the combination of OXA and MET on inflammation, and IR in diabetic db/db mice. Supplementation of OXA to MET led to lowered tissue lactate production and serum lactate levels compared to MET alone, accompanied with further decreased tissue and blood levels of pro-inflammatory cytokines, along with better insulin sensitivity, beta-cell mass, and glycemic control in diabetic db/db mice. These results show that OXA enhances the anti-inflammatory and insulin-sensitizing effects of MET through the inhibition of tissue lactate production in db/db mice.

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