scholarly journals The qSOFA requires validation as a promptly applicable clinical criterion

2017 ◽  
Vol 4 (3) ◽  
pp. 225-226
Author(s):  
Shigeki Kushimoto ◽  
Satoshi Gando ◽  
Hiroshi Ogura
Keyword(s):  
PLoS ONE ◽  
2021 ◽  
Vol 16 (7) ◽  
pp. e0252322
Author(s):  
Taiana Cunha Ribeiro ◽  
Emerson Kiyoshi Honda ◽  
Daniel Daniachi ◽  
Ricardo de Paula Leite Cury ◽  
Cely Barreto da Silva ◽  
...  

Background In the absence of a gold standard criterion for diagnosing prosthetic joint infections (PJI), sonication of the removed implant may provide superior microbiological identification to synovial fluid and peri-implant tissue cultures. The aim of this retrospective study was to assess the role of sonication culture compared to tissue cultures for diagnosing PJI, using different consensus and international guidelines for PJI definition. Methods Data of 146 patients undergoing removal of hip or knee arthroplasties between 2010 and 2018 were retrospectively reviewed. The International Consensus Meeting (ICM-2018), Musculoskeletal Infection Society (MSIS), Infectious Diseases Society of America (IDSA), the European Bone and Joint Infection Society (EBJIS), and a modified clinical criterion, were used to compare the performance of microbiological tests. McNemar´s test and proportion comparison were employed to calculate p-value. Results Overall, 56% (82/146) were diagnosed with PJI using the clinical criteria. Out of these cases, 57% (47/82) tested positive on tissue culture and 93% (76/82) on sonication culture. Applying this clinical criterion, the sensitivity of sonication fluid and tissue cultures was 92.7% (95% CI: 87.1%- 98.3%) and 57.3% (95% CI: 46.6%-68.0%) (p<0.001), respectively. When both methods were combined for diagnosis (sonication and tissue cultures) sensitivity reached 96.3% (95% CI: 91.5%-100%). Sonication culture and the combination of sonication with tissue cultures, showed higher sensitivity rates than tissue cultures alone for all diagnostic criteria (ICM-18, MSIS, IDSA and EBJIS) applied. Conversely, tissue culture provided greater specificity than sonication culture for all the criteria assessed, except for the EBJIS criteria, in which sonication and tissue cultures specificity was 100% and 95.3% (95% CI: 87.8–100%), respectively (p = 0.024). Conclusions In a context where diagnostic criteria available have shortcomings and tissue cultures remain the gold standard, sonication cultures can aid PJI diagnosis, especially when diagnostic criteria are inconclusive due to some important missing data (joint puncture, histology).


1939 ◽  
Vol 22 (10) ◽  
pp. 501-508
Author(s):  
MATTHEW LUCKIESH ◽  
FRANK K. MOSS
Keyword(s):  

PEDIATRICS ◽  
1978 ◽  
Vol 62 (3) ◽  
pp. 307-311
Author(s):  
Pentti Kero ◽  
Kari Antila ◽  
Veli Ylitalo ◽  
llkka Välimäki

Heart rate variation (HRV) was measured in 12 children with brain death. Computer analysis demonstrated an overall heart rate variation (RMSM) of 3.5 to 9.6 msec (mean, 6.0 msec). The respective figures for beat-to-beat variation (RMSSD) were 4 to 16 msec (mean, 7.7 msec). Normal infants (RMSM, 20 to 30 msec) and children (RMSM, 50 to 90 msec) and infants with respiratory distress syndrome (RMSM, 10 to 20 msec) have a clearly higher HRV than those with brain death. In all subjects a periodic component of the HRV with a cycle length of 5.9 ± 0.26 seconds was discovered. In five patients an additional periodic component was found that corresponded exactly to the rate of artificial respiration. This study demonstrated the value of accurate digital techniques in the characterization of fixed heart rate in decerebration. This phenomenon could be considered one clinical criterion of brain death.


BDJ Open ◽  
2017 ◽  
Vol 3 (1) ◽  
Author(s):  
Nádia Antunes Poitevin ◽  
Mariana Sudati Rodrigues ◽  
Karen Loureiro Weigert ◽  
Carmen Lúcia Rodrigues Macedo ◽  
Rubem Beraldo dos Santos

2007 ◽  
Vol 3 (3S_Part_2) ◽  
pp. S140-S140 ◽  
Author(s):  
Toshimitsu Musha ◽  
Takeo Takao
Keyword(s):  

1939 ◽  
Vol 22 (6) ◽  
pp. 616-621 ◽  
Author(s):  
Matthew Luckiesh ◽  
Frank K. Moss
Keyword(s):  

2019 ◽  
Vol 12 (2) ◽  
pp. 169-179
Author(s):  
Murilo Ricardo Zibetti ◽  
Andressa Hermes Pereira ◽  
Ana Julia Lehnen ◽  
Gabriela Zuñeda Peres Duarte ◽  
Fabiula de Fátima Machado dos Santos ◽  
...  

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