scholarly journals Radiation‐induced oral mucositis hamster model using a linear accelerator enhances clinical relevance of preclinical studies for treatment strategy investigation

2021 ◽  
Author(s):  
Carolyn T. Jordan ◽  
Emily M. Bradford ◽  
Dennis C. Cheek ◽  
Mahesh Kudrimoti ◽  
Craig S. Miller ◽  
...  
Keyword(s):  
Oral Mucositis ◽  
Treatment Strategy ◽  
Clinical Relevance ◽  
Linear Accelerator ◽  
Preclinical Studies ◽  
Hamster Model ◽  
Radiation Induced

Modulation of radiation-induced oral mucositis by pentoxifylline: Preclinical studies

2014 ◽  
Vol 191 (3) ◽  
pp. 242-247 ◽  
Author(s):  
Sylvia Gruber ◽  
Margret Schmidt ◽  
Eva Bozsaky ◽  
Kathrin Wolfram ◽  
Julia Haagen ◽  
...  
Keyword(s):  
Oral Mucositis ◽  
Preclinical Studies ◽  
Radiation Induced

Effect of a mouth rinse formulation with human trefoil factor 1-secreting Lactococcus lactis in experimental oral mucositis in hamsters

2009 ◽  
Vol 27 (15_suppl) ◽  
pp. e14570-e14570 ◽  
Author(s):  
P. Rottiers ◽  
S. Caluwaerts ◽  
L. Steidler ◽  
K. Vandenbroucke ◽  
B. Watkins ◽  
...  
Keyword(s):  
Lactococcus Lactis ◽  
Oral Mucosa ◽  
Oral Mucositis ◽  
Systemic Exposure ◽  
Pharmacokinetic Studies ◽  
Clinical Approach ◽  
Mouth Rinse ◽  
Weight Changes ◽  
Hamster Model ◽  
Radiation Induced

e14570 Background: Oral mucositis (OM) is a painful and dose-limiting toxicity of cancer chemotherapy and irradiation, characterized by breakdown of the oral mucosa. Trefoil factors (TFFs) are involved in protecting and healing mucosal tissue, and might thus represent a pharmacological tool for treatment of OM. Local delivery of recombinant TFFs at the oral mucosa by living, genetically modified Lactococcus (L.) lactis bacteria (ActoBiotics) seems a promising, safe and cost-effective clinical approach for the prevention and attenuation of oral mucositis. Methods: An environmentally contained Lactococcus lactis strain (AG013), engineered to express human (h)TFF1, was formulated for topical administration in the form of a mouth rinse. Efficacy of AG013 was assessed in a clinically relevant hamster model of acute, radiation-induced OM. The dosing regimen was 1.3 x 109 CFU/dose, once (qd) or three rinses (tid) daily, from day 0 (=day of radiation) to day 18. OM was scored from day 6 to day 28 using the WHO grading scale, and compared to the score of placebo-treated hamsters. The viability and survival of live L. lactis and the pharmacokinetics of the hTFF1 secreted were studied in healthy and OM hamsters. Results: Topical application of AG013 to the oral mucosa significantly reduced the severity and course of radiation-induced OM. In the AG013-treated groups, the number of animals days with ulcerative mucositis (grade 3 or higher) was significantly reduced to 27.5% and 30.8% (qd and tid respectively; P < 0.001), compared to 45.8 % in the placebo-treated group. Based on the observed survival and weight changes, AG013 appeared to be well-tolerated. Pharmacokinetic studies demonstrated that both living L. lactis and the hTFF1 secreted could be recovered from the administration site, for maximum 24 hours post-dosing, without systemic exposure. Conclusions: Oral administration of AG013 is safe and effective in reducing the severity and the course of OM in the hamster model, and therefore supports proof-of-concept for a mouth rinse formulation of AG013 to treat OM patients. [Table: see text]

scholarly journals Systemic administration of heparin ameliorates radiation-induced oral mucositis—preclinical studies in mice

2018 ◽  
Vol 194 (7) ◽  
pp. 686-692 ◽  
Author(s):  
Maria Kowaliuk ◽  
Eva Bozsaky ◽  
Sylvia Gruber ◽  
Peter Kuess ◽  
Wolfgang Dörr
Keyword(s):  
Oral Mucositis ◽  
Systemic Administration ◽  
Preclinical Studies ◽  
Radiation Induced

Effect of topical clonidine on the duration and severity of radiation-induced oral mucositis (OM) in a translational hamster model.

2014 ◽  
Vol 32 (15_suppl) ◽  
pp. 10091-10091 ◽  
Author(s):  
Pierre Attali ◽  
Vanessa Roulet ◽  
Greg Lyng ◽  
Lorraine Zakin ◽  
Veronique Trochon-Joseph ◽  
...  
Keyword(s):  
Oral Mucositis ◽  
Hamster Model ◽  
Radiation Induced ◽  
Topical Clonidine

Effects of dexpanthenol with or without Aloe vera extract on radiation-induced oral mucositis: Preclinical studies

2005 ◽  
Vol 81 (3) ◽  
pp. 243-250 ◽  
Author(s):  
W Dörr ◽  
S Schlichting ◽  
MA Bray ◽  
IR Flockhart ◽  
JW Hopewell
Keyword(s):  
Oral Mucositis ◽  
Aloe Vera ◽  
Preclinical Studies ◽  
Radiation Induced

scholarly journals Early inflammatory changes in radiation-induced oral mucositis

2017 ◽  
Vol 193 (6) ◽  
pp. 499-507 ◽  
Author(s):  
Sylvia Gruber ◽  
Eva Bozsaky ◽  
Eva Roitinger ◽  
Karoline Schwarz ◽  
Margret Schmidt ◽  
...  
Keyword(s):  
Oral Mucositis ◽  
Radiation Induced ◽  
Inflammatory Changes

scholarly journals Efficacy of Traditional Chinese Medicine in Treatment and Prophylaxis of Radiation-Induced Oral Mucositis in Patients Receiving Radiotherapy: A Randomized Controlled Trial

2017 ◽  
Vol 17 (2) ◽  
pp. 444-450 ◽  
Author(s):  
Cong Wang ◽  
Peiguo Wang ◽  
Huaqiang Ouyang ◽  
Jing Wang ◽  
Lining Sun ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Chinese Medicine ◽  
Treatment Group ◽  
Traditional Chinese Medicine ◽  
Body Mass ◽  
Oral Mucositis ◽  
Visual Analysis ◽  
Control Group ◽  
Oral Pain ◽  
Radiation Induced

Objective: To estimate the efficacy of traditional Chinese medicine (Chining decoction, CHIN) for radiation-induced oral mucositis in patients with head and neck cancer. Methods: From May 2014 to December 2015, 70 consecutive patients were randomly assigned to receive CHIN (treatment group) or recombinant human epidermal growth factor (rhEGF) spray (control group) at a 1:1 ratio. CHIN was administered to treatment group from the first day of radiotherapy until the completion of radiotherapy. Simultaneously, the rhEGF spray was administered to control group on the oral mucosa of irradiated area. The clinical benefit was determined by gradation of mucositis (Common Terminology Criteria for Adverse Events v4.0), oral pain, and xerostomia (visual analysis scale) for each week during radiotherapy. Body mass index was evaluated before and after radiotherapy. Results: Patients in the treatment group had prominent remission of oral pain and grade of mucositis on each observing point compared with those in control group ( P < .01). Xerostomia was decreased notably in treatment group compared with control group ( P < .01). Body mass index in the treatment group exhibited advantage over control group after radiotherapy, but there was no statistical significance (19.8 ± 3.26 vs 18.8 ± 2.5 kg/m2, P = .153, >.05). Conclusions: CHIN presented an obvious advantage in preventing radiation-induced oral mucositis compared with rhEGF spray.

Sign in / Sign up

Export Citation Format

Share Document