Impact of increased APP gene dose in Down syndrome and the Dp16 mouse model

2021 ◽  
Author(s):  
Mariko Sawa ◽  
Cassia Overk ◽  
Ann Becker ◽  
Dominique Derse ◽  
Ricardo Albay ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Mouse Model ◽  
Gene Dose ◽  
App Gene

scholarly journals Evidence that increased Kcnj6 gene dose is necessary for deficits in behavior and dentate gyrus synaptic plasticity in the Ts65Dn mouse model of Down syndrome

2017 ◽  
Vol 103 ◽  
pp. 1-10 ◽  
Author(s):  
Alexander M. Kleschevnikov ◽  
Jessica Yu ◽  
Jeesun Kim ◽  
Larisa V. Lysenko ◽  
Zheng Zeng ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Synaptic Plasticity ◽  
Mouse Model ◽  
Dentate Gyrus ◽  
Ts65dn Mouse ◽  
Gene Dose

scholarly journals Perturbation of fetal hematopoiesis in a mouse model of Down syndrome’s transient myeloproliferative disorder

Blood ◽  
2013 ◽  
Vol 122 (6) ◽  
pp. 988-998 ◽  
Author(s):  
Yehudit Birger ◽  
Liat Goldberg ◽  
Timothy M. Chlon ◽  
Benjamin Goldenson ◽  
Inna Muler ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Mouse Model ◽  
Myeloproliferative Disorder ◽  
Transient Myeloproliferative Disorder ◽  
Terminal Domain ◽  
Key Points ◽  
Fetal Hematopoiesis ◽  
Fetal Erythropoiesis

Key Points Transient expansion of fetal megaerythroid progenitors in ERG/Gata1s mouse is biologically similar to Down syndrome TMD. The N-terminal domain of GATA1 and the downregulation of ERG expression are essential for normal fetal erythropoiesis.

scholarly journals Low dose EGCG treatment beginning in adolescence does not improve cognitive impairment in a Down syndrome mouse model

2015 ◽  
Vol 138 ◽  
pp. 70-79 ◽  
Author(s):  
Megan Stringer ◽  
Irushi Abeysekera ◽  
Karl J. Dria ◽  
Randall J. Roper ◽  
Charles R. Goodlett
Keyword(s):  
Down Syndrome ◽  
Cognitive Impairment ◽  
Mouse Model ◽  
Low Dose ◽  
Egcg Treatment

scholarly journals Increased cortical synaptic activation of TrkB and downstream signaling markers in a mouse model of Down Syndrome

2015 ◽  
Vol 77 ◽  
pp. 173-190 ◽  
Author(s):  
R.L. Nosheny ◽  
P.V. Belichenko ◽  
B.L. Busse ◽  
A.M. Weissmiller ◽  
V. Dang ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Mouse Model ◽  
Synaptic Activation ◽  
Downstream Signaling
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