scholarly journals Association of Life's Simple 7 with incident dementia and its modification by the apolipoprotein E genotype

2021 ◽  
Author(s):  
Jing Guo ◽  
Adam M. Brickman ◽  
Jennifer J. Manly ◽  
Christiane Reitz ◽  
Nicole Schupf ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Incident Dementia ◽  
Life’S Simple 7 ◽  
Life's Simple 7 ◽  
Apolipoprotein E Genotype

scholarly journals Cerebrospinal fluid biomarkers and apolipoprotein E genotype in cerebral amyloid angiopathy. A narrative review

2021 ◽  
Vol 2 ◽  
pp. 100010
Author(s):  
Aikaterini Theodorou ◽  
Ioanna Tsantzali ◽  
Elisabeth Kapaki ◽  
Vasilios C. Constantinides ◽  
Konstantinos Voumvourakis ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Apolipoprotein E ◽  
Cerebral Amyloid Angiopathy ◽  
Narrative Review ◽  
Amyloid Angiopathy ◽  
Cerebrospinal Fluid Biomarkers ◽  
Cerebral Amyloid ◽  
Apolipoprotein E Genotype

Machine Learning for the Prediction of Amyloid Positivity in Amnestic Mild Cognitive Impairment

2021 ◽  
pp. 1-15
Author(s):  
Sung Hoon Kang ◽  
Bo Kyoung Cheon ◽  
Ji-Sun Kim ◽  
Hyemin Jang ◽  
Hee Jin Kim ◽  
...  
Keyword(s):  
Machine Learning ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Apolipoprotein E ◽  
Cross Validation ◽  
Good Accuracy ◽  
External Validation ◽  
Amnestic Mild Cognitive Impairment ◽  
Temporal Region ◽  
Apolipoprotein E Genotype

Background: Amyloid (Aβ) evaluation in amnestic mild cognitive impairment (aMCI) patients is important for predicting conversion to Alzheimer’s disease. However, Aβ evaluation through amyloid positron emission tomography (PET) is limited due to high cost and safety issues. Objective: We therefore aimed to develop and validate prediction models of Aβ positivity for aMCI using optimal interpretable machine learning (ML) approaches utilizing multimodal markers. Methods: We recruited 529 aMCI patients from multiple centers who underwent Aβ PET. We trained ML algorithms using a training cohort (324 aMCI from Samsung medical center) with two-phase modelling: model 1 included age, gender, education, diabetes, hypertension, apolipoprotein E genotype, and neuropsychological test scores; model 2 included the same variables as model 1 with additional MRI features. We used four-fold cross-validation during the modelling and evaluated the models on an external validation cohort (187 aMCI from the other centers). Results: Model 1 showed good accuracy (area under the receiver operating characteristic curve [AUROC] 0.837) in cross-validation, and fair accuracy (AUROC 0.765) in external validation. Model 2 led to improvement in the prediction performance with good accuracy (AUROC 0.892) in cross validation compared to model 1. Apolipoprotein E genotype, delayed recall task scores, and interaction between cortical thickness in the temporal region and hippocampal volume were the most important predictors of Aβ positivity. Conclusion: Our results suggest that ML models are effective in predicting Aβ positivity at the individual level and could help the biomarker-guided diagnosis of prodromal AD.

scholarly journals Data from Digital Health Devices Informs Ideal Cardiovascular Health

2021 ◽  
Vol 11 (3) ◽  
pp. 189
Author(s):  
Jane A. Leopold ◽  
Roger B. Davis ◽  
Elliott M. Antman
Keyword(s):  
Cardiovascular Health ◽  
Digital Health ◽  
Vigorous Exercise ◽  
Activity Data ◽  
Health Score ◽  
Ideal Cardiovascular Health ◽  
Digital Devices ◽  
Significant Difference ◽  
Life’S Simple 7 ◽  
Life's Simple 7

Ideal cardiovascular health is associated with a decrease in adverse cardiovascular events. The My Research Legacy study examined ideal cardiovascular health using the Life’s Simple 7 survey and data from digital health devices. We hypothesized that digital devices provide a more objective view of overall cardiovascular health status than self-reported measures. Therefore, we analyzed weight and activity data recorded by digital devices to recalculate the Life’s Simple 7 Health Score. All study participants (n = 1561) answered the survey, while a subgroup (n = 390) provided data from digital devices. Individuals with digital devices had a lower body mass index (BMI) and higher weekly minutes of vigorous exercise than participants without digital devices (p < 0.01). Baseline Health Scores were higher in individuals with digital devices compared to those without (7.0 ± 1.6 vs. 6.6 ± 1.6, p < 0.01). Data from digital devices reveal both increases and decreases in measured vs. self-reported BMI (p < 0.04) and weekly minutes of moderate and vigorous exercise activity (p < 0.01). Using these data, a significant difference was found between the recalculated and the self-reported Life’s Simple 7 Health Score (p < 0.05). These findings suggest that incorporation of digital health devices should be considered as part of a precision medicinal approach to assessing ideal cardiovascular health.

scholarly journals Interaction between apolipoprotein E genotype and hypertension on cognitive function in older women in the Nurses’ Health Study

PLoS ONE ◽  
2019 ◽  
Vol 14 (11) ◽  
pp. e0224975 ◽  
Author(s):  
Iris Y. Kim ◽  
Francine Grodstein ◽  
Peter Kraft ◽  
Gary C. Curhan ◽  
Katherine C. Hughes ◽  
...  
Keyword(s):  
Cognitive Function ◽  
Apolipoprotein E ◽  
Older Women ◽  
Health Study ◽  
Apolipoprotein E Genotype

Association of apolipoprotein E genotype with brain levels of apolipoprotein E and apolipoprotein J (clusterin) in Alzheimer disease

1995 ◽  
Vol 33 (1) ◽  
pp. 174-178 ◽  
Author(s):  
Philippe Bertrand ◽  
Judes Poirier ◽  
Tomiichiro Oda ◽  
Caleb E. Finch ◽  
Giulio Maria Pasinetti
Keyword(s):  
Alzheimer Disease ◽  
Apolipoprotein E ◽  
Brain Levels ◽  
Apolipoprotein J ◽  
Apolipoprotein E Genotype

Effects of apolipoprotein E genotype on lipid profile and changes in lipid profile during hormone therapy in postmenopausal Korean women

Maturitas ◽  
2017 ◽  
Vol 100 ◽  
pp. 150
Author(s):  
Sung-Eun Kim ◽  
Jong-Wook Seo ◽  
Dong-Yun Lee ◽  
Byung-Koo Yoon ◽  
Seok Hyun Kim
Keyword(s):  
Apolipoprotein E ◽  
Hormone Therapy ◽  
Lipid Profile ◽  
Korean Women ◽  
Apolipoprotein E Genotype

scholarly journals Apolipoprotein E genotype status affects habitual human blood mononuclear cell gene expression and its response to fish oil intervention

2016 ◽  
Vol 60 (7) ◽  
pp. 1649-1660 ◽  
Author(s):  
Juri C. Matualatupauw ◽  
Marijana Radonjic ◽  
Ondine van de Rest ◽  
Lisette C. P. G. M. de Groot ◽  
Johanna M. Geleijnse ◽  
...  
Keyword(s):  
Gene Expression ◽  
Fish Oil ◽  
Apolipoprotein E ◽  
Mononuclear Cell ◽  
Human Blood ◽  
Cell Gene Expression ◽  
Cell Gene ◽  
Apolipoprotein E Genotype

Apolipoprotein E genotype and amyloid load in Alzheimer disease and control brains

1997 ◽  
Vol 18 (1) ◽  
pp. 121-127 ◽  
Author(s):  
T. Pirttilä ◽  
H. Soininen ◽  
P.D. Mehta ◽  
O. Heinonen ◽  
T. Lehtimäki ◽  
...  
Keyword(s):  
Alzheimer Disease ◽  
Apolipoprotein E ◽  
Amyloid Load ◽  
And Control ◽  
Apolipoprotein E Genotype
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