scholarly journals Examination of cognitive performance and mild behavioral impairment domains of apathy, mood, impulse dyscontrol, social inappropriateness and psychosis in cognitively normal adults aged 50 and over

2021 ◽  
Vol 17 (S6) ◽  
Author(s):  
Nianqi Sun ◽  
Zahinoor Ismail ◽  
Dag Aarsland ◽  
Helen Brooker ◽  
Anne Corbett ◽  
...  
Keyword(s):  
Cognitive Performance ◽  
Behavioral Impairment ◽  
Cognitively Normal ◽  
Normal Adults

scholarly journals Cortical amyloid burden and age moderate hippocampal activity in cognitively-normal adults

2016 ◽  
Vol 12 ◽  
pp. 78-84 ◽  
Author(s):  
Zhuang Song ◽  
Ian M. McDonough ◽  
Peiying Liu ◽  
Hanzhang Lu ◽  
Denise C. Park
Keyword(s):  
Amyloid Burden ◽  
Cognitively Normal ◽  
Hippocampal Activity ◽  
Normal Adults

Evaluation of Motor and Cognitive Performance in People with Parkinson’s Disease Using Instrumented Trail-Making Test

Gerontology ◽  
2021 ◽  
pp. 1-7
Author(s):  
Ram kinker Mishra ◽  
Catherine Park ◽  
He Zhou ◽  
Bijan Najafi ◽  
T. Adam Thrasher
Keyword(s):  
Older Adults ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cognitive Performance ◽  
Pairwise Comparison ◽  
Walking Test ◽  
Cognitively Normal ◽  
Early Results ◽  
Trail Making ◽  
Changes Over Time

<b><i>Introduction:</i></b> Parkinson’s disease (PD) progressively impairs motor and cognitive performance. The current tools to detect decline in motor and cognitive functioning are often impractical for busy clinics and home settings. To address the gap, we designed an instrumented trail-making task (iTMT) based on a wearable sensor (worn on the shin) with interactive game-based software installed on a tablet. The iTMT test includes reaching to 5 indexed circles, a combination of numbers (1–3) and letters (A&amp;B) randomly positioned inside target circles, in a sequential order, which virtually appears on a screen kept in front of the participants, by rotating one’s ankle joint while standing and holding a chair for safety. By measuring time to complete iTMT task (iTMT time), iTMT enables quantifying cognitive-motor performance. <b><i>Purpose:</i></b> This study’s objective is to examine the feasibility of iTMT to detect early cognitive-motor decline in PDs. <b><i>Method:</i></b> Three groups of volunteers, including 14 cognitively normal (CN) older adults, 14 PDs, and 11 mild cognitive impaireds (MCI), were recruited. Participants completed MoCA, 20 m walking test, and 3 trials of iTMT. <b><i>Results:</i></b> All participants enabled to complete iTMT with &#x3c;3 min, indicating high feasibility. The average iTMT time for CN-Older, PD, and MCI participants were 20.9 ± 0.9 s, 32.3 ± 2.4 s, and 40.9 ± 4.5 s, respectively. After adjusting for age and education level, pairwise comparison suggested large effect sizes for iTMT between CN-older versus PD (Cohen’s <i>d</i> = 1.7, <i>p</i> = 0.024) and CN-older versus MCI (<i>d</i> = 1.57, <i>p</i> &#x3c; 0.01). Significant correlations were observed when comparing iTMT time with the gait speed (<i>r</i> = −0.4, <i>p</i> = 0.011) and MoCA score (<i>r</i> = −0.56, <i>p</i> &#x3c; 0.01). <b><i>Conclusion:</i></b> This study demonstrated the feasibility and early results supporting the potential application of iTMT to determine cognitive-motor and distinguishing individuals with MCI and PD from CN-older adults. Future studies are warranted to test the ability of iTMT to track its subtle changes over time.

scholarly journals Depression is Associated with Tau and Not Amyloid Positron Emission Tomography in Cognitively Normal Adults

2020 ◽  
Vol 74 (4) ◽  
pp. 1045-1055
Author(s):  
Ganesh M. Babulal ◽  
Catherine M. Roe ◽  
Sarah H. Stout ◽  
Ganesh Rajasekar ◽  
Julie K. Wisch ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Emission Tomography ◽  
Amyloid Positron Emission Tomography ◽  
Cognitively Normal ◽  
Positron Emission ◽  
Normal Adults

P2-134: Age and apolipoprotein E*4 effects on cerebrospinal fluid Aβ42 in cognitively normal adults

2006 ◽  
Vol 2 ◽  
pp. S273-S273
Author(s):  
Elaine R. Peskind ◽  
Gail Li ◽  
Jane Shofer ◽  
Joseph Quinn ◽  
Jeffrey Kaye ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Apolipoprotein E ◽  
Cognitively Normal ◽  
Normal Adults

Association of Plasma Neurofilament Light Chain with Neocortical Amyloid-β Load and Cognitive Performance in Cognitively Normal Elderly Participants

2018 ◽  
Vol 63 (2) ◽  
pp. 479-487 ◽  
Author(s):  
Pratishtha Chatterjee ◽  
Kathryn Goozee ◽  
Hamid R. Sohrabi ◽  
Kaikai Shen ◽  
Tejal Shah ◽  
...  
Keyword(s):  
Cognitive Performance ◽  
Light Chain ◽  
Amyloid Β ◽  
Neurofilament Light Chain ◽  
Neurofilament Light ◽  
Cognitively Normal

P1-302: ASSOCIATION OF PLASMA NEUROFILAMENT LIGHT CHAIN WITH COGNITIVE PERFORMANCE IN COGNITIVELY NORMAL ELDERLY PARTICIPANTS

2006 ◽  
Vol 14 (7S_Part_7) ◽  
pp. P405-P406
Author(s):  
Pratishtha Chatterjee ◽  
Kathryn Goozee ◽  
Hamid R. Sohrabi ◽  
Kaikai Shen ◽  
Tejal M. Shah ◽  
...  
Keyword(s):  
Cognitive Performance ◽  
Light Chain ◽  
Neurofilament Light Chain ◽  
Neurofilament Light ◽  
Cognitively Normal

P4-061: Reduced Hippocampal Activity During Encoding in Cognitively Normal Adults Carrying the Apoe ε4 Allele

2010 ◽  
Vol 6 ◽  
pp. e39-e39
Author(s):  
Maheen Mausoof Adamson ◽  
Benjamin Hutchinson ◽  
Amy Shelton ◽  
Anthony Wagner ◽  
Joy L. Taylor
Keyword(s):  
Cognitively Normal ◽  
Apoe Ε4 ◽  
Hippocampal Activity ◽  
Ε4 Allele ◽  
Normal Adults
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