scholarly journals Predictive factors for conversion to dementia in individuals with early‐onset mild cognitive impairment

2021 ◽  
Vol 17 (S6) ◽  
Author(s):  
Kate Baird ◽  
Sarah Baillon ◽  
Lilian Lau ◽  
Mathew Storey ◽  
James Lindesay ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Predictive Factors ◽  
Early Onset

scholarly journals Predictive Factors for Conversion to Dementia in Individuals with Early-Onset Mild Cognitive Impairment

2021 ◽  
pp. 1-6
Author(s):  
Kate Baird ◽  
Sarah Baillon ◽  
Lilian Suh Lih Lau ◽  
Mathew Storey ◽  
James Lindesay ◽  
...  
Keyword(s):  
Survival Analysis ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Predictive Factors ◽  
Early Onset ◽  
Cox Regression ◽  
University Teaching ◽  
Smoking History ◽  
Remote Memory ◽  
Cutoff Score

<b><i>Introduction:</i></b> There is little research on factors predicting conversion to dementia in early-onset mild cognitive impairment (eoMCI), a transitional stage between healthy ageing and dementia in individuals below the age of 65. We aimed to examine whether sociodemographic and clinical factors at initial presentation predicted dementia progression in a cohort of eoMCI patients attending a memory service, at a university teaching hospital in the UK. <b><i>Methods:</i></b> This is a retrospective case note study of individuals diagnosed with eoMCI between 2000 and 2013 at the Younger Person’s Memory Service (YPMS) in Leicestershire, England. Data collected at assessment included social factors, demographic characteristics, and medical and psychiatric history, as well as standardized cognitive assessment scores. Variables were analysed using χ<sup>2</sup> or independent sample <i>t</i> tests to identify associations. A Cox regression survival analysis was done to identify predictive factors for dementia conversion. An ROC analysis for total CAMCOG was used to investigate sensitivity and specificity for dementia converters versus non-converters. <b><i>Results:</i></b> Out of 531 subjects who attended YPMS, 65 patients were given a diagnosis of eoMCI (47.7% female; mean age 56.4 ± 7.54 years). Of these, 21 (32.3%) converted to dementia during their course within the service. Comparison between subgroups revealed a significant association between dementia conversion and higher years of education and lower MMSE and CAMCOG (total and subscale) scores at baseline. Smoking history, alcohol use, or medical history such as diabetes or heart disease were not associated with conversion. Cox regression survival analysis showed higher education in years and lower total CAMCOG scores were significant predictors for conversion. Lower scores on the recent memory, remote memory, learning memory, and executive function subscales of the CAMCOG were also significant predictors for conversion. ROC curve analysis for total CAMCOG demonstrated that the best detection of dementia converters can be achieved with a cutoff score of 90.5/107 (sensitivity of 76.2% and specificity of 68.2%). Area under the curve was 0.808 (95% CI: 0.697–0.920). <b><i>Conclusion:</i></b> More years in education and lower cognitive scores on CAMCOG at initial assessment are associated with progression to dementia from eoMCI. Further research is required to explore these predictive factors more.

scholarly journals Prognosis of Early-Onset vs. Late-Onset Mild Cognitive Impairment: Comparison of Conversion Rates and Its Predictors

Geriatrics ◽  
2016 ◽  
Vol 1 (2) ◽  
pp. 11 ◽  
Author(s):  
Miguel Tábuas-Pereira ◽  
Inês Baldeiras ◽  
Diana Duro ◽  
Beatriz Santiago ◽  
Maria Ribeiro ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Early Onset ◽  
Late Onset ◽  
Conversion Rates

scholarly journals Sleep Disturbances and Predictive Factors in Caregivers of Patients with Mild Cognitive Impairment and Dementia

2014 ◽  
Vol 10 (4) ◽  
pp. 304 ◽  
Author(s):  
Dongwhane Lee ◽  
Sung Hyuk Heo ◽  
Sung-Sang Yoon ◽  
Dae-Il Chang ◽  
Sangeui Lee ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Predictive Factors ◽  
Sleep Disturbances

[P1-338]: SMELL IDENTIFICATION IMPAIRMENT IN EARLY ONSET ALZHEIMER's DIASEASE AND MILD COGNITIVE IMPAIRMENT

2017 ◽  
Vol 13 (7S_Part_8) ◽  
pp. P385-P386
Author(s):  
Latha Velayudhan ◽  
Frances Morkeh-Wilson ◽  
Emily Penny ◽  
Amy Gasper ◽  
Terry Brugha ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Early Onset ◽  
Smell Identification

scholarly journals Excessive Seizure Clusters in an Otherwise Well-Controlled Epilepsy as a Possible Hallmark of Untreated Vitamin B6-Responsive Epilepsy due to a Homozygous PLPBP Missense Variant

2019 ◽  
Vol 08 (04) ◽  
pp. 222-225
Author(s):  
Jessika Johannsen ◽  
Tatjana Bierhals ◽  
Philipp Deindl ◽  
Laura Hecher ◽  
Katharina Hermann ◽  
...  
Keyword(s):  
Learning Disabilities ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Early Onset ◽  
Vitamin B6 ◽  
Seizure Control ◽  
Missense Variant ◽  
Male Adolescent ◽  
Anxiety States ◽  
Good Seizure Control

AbstractRecently, mutations in the PLPBP gene were described as a novel cause for vitamin B6-responsive epilepsy. We report the outcome in case of a male adolescent with a novel homozygous missense variant in PLPBP who was never treated with pyridoxine until the age of 16 years. He presented with only mild cognitive impairment and an early-onset, well-controlled epilepsy. In our patient, excessive seizure clusters and anxiety states occurred intermittently, suggesting that the combination might be a hallmark in untreated patients. Thus, mutations in PLPBP should be addressed even in adolescent patients with only mild learning disabilities and relatively good seizure control over the years.

scholarly journals BIOFACE: A prospective study of risk factors, cognition and biomarkers in a cohort of individuals with early‐onset mild cognitive impairment at Fundació ACE

2021 ◽  
Vol 17 (S5) ◽  
Author(s):  
Ester Esteban‐De Antonio ◽  
Alba Pérez‐Cordón ◽  
Silvia Gil ◽  
Amanda Cano ◽  
Adelina Orellana ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Prospective Study ◽  
Early Onset ◽  
A Prospective Study

scholarly journals Fluid intelligence and its neural correlates in early onset mild cognitive impairment

2021 ◽  
Vol 17 (S6) ◽  
Author(s):  
Chiara Carbone ◽  
Elisa Bardi ◽  
Maria Giulia Corni ◽  
Luigi Fiondella ◽  
Simone Salemme ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Early Onset ◽  
Fluid Intelligence ◽  
Neural Correlates
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