scholarly journals Oxidative stress biomarkers in individuals with Down syndrome: Implications to the pathogeny of Alzheimer's disease

2021 ◽  
Vol 17 (S5) ◽  
Author(s):  
Gabriella Ayub de Mendonça ◽  
Orestes Vicente Forlenza
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Down Syndrome ◽  
Oxidative Stress Biomarkers ◽  
Stress Biomarkers

Peripheral Oxidative Stress Biomarkers in Mild Cognitive Impairment and Alzheimer's Disease

2011 ◽  
Vol 26 (1) ◽  
pp. 59-68 ◽  
Author(s):  
Larissa Lobo Torres ◽  
Nathalia Barbosa Quaglio ◽  
Gisele Tavares de Souza ◽  
Raphael Tamborelli Garcia ◽  
Lívia Mendonça Munhoz Dati ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Impairment ◽  
Mild Cognitive Impairment ◽  
Oxidative Stress Biomarkers ◽  
Stress Biomarkers

The Study of Homocysteine and Its Relationship with Oxidative Stress Biomarkers in Alzheimer’s Disease

2016 ◽  
Author(s):  
Ms. Santoshi R. Ghodake ◽  
◽  
Dr. Adinath N. Suryakar ◽  
Dr. Prabhakar M. Kulhalli ◽  
Dr Abdul Kayyum Shaikh ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Oxidative Stress Biomarkers ◽  
Stress Biomarkers

Lactobacilli and bifidobacteria ameliorate memory and learning deficits and oxidative stress in β-amyloid (1–42) injected rats

2018 ◽  
Vol 43 (7) ◽  
pp. 718-726 ◽  
Author(s):  
Somayeh Athari Nik Azm ◽  
Abolghassem Djazayeri ◽  
Majid Safa ◽  
Kian Azami ◽  
Behzad Ahmadvand ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Morris Water Maze ◽  
Water Maze ◽  
Oxidative Stress Biomarkers ◽  
Memory And Learning ◽  
Stress Biomarkers ◽  
Intrahippocampal Injection ◽  
Β Amyloid ◽  
And Oxidative Stress

The gastrointestinal microbiota affects brain function, including memory and learning. In this study we investigated the effects of probiotics on memory and oxidative stress biomarkers in an experimental model of Alzheimer’s disease. Sixty rats were randomly divided into 5 groups: control; control-probiotics, which received probiotics for 8 weeks; sham operation, which received an intrahippocampal injection of phosphate-buffered saline; Alzheimer, which received an intrahippocampal injection of β-amyloid (Aβ1–42); and Alzheimer-probiotics, which in addition to being injected with Aβ1–42, received 2 g (1 × 1010 CFU/g) of probiotics (Lactobacillus acidophilus, L. fermentum, Bifidobacterium lactis, and B. longum) for 8 weeks. Memory and learning were measured using the Morris water maze, and oxidative stress biomarkers in the hippocampus were measured using ELISA kits. Morris water maze results indicated that compared with the Alzheimer group, the Alzheimer-probiotics group had significantly improved spatial memory, including shorter escape latency and travelled distance and greater time spent in the target quadrant. There was also improvement in oxidative stress biomarkers such as increased malondialdehyde levels and superoxide dismutase activity following the β-amyloid injection. Overall, it seems that probiotics play a role in improving memory deficit and inhibiting the pathological mechanisms of Alzheimer’s disease by modifying microbiota.

Fruitless Wolfberry-Sprout Extract Rescued Cognitive Deficits and Attenuated Neuropathology in Alzheimer’s Disease Transgenic Mice

2018 ◽  
Vol 15 (9) ◽  
pp. 856-868 ◽  
Author(s):  
Shu-Ying Liu ◽  
Shuai Lu ◽  
Xiao-Lin Yu ◽  
Shi-Gao Yang ◽  
Wen Liu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Oral Administration ◽  
Inflammatory Cytokines ◽  
Therapeutic Potential ◽  
Dot Blot ◽  
Oxidative Stress Biomarkers ◽  
Object Recognition Test ◽  
Aβ Oligomer

Background: Alzheimer’s disease (AD) is a neurodegenerative disease featured by memory loss, neuroinflammation and oxidative stress. Overproduction or insufficient clearance of Aβ leads to its pathological aggregation and deposition, which is considered the predominant neuropathological hallmark of AD. Therefore, reducing Aβ levels and inhibiting Aβ-induced neurotoxicity are feasible therapeutic strategies for AD treatment. Wolfberry has been traditionally used as a natural antioxidant and anti-aging product. However, whether wolfberry species has therapeutic potential on AD remains unknown. Method: The effects of fruitless wolfberry-sprout extract (FWE) on Aβ fibrillation and fibril disaggregation was measured by thioflavin T fluorescence and transmission electron microscope imaging; Aβ oligomer level was determined by dot-blot; Cell viability and apoptosis was assessed by MTT and TUNEL assay. The levels of Aβ40/42, oxidative stress biomarkers and inflammatory cytokines were detected by corresponding kits. 8-month-old male APP/PS1 mice and their age-matched WT littermates were treated with FWE or vehicle by oral administration (gavage) once a day for 4 weeks. Then the cognitive performance was determined using object recognition test and Y-maze test. The Aβ burden and gliosis was evaluated by immunostaining and immunoblotting, respectively. Results: FWE significantly inhibited Aβ fibrillation and disaggregated the formed Aβ fibrils, lowered Aβ oligomer level and Aβ-induced neuro-cytotoxicity, and attenuated oxidative stress in vitro. Oral administration of FWE remarkably improved cognitive function, reduced Aβ burden, decreased gliosis and inflammatory cytokines release, and ameliorated oxidative stress in the brains of APP/PS1 mice. Conclusion: These findings indicate that FWE is a promising natural agent for AD treatment.

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