scholarly journals Cannabinoid agonist WIN 55,212‐2 improves memory consolidation in a rat model of basal forebrain cholinergic lesion

2021 ◽  
Vol 17 (S9) ◽  
Author(s):  
Iker Bengoetxea de Tena ◽  
Jonatan Martínez‐Gardeazabal ◽  
Marta Moreno‐Rodríguez ◽  
Gorka Pereira‐Castelo ◽  
Iván Manuel ◽  
...  
Keyword(s):  
Rat Model ◽  
Memory Consolidation ◽  
Basal Forebrain ◽  
Cannabinoid Agonist

scholarly journals Inhibitory Effects of Edaravone inβ-Amyloid-Induced Neurotoxicity in Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Feng He ◽  
Yan-Ping Cao ◽  
Feng-Yuan Che ◽  
Lian-Hong Yang ◽  
Song-Hua Xiao ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Rat Model ◽  
Basal Forebrain ◽  
Neuroprotective Effect ◽  
Memory Performance ◽  
Cholinergic Neurons ◽  
Free Radical Scavenger ◽  
Radical Scavenger ◽  
Dependent Manner ◽  
Induced Voltage

Amyloid protein can damage nerve cells through a variety of biological mechanisms including oxidative stress, alterations in calcium homeostasis, and proapoptosis. Edaravone, a potent free radical scavenger possessing antioxidant effects, has been proved neuroprotective effect in stroke patients. The current study aimed to investigate the effects of EDA in an Aβ-induced rat model of AD, by studying Aβ1–40-induced voltage-gated calcium channel currents in hippocampal CA1 pyramidal neurons, learning and memory behavioral tests, the number of surviving cholinergic neurons in the basal forebrain, and the acetylcholine level in the hippocampus in this rat model of AD. The results showed that the Aβ1–40-induced increase ofICacan be inhibited by EDA in a dose-dependent manner. Treatment with EDA significantly improved Aβ1–40-induced learning and memory performance. Choline acetyltransferase positive cells in basal forebrain and acetylcholine content in the hippocampus were increased by the administration of EDA as compared with the non-EDA treated Aβ1–40group. These results demonstrate that EDA can inhibit the neurotoxic effect of Aβtoxicity. Collectively, these findings suggest that EDA may serve as a potential complemental treatment strategy for AD.

scholarly journals Icariin Promotes Survival, Proliferation, and Differentiation of Neural Stem Cells In Vitro and in a Rat Model of Alzheimer’s Disease

2021 ◽  
Vol 2021 ◽  
pp. 1-12
Author(s):  
Denglei Ma ◽  
Lihong Zhao ◽  
Li Zhang ◽  
Yali Li ◽  
Lan Zhang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Rat Model ◽  
Basal Forebrain ◽  
Chinese Herb ◽  
Cholinergic Neurons ◽  
Model Of Alzheimer’S Disease ◽  
Promising Therapeutic Approach ◽  
Proliferation And Differentiation

Alzheimer’s disease (AD) involves the degeneration of cholinergic neurons in the basal forebrain. Neural stem cell (NSC) transplantation has emerged as a promising therapeutic approach for treating AD. Icariin (ICA) is the main active component in Epimedium, a traditional Chinese herb. The purpose of the present study was to investigate the effects and mechanisms of ICA on the proliferation and differentiation of NSCs in the basal forebrain of a fimbria-fornix transection (FFT) rat model. In the present study, ICA promoted the survival, proliferation, and migration of NSCs in vitro. In FFT rats, ICA promoted the proliferation and differentiation of NSCs into neurons and increased the number of cholinergic neurons in the MS and VDB of the basal forebrain. These results suggest that combination therapy of ICA oral administration and NSC transplantation may provide a new potential and effective approach for AD therapy.

Chronic Lithium Treatment in a Rat Model of Basal Forebrain Cholinergic Depletion: Effects on Memory Impairment and Neurodegeneration

2017 ◽  
Vol 56 (4) ◽  
pp. 1505-1518 ◽  
Author(s):  
Francesca Gelfo ◽  
Debora Cutuli ◽  
Annalisa Nobili ◽  
Paola De Bartolo ◽  
Marcello D’Amelio ◽  
...  
Keyword(s):  
Rat Model ◽  
Basal Forebrain ◽  
Memory Impairment ◽  
Lithium Treatment

Increase in cortical endocannabinoid signaling in a rat model of basal forebrain cholinergic dysfunction

Neuroscience ◽  
2017 ◽  
Vol 362 ◽  
pp. 206-218 ◽  
Author(s):  
Alberto Llorente-Ovejero ◽  
Iván Manuel ◽  
Maria Teresa Giralt ◽  
Rafael Rodríguez-Puertas
Keyword(s):  
Rat Model ◽  
Basal Forebrain ◽  
Cholinergic Dysfunction

Cortical Metabolic Deficits in a Rat Model of Cholinergic Basal Forebrain Degeneration

2013 ◽  
Vol 38 (10) ◽  
pp. 2114-2123 ◽  
Author(s):  
Francesca Gelfo ◽  
Laura Petrosini ◽  
Alessandro Graziano ◽  
Paola De Bartolo ◽  
Lorena Burello ◽  
...  
Keyword(s):  
Rat Model ◽  
Basal Forebrain ◽  
Cholinergic Basal Forebrain
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