scholarly journals Cerebrospinal fluid and saliva lactoferrin as a diagnostic biomarker for Alzheimer’s disease in a mixed memory clinic population

2021 ◽  
Vol 17 (S5) ◽  
Author(s):  
Helena Sophia Gleerup ◽  
Camilla Steen Jensen ◽  
Peter Høgh ◽  
Steen Gregers Hasselbalch ◽  
Anja Hviid Simonsen
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Diagnostic Biomarker ◽  
Memory Clinic ◽  
Clinic Population

scholarly journals Lactoferrin in cerebrospinal fluid and saliva is not a diagnostic biomarker for Alzheimer's disease in a mixed memory clinic population

EBioMedicine ◽  
2021 ◽  
Vol 67 ◽  
pp. 103361
Author(s):  
Helena Sophia Gleerup ◽  
Camilla Steen Jensen ◽  
Peter Høgh ◽  
Steen Gregers Hasselbalch ◽  
Anja Hviid Simonsen
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Diagnostic Biomarker ◽  
Memory Clinic ◽  
Clinic Population

P1-371: New research criteria for the diagnosis of Alzheimer's disease applied in a memory clinic population

2008 ◽  
Vol 4 ◽  
pp. T327-T328 ◽  
Author(s):  
Femke H. Bouwman ◽  
Nicolaas A. Verwey ◽  
Martin Klein ◽  
Yolande A.L. Pijnenburg ◽  
Astrid Kok ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Memory Clinic ◽  
New Research ◽  
Research Criteria ◽  
Clinic Population

Neuropsychological performance in Alzheimer's disease and vascular dementia: comparisons in a memory clinic population

2003 ◽  
Vol 18 (7) ◽  
pp. 602-608 ◽  
Author(s):  
Sarah Baillon ◽  
Saquib Muhommad ◽  
Mangesh Marudkar ◽  
Srinivas Suribhatla ◽  
Michael Dennis ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Vascular Dementia ◽  
Neuropsychological Performance ◽  
Memory Clinic ◽  
Clinic Population

scholarly journals Amyloidogenic Nanoplaques in Cerebrospinal Fluid: Relationship to Amyloid Brain Uptake and Clinical Alzheimer’s Disease in a Memory Clinic Cohort

2020 ◽  
Vol 77 (2) ◽  
pp. 831-842 ◽  
Author(s):  
Mari Aksnes ◽  
Ebba Glersen Müller ◽  
Ann Tiiman ◽  
Trine Holt Edwin ◽  
Lars Terenius ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Apoe Genotype ◽  
Amyloid Β ◽  
Correlation Spectroscopy ◽  
Brain Uptake ◽  
Memory Clinic ◽  
Fluorescence Correlation ◽  
Pathological Event

Background: Aggregation of amyloid-β (Aβ) is an early pathological event in Alzheimer’s disease (AD). Consequently, measures of pathogenic aggregated Aβ are attractive biomarkers for AD. Here, we use a recently developed Thioflavin-T-Fluorescence Correlation Spectroscopy (ThT-FCS) assay to quantify structured ThT-responsive protein aggregates, so-called nanoplaques, in the cerebrospinal fluid (CSF). Objective: The overall aim of this work was to assess whether ThT-FCS determined CSF nanoplaque levels could predict amyloid brain uptake as determined by 18F-Flutemetamol PET analysis. Further, we assess whether nanoplaque levels could predict clinical AD. Methods: Nanoplaque levels in the CSF from 54 memory clinic patients were compared between sub-groups classified by 18F-Flutemetamol PET as amyloid-positive or amyloid-negative, and by clinical assessment as AD or non-AD. Results: Nanoplaque levels did not differ between amyloid groups and could not predict brain amyloid uptake. However, nanoplaque levels were significantly increased in patients with clinical AD, and were significant predictors for AD when adjusting for age, sex, cognitive function, and apolipoprotein E (APOE) genotype. Conclusion: The concentration of nanoplaques in the CSF differentiates patients with clinical AD from non-AD patients.

scholarly journals Practical use of visual medial temporal lobe atrophy cut-off scores in Alzheimer’s disease: Validation in a large memory clinic population

2017 ◽  
Vol 27 (8) ◽  
pp. 3147-3155 ◽  
Author(s):  
Jules J. Claus ◽  
Salka S. Staekenborg ◽  
Dana C. Holl ◽  
Jelmen J. Roorda ◽  
Jacqueline Schuur ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Memory Clinic ◽  
Medial Temporal Lobe Atrophy ◽  
Large Memory ◽  
Clinic Population ◽  
Lobe Atrophy
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