scholarly journals Longitudinal assessment of neuroinflammation and axonal loss in white matter tracts in Alzheimer’s disease

2020 ◽  
Vol 16 (S5) ◽  
Author(s):  
Maggie Roy ◽  
Matthieu Dumont ◽  
Jean‐Christophe Houde ◽  
Félix Morency ◽  
Maxime Descoteaux
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Axonal Loss ◽  
Longitudinal Assessment ◽  
White Matter Tracts

scholarly journals Frontal white matter lesions in Alzheimer’s disease are associated with both small vessel disease and AD-associated cortical pathology

2021 ◽  
Author(s):  
Kirsty E. McAleese ◽  
Mohi Miah ◽  
Sophie Graham ◽  
Georgina M. Hadfield ◽  
Lauren Walker ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Regional Differences ◽  
Small Vessel Disease ◽  
White Matter Lesions ◽  
Small Vessel ◽  
Published Data ◽  
Axonal Loss ◽  
Vessel Disease

AbstractCerebral white matter lesions (WML) encompass axonal loss and demyelination and are assumed to be associated with small vessel disease (SVD)-related ischaemia. However, our previous study in the parietal lobe white matter revealed that WML in Alzheimer’s disease (AD) are linked with degenerative axonal loss secondary to the deposition of cortical AD pathology. Furthermore, neuroimaging data suggest that pathomechanisms for the development of WML differ between anterior and posterior lobes with AD-associated degenerative mechanism driving posterior white matter disruption, and both AD-associated degenerative and vascular mechanisms contributed to anterior matter disruption. In this pilot study, we used human post-mortem brain tissue to investigate the composition and aetiology of frontal WML from AD and non-demented controls to determine if frontal WML are SVD-associated and to reveal any regional differences in the pathogenesis of WML. Frontal WML tissue sections from 40 human post-mortem brains (AD, n = 19; controls, n = 21) were quantitatively assessed for demyelination, axonal loss, cortical hyperphosphorylated tau (HPτ) and amyloid-beta (Aβ) burden, and arteriolosclerosis as a measure of SVD. Biochemical assessment included Wallerian degeneration-associated protease calpain and the myelin-associated glycoprotein to proteolipid protein ratio as a measure of ante-mortem ischaemia. Arteriolosclerosis severity was found to be associated with and a significant predictor of frontal WML severity in both AD and non-demented controls. Interesting, frontal axonal loss was also associated with HPτ and calpain levels were associated with increasing Aβ burden in the AD group, suggestive of an additional degenerative influence. To conclude, this pilot data suggest that frontal WML in AD may result from both increased arteriolosclerosis and AD-associated degenerative changes. These preliminary findings in combination with previously published data tentatively indicate regional differences in the aetiology of WML in AD, which should be considered in the clinical diagnosis of dementia subtypes: posterior WML maybe associated with degenerative mechanisms secondary to AD pathology, while anterior WML could be associated with both SVD-associated and degenerative mechanisms.

IC-P-108: Apparent fibre density: A novel MRI approach that identifies specific white matter tracts affected in Alzheimer's disease and MCI

2012 ◽  
Vol 8 (4S_Part_2) ◽  
pp. P61-P61
Author(s):  
David Raffelt ◽  
J. Donald Tournier ◽  
Stuart Crozier ◽  
Kathryn Ellis ◽  
Ralph Martins ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
White Matter Tracts ◽  
Fibre Density

scholarly journals Surface-Based Analysis on Shape and Fractional Anisotropy of White Matter Tracts in Alzheimer's Disease

PLoS ONE ◽  
2010 ◽  
Vol 5 (3) ◽  
pp. e9811 ◽  
Author(s):  
Anqi Qiu ◽  
Kenichi Oishi ◽  
Michael I. Miller ◽  
Constantine G. Lyketsos ◽  
Susumu Mori ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Fractional Anisotropy ◽  
White Matter Tracts

scholarly journals Distinctive disruption patterns of white matter tracts in Alzheimer's disease with full diffusion tensor characterization

2012 ◽  
Vol 33 (9) ◽  
pp. 2029-2045 ◽  
Author(s):  
Hao Huang ◽  
Xin Fan ◽  
Myron Weiner ◽  
Kristin Martin-Cook ◽  
Guanghua Xiao ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Diffusion Tensor ◽  
White Matter Tracts
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