Effects of omega‐3 fatty acids on cerebral white matter hyperintensities and medial temporal lobe atrophy in older non‐demented adults: A 3‐year randomized‐controlled phase 2 trial

Gene L Bowman; Lisa C Silbert; Hiroko H Dodge; Kirsten Hagen; Jason C David; Charles F Murchison; David Lahna; Jeffrey Kaye; Joseph F Quinn; Lynne Shinto

doi:10.1002/alz.046608

Effects of omega‐3 fatty acids on cerebral white matter hyperintensities and medial temporal lobe atrophy in older non‐demented adults: A 3‐year randomized‐controlled phase 2 trial

Alzheimer s & Dementia ◽

10.1002/alz.046608 ◽

2020 ◽

Vol 16 (S10) ◽

Author(s):

Gene L Bowman ◽

Lisa C Silbert ◽

Hiroko H Dodge ◽

Kirsten Hagen ◽

Jason C David ◽

...

Keyword(s):

Medial Temporal Lobe ◽

White Matter Hyperintensities ◽

Cerebral White Matter ◽

Phase 2 ◽

Omega 3 Fatty Acids ◽

Omega 3 ◽

Medial Temporal Lobe Atrophy ◽

Randomized Controlled ◽

Phase 2 Trial ◽

Lobe Atrophy

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Omega-3 PUFA for Cerebral White Matter Hyperintensities, Medial Temporal Lobe Atrophy and White Matter Integrity in Older Adults: A 3-Year Randomized-Controlled Phase 2 Trial

SSRN Electronic Journal ◽

10.2139/ssrn.3772820 ◽

2021 ◽

Author(s):

Gene L. Bowman ◽

Charles F. Murchison ◽

Lisa C. Silbert ◽

Hiroko H. Dodge ◽

Kirsten Hagen ◽

...

Keyword(s):

White Matter ◽

Medial Temporal Lobe ◽

White Matter Hyperintensities ◽

Cerebral White Matter ◽

Phase 2 ◽

Omega 3 ◽

Medial Temporal Lobe Atrophy ◽

Randomized Controlled ◽

Phase 2 Trial ◽

Lobe Atrophy

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Randomized trial of n‐3 PUFA for cerebral white matter hyperintensities, medial temporal lobe atrophy and white matter integrity in older non‐demented adults: Per‐protocol and ApoE stratified results

Alzheimer s & Dementia ◽

10.1002/alz.055682 ◽

2021 ◽

Vol 17 (S10) ◽

Author(s):

Gene L Bowman ◽

Charles F Murchison ◽

Lisa C Silbert ◽

Hiroko H Dodge ◽

Kirsten Hagen ◽

...

Keyword(s):

White Matter ◽

Randomized Trial ◽

Temporal Lobe ◽

Medial Temporal Lobe ◽

White Matter Hyperintensities ◽

White Matter Integrity ◽

Cerebral White Matter ◽

Medial Temporal Lobe Atrophy ◽

Lobe Atrophy

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P2-161: Plasma long-chain omega-3 fatty acids and medial temporal lobe atrophy: a longitudinal MRI study

Alzheimer s & Dementia ◽

10.1016/j.jalz.2011.05.1047 ◽

2011 ◽

Vol 7 ◽

pp. S363-S363

Author(s):

Cécilia Samieri ◽

Pauline Maillard ◽

Fabrice Crivello ◽

Evelyne Peuchant ◽

Catherine Helmer ◽

...

Keyword(s):

Fatty Acids ◽

Temporal Lobe ◽

Medial Temporal Lobe ◽

Omega 3 Fatty Acids ◽

Omega 3 ◽

Medial Temporal Lobe Atrophy ◽

Longitudinal Mri ◽

Mri Study ◽

Lobe Atrophy ◽

Long Chain

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Behavioural and psychological symptoms are not related to white matter hyperintensities and medial temporal lobe atrophy in Alzheimer's disease

International Journal of Geriatric Psychiatry ◽

10.1002/gps.1891 ◽

2008 ◽

Vol 23 (4) ◽

pp. 387-392 ◽

Cited By ~ 23

Author(s):

Salka S. Staekenborg ◽

Freek Gillissen ◽

Rolinka Romkes ◽

Yolande A. L. Pijnenburg ◽

Frederik Barkhof ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

White Matter ◽

Temporal Lobe ◽

Medial Temporal Lobe ◽

White Matter Hyperintensities ◽

Psychological Symptoms ◽

Medial Temporal Lobe Atrophy ◽

Behavioural And Psychological Symptoms ◽

Lobe Atrophy

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White Matter Hyperintensities, Medial Temporal Lobe Atrophy, Cortical Atrophy, and Response to Electroconvulsive Therapy in Severely Depressed Elderly Patients

The Journal of Clinical Psychiatry ◽

10.4088/jcp.08m04989blu ◽

2010 ◽

Vol 72 (01) ◽

pp. 104-112 ◽

Cited By ~ 31

Author(s):

Mardien L. Oudega ◽

Eric van Exel ◽

Mike P. Wattjes ◽

Hannie C. Comijs ◽

Philip Scheltens ◽

...

Keyword(s):

White Matter ◽

Elderly Patients ◽

Temporal Lobe ◽

Electroconvulsive Therapy ◽

Medial Temporal Lobe ◽

White Matter Hyperintensities ◽

Cortical Atrophy ◽

Medial Temporal Lobe Atrophy ◽

Lobe Atrophy

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Contribution of white matter hyperintensities, medial temporal lobe atrophy and cortical atrophy on outcome, seven to twelve years after ECT in severely depressed geriatric patients

Journal of Affective Disorders ◽

10.1016/j.jad.2015.07.011 ◽

2015 ◽

Vol 185 ◽

pp. 144-148 ◽

Cited By ~ 8

Author(s):

Mardien L Oudega ◽

Annemieke Dols ◽

Ilse Adelerhof ◽

Maarten Rozing ◽

Mike P. Wattjes ◽

...

Keyword(s):

White Matter ◽

Temporal Lobe ◽

Medial Temporal Lobe ◽

Geriatric Patients ◽

White Matter Hyperintensities ◽

Cortical Atrophy ◽

Medial Temporal Lobe Atrophy ◽

Lobe Atrophy

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The Beyond Ageing Project Phase 2 - a double-blind, selective prevention, randomised, placebo-controlled trial of omega-3 fatty acids and sertraline in an older age cohort at risk for depression: study protocol for a randomized controlled trial

Trials ◽

10.1186/s13063-015-0762-6 ◽

2015 ◽

Vol 16 (1) ◽

Cited By ~ 12

Author(s):

Nicole L. Cockayne ◽

Shantel L. Duffy ◽

Rosalind Bonomally ◽

Amelia English ◽

Paul G. Amminger ◽

...

Keyword(s):

Fatty Acids ◽

Randomized Controlled Trial ◽

Controlled Trial ◽

Phase 2 ◽

Omega 3 Fatty Acids ◽

Omega 3 ◽

Double Blind ◽

Randomized Controlled ◽

Age Cohort ◽

Selective Prevention

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Medial temporal lobe atrophy, white matter hyperintensities and cognitive impairment among Nigerian African stroke survivors

BMC Research Notes ◽

10.1186/s13104-015-1552-7 ◽

2015 ◽

Vol 8 (1) ◽

Cited By ~ 14

Author(s):

Rufus O. Akinyemi ◽

Michael Firbank ◽

Godwin I. Ogbole ◽

Louise M. Allan ◽

Mayowa O. Owolabi ◽

...

Keyword(s):

Cognitive Impairment ◽

White Matter ◽

Temporal Lobe ◽

Medial Temporal Lobe ◽

White Matter Hyperintensities ◽

Stroke Survivors ◽

Medial Temporal Lobe Atrophy ◽

Lobe Atrophy

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Brain perfusion correlates of medial temporal lobe atrophy and white matter hyperintensities in mild cognitive impairment

Journal of Neurology ◽

10.1007/s00415-006-0498-z ◽

2007 ◽

Vol 254 (8) ◽

pp. 1000-1008 ◽

Cited By ~ 15

Author(s):

Anna Caroli ◽

Cristina Testa ◽

Cristina Geroldi ◽

Flavio Nobili ◽

Ugo P. Guerra ◽

...

Keyword(s):

Cognitive Impairment ◽

Mild Cognitive Impairment ◽

White Matter ◽

Temporal Lobe ◽

Medial Temporal Lobe ◽

White Matter Hyperintensities ◽

Brain Perfusion ◽

Medial Temporal Lobe Atrophy ◽

Lobe Atrophy

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The role of white matter hyperintensities and medial temporal lobe atrophy in age-related executive dysfunctioning

Brain and Cognition ◽

10.1016/j.bandc.2008.03.006 ◽

2008 ◽

Vol 68 (2) ◽

pp. 128-133 ◽

Cited By ~ 33

Author(s):

Joukje M. Oosterman ◽

Raymond L.C. Vogels ◽

Barbera van Harten ◽

Alida A. Gouw ◽

Philip Scheltens ◽

...

Keyword(s):

White Matter ◽

Temporal Lobe ◽

Medial Temporal Lobe ◽

White Matter Hyperintensities ◽

Medial Temporal Lobe Atrophy ◽

Age Related ◽

Lobe Atrophy

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