scholarly journals Morphological alterations of the choroid plexus epithelium in Alzheimer’s disease

2020 ◽  
Vol 16 (S2) ◽  
Author(s):  
Caroline Van Cauwenberghe ◽  
Charysse Vandendriessche ◽  
Anneke Kremer ◽  
Riet De Rycke ◽  
Peter Borghgraef ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Choroid Plexus ◽  
Choroid Plexus Epithelium ◽  
Morphological Alterations

P1-180: AN ULTRASTRUCTURAL STUDY OF THE MORPHOLOGICAL ALTERATIONS OF THE CHOROID PLEXUS EPITHELIUM IN ALZHEIMER'S DISEASE

2006 ◽  
Vol 14 (7S_Part_6) ◽  
pp. P347-P348
Author(s):  
Caroline Van Cauwenberghe ◽  
Charysse Vandendriessche ◽  
Sriram Balusu ◽  
Anneke Kremer ◽  
Riet De Rycke ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Choroid Plexus ◽  
Ultrastructural Study ◽  
Choroid Plexus Epithelium ◽  
Morphological Alterations

Morphological alterations of the choroid plexus in late-onset Alzheimer’s disease

2000 ◽  
Vol 99 (2) ◽  
pp. 105-108 ◽  
Author(s):  
Jean-Marie Serot ◽  
Marie-Christine Béné ◽  
Bernard Foliguet ◽  
Gilbert C. Faure
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Choroid Plexus ◽  
Late Onset ◽  
Morphological Alterations

scholarly journals Astrocytes and Adenosine A2A Receptors: Active Players in Alzheimer’s Disease

2021 ◽  
Vol 15 ◽  
Author(s):  
Cátia R. Lopes ◽  
Rodrigo A. Cunha ◽  
Paula Agostinho
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Β ◽  
The Elderly ◽  
Synaptic Function ◽  
Morphological Alterations ◽  
Functional Changes ◽  
A2a Receptors ◽  
Novel Therapeutic Strategies

Astrocytes, through their numerous processes, establish a bidirectional communication with neurons that is crucial to regulate synaptic plasticity, the purported neurophysiological basis of memory. This evidence contributed to change the classic “neurocentric” view of Alzheimer’s disease (AD), being astrocytes increasingly considered a key player in this neurodegenerative disease. AD, the most common form of dementia in the elderly, is characterized by a deterioration of memory and of other cognitive functions. Although, early cognitive deficits have been associated with synaptic loss and dysfunction caused by amyloid-β peptides (Aβ), accumulating evidences support a role of astrocytes in AD. Astrocyte atrophy and reactivity occurring at early and later stages of AD, respectively, involve morphological alterations that translate into functional changes. However, the main signals responsible for astrocytic alterations in AD and their impact on synaptic function remain to be defined. One possible candidate is adenosine, which can be formed upon extracellular catabolism of ATP released by astrocytes. Adenosine can act as a homeostatic modulator and also as a neuromodulator at the synaptic level, through the activation of adenosine receptors, mainly of A1R and A2AR subtypes. These receptors are also present in astrocytes, being particularly relevant in pathological conditions, to control the morphofunctional responses of astrocytes. Here, we will focus on the role of A2AR, since they are particularly associated with neurodegeneration and also with memory processes. Furthermore, A2AR levels are increased in the AD brain, namely in astrocytes where they can control key astrocytic functions. Thus, unveiling the role of A2AR in astrocytes function might shed light on novel therapeutic strategies for AD.

Contributions of choroid plexus proteins in aging and in Alzheimer's disease

2014 ◽  
Vol 20 (1) ◽  
pp. 19
Author(s):  
J.A. Palha ◽  
S.D. Mesquita ◽  
A.C. Ferreira ◽  
J.C. Sousa ◽  
N.J. Sousa ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Choroid Plexus
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