scholarly journals Tau‐dependent regulation of neuronal activity by the Alzheimer’s disease risk gene BIN1

2020 ◽  
Vol 16 (S3) ◽  
Author(s):  
Yuliya Voskobiynyk ◽  
Jonathan R. Roth ◽  
J. Nicholas Cochran ◽  
Travis Rush ◽  
Nancy V.N. Carullo ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neuronal Activity ◽  
Disease Risk ◽  
Risk Gene

scholarly journals Alzheimer's Disease Risk Gene, GAB2, is Associated with Regional Brain Volume Differences in 755 Young Healthy Twins

2012 ◽  
Vol 15 (3) ◽  
pp. 286-295 ◽  
Author(s):  
Derrek P. Hibar ◽  
Neda Jahanshad ◽  
Jason L. Stein ◽  
Omid Kohannim ◽  
Arthur W. Toga ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Young Adult ◽  
Disease Risk ◽  
Adult Brain ◽  
Brain Morphology ◽  
Control Analysis ◽  
Risk Gene ◽  
Increased Risk ◽  
The Brain

The development of late-onset Alzheimer's disease (LOAD) is under strong genetic control and there is great interest in the genetic variants that confer increased risk. The Alzheimer's disease risk gene, growth factor receptor bound protein 2-associated protein (GAB2), has been shown to provide a 1.27–1.51 increased odds of developing LOAD for rs7101429 major allele carriers, in case-control analysis. GAB2 is expressed across the brain throughout life, and its role in LOAD pathology is well understood. Recent studies have begun to examine the effect of genetic variation in the GAB2 gene on differences in the brain. However, the effect of GAB2 on the young adult brain has yet to be considered. Here we found a significant association between the GAB2 gene and morphological brain differences in 755 young adult twins (469 females) (M = 23.1, SD = 3.1 years), using a gene-based test with principal components regression (PCReg). Detectable differences in brain morphology are therefore associated with variation in the GAB2 gene, even in young adults, long before the typical age of onset of Alzheimer's disease.

scholarly journals Is  -T catenin (VR22) an Alzheimer's disease risk gene?

2006 ◽  
Vol 44 (1) ◽  
pp. e63-e63 ◽  
Author(s):  
L. Bertram ◽  
K. Mullin ◽  
M. Parkinson ◽  
M. Hsiao ◽  
T. J Moscarillo ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Risk ◽  
Risk Gene

scholarly journals An alternative transcript of the Alzheimer's disease risk gene SORL1 encodes a truncated receptor

2018 ◽  
Vol 71 ◽  
pp. 266.e11-266.e24 ◽  
Author(s):  
Jenny Blechingberg ◽  
Annemarie Svane Aavild Poulsen ◽  
Mads Kjølby ◽  
Giulia Monti ◽  
Mariet Allen ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Disease Risk ◽  
Alternative Transcript ◽  
Risk Gene ◽  
Truncated Receptor

scholarly journals cindr, the Drosophila Homolog of the CD2AP Alzheimer’s Disease Risk Gene, Is Required for Synaptic Transmission and Proteostasis

Cell Reports ◽  
2019 ◽  
Vol 28 (7) ◽  
pp. 1799-1813.e5 ◽  
Author(s):  
Shamsideen A. Ojelade ◽  
Tom V. Lee ◽  
Nikolaos Giagtzoglou ◽  
Lei Yu ◽  
Berrak Ugur ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Synaptic Transmission ◽  
Disease Risk ◽  
Risk Gene ◽  
Drosophila Homolog

scholarly journals Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta

Neuron ◽  
2013 ◽  
Vol 78 (4) ◽  
pp. 631-643 ◽  
Author(s):  
Ana Griciuc ◽  
Alberto Serrano-Pozo ◽  
Antonio R. Parrado ◽  
Andrea N. Lesinski ◽  
Caroline N. Asselin ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Beta ◽  
Disease Risk ◽  
Risk Gene

P1-143: Investigating the Role of BIN1 , an Alzheimer's Disease Risk Gene, in Endocytosis at the Blood-Brain Barrier

2016 ◽  
Vol 12 ◽  
pp. P457-P458
Author(s):  
Anna L. Burt ◽  
Rhian S. Thomas ◽  
Melanie L. Dunstan ◽  
Rebecca Sims ◽  
Julie Williams
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Blood Brain Barrier ◽  
Disease Risk ◽  
Brain Barrier ◽  
Risk Gene ◽  
Blood Brain

P4-196: The Alzheimer's disease risk gene bin1 regulates neuronal excitability

2015 ◽  
Vol 11 (7S_Part_18) ◽  
pp. P855-P855
Author(s):  
Jesse Nicholas Cochran ◽  
Travis Rush ◽  
Brian A. Warmus ◽  
Aimee V. Franklin ◽  
Lori L. McMahon ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neuronal Excitability ◽  
Disease Risk ◽  
Risk Gene
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