scholarly journals TOMM40 has genomic effects on hippocampal volume in mid‐life adults independent of APOE ε4 status

2020 ◽  
Vol 16 (S3) ◽  
Author(s):  
Colleen Pappas ◽  
Qian Wang ◽  
Ling Yi Lee ◽  
Scott T. Le ◽  
Brandon S. Klinedinst ◽  
...  
Keyword(s):  
Hippocampal Volume ◽  
Apoe Ε4 ◽  
Genomic Effects

scholarly journals APOE -ε4 associates with hippocampal volume, learning, and memory across the spectrum of Alzheimer's disease and dementia with Lewy bodies

2018 ◽  
Vol 14 (9) ◽  
pp. 1137-1147 ◽  
Author(s):  
Usman Saeed ◽  
Saira S. Mirza ◽  
Bradley J. MacIntosh ◽  
Nathan Herrmann ◽  
Julia Keith ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Learning And Memory ◽  
Dementia With Lewy Bodies ◽  
Lewy Bodies ◽  
Hippocampal Volume ◽  
Apoe Ε4

scholarly journals No Differences in Hippocampal Volume between Carriers and Non-Carriers of the ApoE ε4 and ε2 Alleles in Young Healthy Adolescents

2014 ◽  
Vol 40 (1) ◽  
pp. 37-43 ◽  
Author(s):  
Wasim Khan ◽  
Vincent Giampietro ◽  
Cedric Ginestet ◽  
Flavio Dell'Acqua ◽  
David Bouls ◽  
...  
Keyword(s):  
Hippocampal Volume ◽  
Apoe Ε4

Smaller hippocampal volume in APOE ε4 carriers independent of amyloid-β (Aβ) burden

2021 ◽  
Vol 317 ◽  
pp. 111381
Author(s):  
Hwagyu Suh ◽  
Young-Min Lee ◽  
Je-Min Park ◽  
Byung-Dae Lee ◽  
Eunsoo Moon ◽  
...  
Keyword(s):  
Amyloid Β ◽  
Hippocampal Volume ◽  
Apoe Ε4

Hippocampal Volume Loss, Brain Amyloid Accumulation, and APOE Status in Cognitively Intact Elderly Subjects

2019 ◽  
Vol 19 (3-4) ◽  
pp. 139-147 ◽  
Author(s):  
Sven Haller ◽  
Marie-Louise Montandon ◽  
Cristelle Rodriguez ◽  
Valentina Garibotto ◽  
François R. Herrmann ◽  
...  
Keyword(s):  
Hippocampal Volume ◽  
Elderly Subjects ◽  
Neuropsychological Performance ◽  
Amyloid Pet ◽  
Volume Loss ◽  
Apoe Ε4 ◽  
Amyloid Accumulation ◽  
Ε4 Allele ◽  
The Impact

Background: Hippocampal volume loss (HVL), PET-documented brain amyloid accumulation, and APOE-ε4 status are predictive biomarkers of the transition from mild cognitive impairment to Alzheimer disease (AD). In asymptomatic cases, the role of these biomarkers remains ambiguous. In contrast to the idea that HVL occurs in late phases of neurodegeneration, recent contributions indicate that it might occur before abnormal amyloid PET occurrence in elderly subjects and that its severity could be only marginally related to APOE variants. Using a longitudinal design, we examined the determinants of HVL in our sample, i.e., brain amyloid burden and the presence of APOE-ε4, and made a longitudinal assessment of cognitive functions. Methods: We performed a 4.5-year longitudinal study on 81 elderly community dwellers (all right-handed;, 48 (59.3%) women; mean age 73.7 ± 3.7 years) including MRI at baseline and follow-up, PET amyloid during follow-up, neuropsychological assessment at 18 and 54 months, and APOE genotyping. All cases were assessed using a continuous cognitive score (CCS) that took into account the global evolution of neuropsychological performance. Linear regression models were used to identify predictors of HVL. Results: There was a negative association between the CCS and HVL bilaterally. In multivariate models adjusting for demographic variables, the presence of APOE-ε4 was related to increased HVL bilaterally. A trend of significance was observed with respect to the impact of amyloid positivity on HVL in the left hemisphere. No significant interaction was found between amyloid positivity and the APOE-ε4 allele. Conclusion: The progressive decrement of neuropsychological performance is associated with HVL long before the emergence of clinically overt symptoms. In this cohort of healthy individuals, the presence of the APOE-ε4 allele was shown to be an independent predictor of worst hippocampal integrity in asymptomatic cases independently of amyloid positivity.

006 Effect of apolipoprotein e ε4 allele on medial temporal lobe atrophy in ischaemic stroke patients

2018 ◽  
Vol 89 (6) ◽  
pp. A4.1-A4
Author(s):  
Mohamed Salah Khlif ◽  
Emilio Werden ◽  
Natalia Egorova ◽  
Wasim Khan ◽  
Amy Brodtmann
Keyword(s):  
Cognitive Impairment ◽  
Ischaemic Stroke ◽  
Temporal Lobe ◽  
Medial Temporal Lobe ◽  
Hippocampal Volume ◽  
Stroke Survivors ◽  
Apoe Ε4 ◽  
Ε4 Allele ◽  
The Right ◽  
Time Point

IntroductionApolipoprotein E (APOE) ε4 allele is a known risk factor for the development of cognitive impairment. APOE ε4 carriers have been reported as having lower hippocampal volume in Alzheimer’s disease, mild cognitive impairment, and in healthy cohorts,1 but this is not well investigated in stroke. Here, we compared the regional volume in the medial temporal lobe in ischaemic stroke survivors, with and without the ε4 allele, three (time point 1, t1) and twelve (t2) months after stroke.Methods21 APOE ε4 carriers and 21 non-carriers, matched for lesion size and location and for neurological impairment as measured by NIHSS, were sampled from the CANVAS study, a longitudinal imaging study in stroke survivors.2 A mixed-effect linear model was used to analyse the effect of the ε4 allele on hippocampal, entorhinal, and para-hippocampal volumes, adjusting for age, sex, years of education, and total intracranial volume. Volumes were estimated using the longitudinal stream in FreeSurfer 5.3.ResultsThe left hippocampal (pt1=0.038, pt2=0.040) and entorhinal (pt1=0.044, pt2=0.038) volumes were significantly lower in the ε4-carrier group at each time point. The right entorhinal (pt1=pt2=0.002) and para-hippocampal (pt1=0.018, pt2=0.020) volumes were also significantly lower in the ε4-carrier group, but there was no difference in the right hippocampal volume (pt1=pt2=0.055) between the two groups. The group-time interaction was significant for the left para-hippocampal cortex (p=0.019): ε4 non-carriers showed a significant volume increase (p=0.018) between t1 and t2.ConclusionThese findings suggest that stroke survivors who carry the APOE-ε4 allele will experience greater atrophy in the medial temporal lobe in the twelve months following their stroke.References1. Manning EN, et al. e4 Is Associated with Disproportionate Progressive Hippocampal Atrophy in AD. PLoS ONE2014;9(5):e97608.2. Brodtmann A, et al. Charting cognitive and volumetric trajectories after stroke: Protocol for the Cognition And Neocortical Volume After Stroke (CANVAS) study. Int J Stroke2014;9(6):824–828.

The association between physical activity intensity, cognition and brain structure in people with type 2 diabetes

2021 ◽  
Author(s):  
Fateme Zabetian-Targhi ◽  
Velandai K Srikanth ◽  
Richard Beare ◽  
Monique Breslin ◽  
Chris Moran ◽  
...  
Keyword(s):  
Physical Activity ◽  
Type 2 Diabetes ◽  
Insulin Therapy ◽  
Processing Speed ◽  
Brain Structure ◽  
Hippocampal Volume ◽  
Step Count ◽  
Apoe Ε4 ◽  
Activity Intensity

Abstract Background Physical inactivity is a risk factor for type 2 diabetes (T2D) and dementia. However, it is unknown if physical activity (PA) intensity is associated with brain health in people with T2D. Therefore, this study aimed to determine 1) associations between PA intensity and step count with both cognition and brain structure and 2) if apolipoprotein E-ε4 (APOE-ε4) or insulin-therapy modifies any associations. Methods Participants were people with T2D (n=220; aged 55-86 years). An accelerometer worn over the left hip was used to obtain step count and moderate-to-vigorous PA (MVPA) averaged over 7 days. Cognition in 7 domains was obtained using a battery of neuropsychological tests. Brain structure was measured by Magnetic Resonance Imaging (MRI). Linear regression models were used to examine associations between step count, MVPA and each cognitive and MRI measure. APOE-ε4 x PA and insulin-therapy x PA product terms were added to the models to examine effect modification. Results The mean age of participants was 67.9 (SD 6.3). Higher step count was associated with greater hippocampal volume (β=0.028 95%CI 0.005, 0.051). Insulin-therapy modified the association between MVPA and attention-processing speed, such that associations were significant in people receiving insulin-therapy (P for interaction=0.019). There were no other significant associations. Conclusions Higher step count and greater time spent in MVPA may be associated with better hippocampal volume and attention-processing speed respectively in people with T2D. People with greater diabetes severity (receiving insulin-therapy) may get more cognitive benefit from MVPA.

Interactions Between Physical Activity and APOE-ε4 Risk for Alzheimer’s Disease on Longitudinal Hippocampal Volume Change

2014 ◽  
Vol 46 ◽  
pp. 282
Author(s):  
J. Carson Smith ◽  
Kristy A. Nielson ◽  
John L. Woodard ◽  
Michael Seidenberg ◽  
Cassandra C. Kandah ◽  
...  
Keyword(s):  
Physical Activity ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Volume Change ◽  
Hippocampal Volume ◽  
Apoe Ε4

scholarly journals APOE‐ε4 and hippocampal volume in the cognitively healthy elderly: Longitudinal analysis reveals origins of apparent cross‐sectional differences

2020 ◽  
Vol 16 (S4) ◽  
Author(s):  
Linda Zhang ◽  
Eva Duenas ◽  
Christopher Long ◽  
Susana Navas ◽  
Miguel Calero ◽  
...  
Keyword(s):  
Longitudinal Analysis ◽  
Hippocampal Volume ◽  
Cross Sectional ◽  
Apoe Ε4 ◽  
Healthy Elderly

scholarly journals Blood NCAPH2 Methylation Is Associated With Hippocampal Volume in Subjective Cognitive Decline With Apolipoprotein E ε4 Non-carriers

2021 ◽  
Vol 13 ◽  
Author(s):  
Ying Chen ◽  
Tao-Ran Li ◽  
Shu-Wen Hao ◽  
Xiao-Ni Wang ◽  
Yan-Ning Cai ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Apolipoprotein E ◽  
Early Stage ◽  
Structural Mri ◽  
Hippocampal Volume ◽  
Subjective Cognitive Decline ◽  
Cognitively Normal ◽  
Apoe Ε4 ◽  
Neuropsychological Assessments ◽  
Normal Controls

Objective: This study assessed the methylation of peripheral NCAPH2 in individuals with subjective cognitive decline (SCD), identified its correlation with the hippocampal volume, and explored whether the correlation is influenced by apolipoprotein E ε4 (APOE ε4) status.Methods: Cognitively normal controls (NCs, n = 56), individuals with SCD (n = 81), and patients with objective cognitive impairment (OCI, n = 51) were included from the Sino Longitudinal Study on Cognitive Decline (NCT03370744). All participants completed neuropsychological assessments, blood tests, and structural MRI. NCAPH2 methylation was compared according to the diagnostic and APOE ε4 status. Partial correlation analysis was conducted to assess the correlations between the hippocampal volume, cognitive tests, and the NCAPH2 methylation levels.Results: Individuals with SCD and patients with OCI showed significantly lower levels of NCAPH2 methylation than NCs, which were independent of the APOE ε4 status. The NCAPH2 methylation levels and the hippocampal volumes were positively correlated in the SCD APOE ε4 non-carriers but not in the OCI group. No association was found between the NCAPH2 methylation levels and the cognitive function.Conclusion: Abnormal changes in blood NCAPH2 methylation were found to occur in SCD, indicating its potential to be used as a useful peripheral biomarker in the early stage of Alzheimer's disease screening.

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