scholarly journals Informant's perceptions and objective cognitive decline among Mexican older adults with a history of traumatic brain injury with and without loss of consciousness

2020 ◽  
Vol 16 (S6) ◽  
Author(s):  
Stefanie Danielle Piña‐Escudero ◽  
Roberto de Jesús García Aviles ◽  
Anna H. Chodos ◽  
Christine S. Ritchie ◽  
Jose Alberto Avila
Keyword(s):  
Older Adults ◽  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Cognitive Decline ◽  
Loss Of Consciousness ◽  
History Of

Cognitive decline in older adults with a history of traumatic brain injury

2012 ◽  
Vol 11 (12) ◽  
pp. 1103-1112 ◽  
Author(s):  
Laura Moretti ◽  
Irene Cristofori ◽  
Starla M Weaver ◽  
Aileen Chau ◽  
Jaclyn N Portelli ◽  
...  
Keyword(s):  
Older Adults ◽  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Cognitive Decline ◽  
History Of

Association of Military Employment With Late-Life Cognitive Decline and Dementia: A Population-Based Prospective Cohort Study

2021 ◽  
Author(s):  
Melinda C Power ◽  
Alia E Murphy ◽  
Kan Z Gianattasio ◽  
Y i Zhang ◽  
Rod L Walker ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Cohort Study ◽  
Brain Injury ◽  
Cognitive Decline ◽  
Late Life ◽  
Cognitive Change ◽  
Effect Modification ◽  
Sensitivity Analyses ◽  
Loss Of Consciousness ◽  
Increased Risk

ABSTRACT Introduction As the number of U.S. veterans over age 65 has increased, interest in whether military service affects late-life health outcomes has grown. Whether military employment is associated with increased risk of cognitive decline and dementia remains unclear. Materials and Methods We used data from 4,370 participants of the longitudinal Adult Changes in Thought (ACT) cohort study, enrolled at age 65 or older, to examine whether military employment was associated with greater cognitive decline or higher risk of incident dementia in late life. We classified persons as having military employment if their first or second-longest occupation was with the military. Cognitive status was assessed at each biennial Adult Changes in Thought study visit using the Cognitive Abilities Screening Instrument, scored using item response theory (CASI-IRT). Participants meeting screening criteria were referred for dementia ascertainment involving clinical examination and additional cognitive testing. Primary analyses were adjusted for sociodemographic characteristics and APOE genotype. Secondary analyses additionally adjusted for indicators of early-life socioeconomic status and considered effect modification by age, gender, and prior traumatic brain injury with loss of consciousness TBI with LOC. Results Overall, 6% of participants had military employment; of these, 76% were males. Military employment was not significantly associated with cognitive change (difference in modeled 10-year cognitive change in CASI-IRT scores in SD units (95% confidence interval [CI]): −0.042 (−0.19, 0.11), risk of dementia (hazard ratio [HR] [95% CI]: 0.92 [0.71, 1.18]), or risk of Alzheimer’s disease dementia (HR [95% CI]: 0.93 [0.70, 1.23]). These results were robust to additional adjustment and sensitivity analyses. There was no evidence of effect modification by age, gender, or traumatic brain injury with loss of consciousness. Conclusions Among members of the Adult Changes in Thought cohort, military employment was not associated with increased risk of cognitive decline or dementia. Nevertheless, military veterans face the same high risks for cognitive decline and dementia as other aging adults.

scholarly journals SENSITIVITY OF SELF-REPORTED COMORBIDITIES COMPARED TO MEDICARE CLAIMS IN OLDER ADULTS WITH TRAUMATIC BRAIN INJURY

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S483-S483
Author(s):  
Aparna Vadlamani ◽  
Jennifer Albrecht
Keyword(s):  
Older Adults ◽  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Medical History ◽  
Acute Injury ◽  
Administrative Claims ◽  
Comorbid Illness ◽  
Medicare Claims ◽  
Patient Reported ◽  
History Of

Abstract Patient reported history of comorbid illness may be the only information available to the treatment team during an acute injury admission. Nevertheless, acute injury, particularly traumatic brain injury (TBI) which affects cognition, may decrease the patient’s ability to accurately report medical history. Thus, the objective of this study was to evaluate the accuracy of patient-reported comorbid illness burden compared to the patient’s Medicare administrative claims. Records of older adults treated for TBI at an urban level 1 trauma center 2006-2010 were linked to their Medicare administrative. Comorbidities were recorded in Medicare claims based on ICD9 codes and were reported in the trauma registry (TR) based on patient medical history recorded by a physician or nurse. Prevalence of each of the following comorbidities was calculated using information from the TR and claims: Alzheimer’s disease and related dementias, chronic kidney disease, COPD, heart failure, diabetes, depression, stroke, and hypertension. Sensitivity of each patient-reported comorbidity was calculated using Medicare claims as the gold standard. We identified patient factors associated with accurate self-report using logistic regression. Among 408 older adults with TBI that linked to their Medicare claims, prevalence of each comorbidity was higher in Medicare claims compared to the TR, except for hypertension. Sensitivity for detecting these comorbidities using the TR ranged from 2% to 68%, with the highest sensitivity observed for hypertension. Older age and race were predictors of less accurate reported medical history. Reconciling self-reported patient history of these comorbidities with those reported in claims can better inform decisions regarding treatment.

Evidence of cognitive decline in older adults after remote traumatic brain injury: an exploratory study

2014 ◽  
Vol 22 (5) ◽  
pp. 517-533 ◽  
Author(s):  
Lana J. Ozen ◽  
Myra A. Fernandes ◽  
Amanda J. Clark ◽  
Eric A. Roy
Keyword(s):  
Older Adults ◽  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Cognitive Decline ◽  
Exploratory Study

Lifetime prevalence of traumatic brain injury with loss of consciousness

2017 ◽  
Vol 24 (6) ◽  
pp. 396-404 ◽  
Author(s):  
John D Corrigan ◽  
Jingzhen Yang ◽  
Bhavna Singichetti ◽  
Kara Manchester ◽  
Jennifer Bogner
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Behavioral Risk ◽  
Loss Of Consciousness ◽  
Lifetime History ◽  
Behavioral Risk Factor Surveillance ◽  
Risk Factor Surveillance ◽  
Prevalence Estimates ◽  
History Of ◽  
Severe Tbi

ObjectiveTo determine the prevalence of lifetime history of traumatic brain injury (TBI) with loss of consciousness (LOC) among adult, non-institutionalised residents of Ohio.MethodsWe analysed data from 2014 Ohio Behavioral Risk Factor Surveillance System, which included a state-specific module designed to elicit lifetime history of TBI.ResultsOf non-institutionalised adults 18 years and over living in Ohio, 21.7% reported at least one lifetime TBI with LOC, 2.6% experienced at least one moderate or severe such injury, 9.1% experienced a TBI with LOC before age 15 years and 10.8% experienced either TBI with LOC before age 15 years or a moderate or severe injury. Males, those with lower incomes and those unable to work were more likely to have incurred at least one TBI with LOC, multiple TBIs with LOC, a moderate or severe TBI and a TBI with LOC before age15.ConclusionsOne in five adults experienced TBIs of sufficient severity to cause LOC; 3% experienced at least one moderate or severe TBI and almost 10% experienced a first TBI with LOC before the age of 15 years. The prevalence of lifetime TBI in the present study suggests that there may be a substantially greater burden of injury than concluded from previous prevalence estimates.

scholarly journals Social support buffers against cognitive decline in single mild traumatic brain injury with loss of consciousness: Results from the Canadian Longitudinal Study on Aging

2020 ◽  
Author(s):  
Marc Bedard ◽  
Vanessa Taler
Keyword(s):  
Social Support ◽  
Traumatic Brain Injury ◽  
Longitudinal Study ◽  
Brain Injury ◽  
Cognitive Function ◽  
Cognitive Decline ◽  
Mild Traumatic Brain Injury ◽  
Loss Of Consciousness ◽  
Initial Examination

Abstract Objectives We investigated rates of cognitive decline at three-year follow-up from initial examination in people reporting mild traumatic brain injury (mTBI) with loss of consciousness (LOC) more than a year prior to initial examination. We examined the role of social support as predictors of preserved cognitive function in this sample. Method Analyses were conducted on 440 participants who had self-reported LOC of < 1 min, 350 with LOC of 1-20 min, and 10,712 healthy controls, taken from the Canadian Longitudinal Study on Aging (CLSA), a nationwide study on health and aging. Results People who reported at baseline that they had experienced mTBI with LOC of 1-20 min more than a year prior were 60% more likely to have experienced global cognitive decline than controls at three-year follow-up. Cognitive decline was most apparent on measures of executive functioning. Logistic regression identified increased social support as predictors of relatively preserved cognitive function. Discussion mTBI with longer time spent unconscious (i.e., LOC 1-20 min) is associated with greater cognitive decline years after the head injury. Perceived social support, particularly emotional support may help buffer against this cognitive decline.

scholarly journals Traumatic Brain Injury Exposure Lowers Age of Cognitive Decline in AD and Non-AD Conditions

2021 ◽  
Vol 12 ◽  
Author(s):  
Diego Iacono ◽  
Sorana Raiciulescu ◽  
Cara Olsen ◽  
Daniel P. Perl
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Cognitive Decline ◽  
Neuropsychiatric Symptoms ◽  
Apoe Genotype ◽  
Brain Diseases ◽  
Trail Making Test ◽  
Test Part ◽  
History Of ◽  
Trail Making

We aimed to detect the possible accelerating role of previous traumatic brain injury (TBI) exposures on the onset of later cognitive decline assessed across different brain diseases. We analyzed data from the National Alzheimer's Coordinating Center (NACC), which provide information on history of TBI and longitudinal data on cognitive and non-cognitive domains for each available subject. At the time of this investigation, a total of 609 NACC subjects resulted to have a documented history of TBI. We compared subjects with and without a history of previous TBI (of any type) at the time of their first cognitive decline assessment, and termed them, respectively, TBI+ and TBI– subjects. Three hundred and sixty-one TBI+ subjects (229 male/132 female) and 248 TBI– subjects (156 male/92 female) were available. The analyses included TBI+ and TBI– subjects with a clinical diagnosis of Mild Cognitive Impairment, Alzheimer's disease, Dementia with Lewy bodies, Progressive supranuclear palsy, Corticobasal degeneration, Frontotemporal dementia, Vascular dementia, non-AD Impairment, and Parkinson's disease. The data showed that the mean age of TBI+ subjects was lower than TBI– subjects at the time of their first cognitive decline assessment (71.6 ± 11.2 vs. 74.8 ± 9.5 year; p < 0.001). Moreover, the earlier onset of cognitive decline in TBI+ vs. TBI– subjects was independent of sex, race, attained education, APOE genotype, and importantly, clinical diagnoses. As for specific cognitive aspects, MMSE, Trail Making Test part B and WAIS-R scores did not differ between TBI+ and TBI– subjects, whereas Trail Making Test part A (p = 0.013) and Boston Naming test (p = 0.008) did. In addition, data showed that neuropsychiatric symptoms [based on Neuropsychiatry Inventory (NPI)] were much more frequent in TBI+ vs. TBI– subjects, including AD and non-AD neurodegenerative conditions such as PD. These cross-sectional analyses outcomes from longitudinally-assessed cohorts of TBI+ subjects that is, subjects with TBI exposure before the onset of cognitive decline in the contest of different neurodegenerative disorders and associated pathogenetic mechanisms, are novel, and indicate that a previous TBI exposure may act as a significant “age-lowering” factor on the onset of cognitive decline in either AD and non-AD conditions independently of demographic factors, education, APOE genotype, and current or upcoming clinical conditions.

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