scholarly journals Effect of carbamylated erythropoietin FC fusion protein (CEPO‐FC) on learning and memory impairment and hippocampal apoptosis induced by intracerebroventricular administration of streptozotocin in rats

2020 ◽  
Vol 16 (S2) ◽  
Author(s):  
Maryam Moosavi ◽  
Etrat Hooshmandi ◽  
Pegah Javadpour ◽  
Nader Maghsoudi ◽  
Hermann Katinger ◽  
...  
Keyword(s):  
Fusion Protein ◽  
Learning And Memory ◽  
Memory Impairment ◽  
Intracerebroventricular Administration ◽  
Fc Fusion Protein ◽  
Hippocampal Apoptosis ◽  
Carbamylated Erythropoietin

scholarly journals Protective Effects of Atorvastatin and Rosuvastatin on 3,4-methylenedioxymethamphetamine (MDMA)-Induced Spatial Learning and Memory Impairment

2021 ◽  
Author(s):  
Majid Eslami ◽  
Laleh Khorshidi ◽  
Maryam Ghasemi ◽  
Amir Rashidian ◽  
Mahdi Mirghazanfari ◽  
...  
Keyword(s):  
Learning And Memory ◽  
Memory Impairment ◽  
Caspase 3 ◽  
Spatial Learning And Memory ◽  
Ros Production ◽  
Protective Effects ◽  
Memory Functions ◽  
Male Wistar Rats ◽  
Coa Reductase ◽  
Hippocampal Apoptosis

Abstract 3,4‐methylenedioxymethamphetamine (MDMA) or "Ecstasy", which has been used for recreational purposes, is shown to cause learning and memory impairment. Statins, beyond their efficient cholesterol-lowering action through inhibition of 3-hydroxy-3-methylglutaryl-CoA (HMG-COA) reductase, possess multiple neuroprotective impacts referred to as pleiotropic effects. In this regard, we aimed to investigate the protective effect of atorvastatin and rosuvastatin in MDMA-induced neurotoxicity. Adult male Wistar rats received atorvastatin (5, 10, 20 mg/kg; orally) and rosuvastatin (5, 10, 20 mg/kg; orally) for 21 consecutive days. Then, Morris water maze (MWM) was performed to examine learning and memory functions. Rats were injected with MDMA (2.5, 5, and 10 mg/kg; I.P) 30 min before training sessions in 4 training days of MWM task. Afterward, rats were sacrificed under general anesthesia and their hippocampuses were dissected to evaluate reactive oxygen species (ROS) production, lipid peroxidation (LPO), and caspase-3 and -9 activities. Our Findings showed that MDMA impaired spatial memory functions and dramatically upregulated ROS production, LPO, and caspase-3 and 9 activities. Also, atorvastatin (5, 10, 20 mg/kg) and rosuvastatin (20 mg/kg) significantly improved memory performances and inhibited upregulation of ROS, LPO, and caspase-3 and -9 activities induced by MDMA. In conclusion, the amelioration of MDMA-induced memory impairment and hippocampal apoptosis through atorvastatin and rosuvastatin could be accredited to the observed suppression of ROS production, LPO, and caspase-3 and -9 activities, since excessive exposure of hippocampus to oxidative stress enhanced apoptotic caspases activities, promoted to neuronal apoptosis.

scholarly journals The neuroprotective and neurorescue effects of carbamylated erythropoietin Fc fusion protein (CEPO-Fc) in a rat model of Parkinson’s disease

2013 ◽  
Vol 1502 ◽  
pp. 55-70 ◽  
Author(s):  
Judith Thomas Tayra ◽  
Masahiro Kameda ◽  
Takao Yasuhara ◽  
Takashi Agari ◽  
Tomohito Kadota ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Fusion Protein ◽  
Rat Model ◽  
Fc Fusion Protein ◽  
Carbamylated Erythropoietin

scholarly journals Anti-Tumor Activity and Pharmacokinetics of AP25-Fc Fusion Protein

2019 ◽  
Vol 16 (7) ◽  
pp. 1032-1041
Author(s):  
Dening Pei ◽  
Jialiang Hu ◽  
Chunming Rao ◽  
Pengcheng Yu ◽  
Hanmei Xu ◽  
...  
Keyword(s):  
Fusion Protein ◽  
Fc Fusion Protein ◽  
Anti Tumor Activity

scholarly journals Systemic administration of monovalent follistatin-like 3-Fc-fusion protein increases muscle mass in mice

iScience ◽  
2021 ◽  
pp. 102488
Author(s):  
Takayuki Ozawa ◽  
Masato Morikawa ◽  
Yasuyuki Morishita ◽  
Kazuki Ogikubo ◽  
Fumiko Itoh ◽  
...  
Keyword(s):  
Fusion Protein ◽  
Muscle Mass ◽  
Systemic Administration ◽  
Fc Fusion Protein
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