scholarly journals Associations between white matter hyperintensities and cognitive dysfunction in Alzheimer’s, vascular and mixed dementias

2020 ◽  
Vol 16 (S5) ◽  
Author(s):  
Hyunwoo Lee ◽  
Vanessa Wiggermann ◽  
Alexander Rauscher ◽  
Mirza Faisal Beg ◽  
Karteek Popuri ◽  
...  
Keyword(s):  
White Matter ◽  
Cognitive Dysfunction ◽  
White Matter Hyperintensities

Abstract P366: High Burden of Tract-Specific White Matter Hyperintensities Relates to Impaired Microstructural Integrity of Distal White Matter Tracts in Community-Dwelling Elders

Stroke ◽  
2021 ◽  
Vol 52 (Suppl_1) ◽  
Author(s):  
YANPENG LIU ◽  
YIWEI XIA ◽  
XIAOXIAO WANG ◽  
YI WANG ◽  
LUMENG YANG ◽  
...  
Keyword(s):  
Executive Function ◽  
White Matter ◽  
Cognitive Dysfunction ◽  
White Matter Hyperintensities ◽  
Brain Mri ◽  
Mean Diffusivity ◽  
Community Dwelling ◽  
Superior Longitudinal Fasciculus ◽  
High Burden ◽  
Microstructural Integrity

Background and purpose: White matter hyperintensities (WMH) are common in elderly individuals and contribute to age-related cognitive dysfunction. Converging evidence indicates that WMH affect white matter (WM) microstructural integrity in WMH and their penumbra. We aimed to investigate whether this effect extends to the distal WM tracts, and to examine the association between distal WM microstructural integrity and cognitive dysfunction in community-dwelling elderly people. Methods: Brain MRI data including FLAIR and DTI sequences of 174 participants (74 ± 5 years) of the Shanghai Aging Study (SAS) were collected and analyzed. For each participant, WMH lesions were segmented automatically. Eighteen major WM tracts were reconstructed using automated quantitative tractography, and the mean diffusivity (MD) of distal WM tracts (excluding an area of 12 mm around the WMH) was calculated. Multivariable linear regression was performed. Results: A high burden of tract-specific WMH was related to a high MD of distal WM tracts in the forceps major (FMA), anterior thalamic radiations (ATR), cingulum cingulate gyrus (CCG), corticospinal tract (CST), superior longitudinal fasciculus-parietal (SLFP), superior longitudinal fasciculus-temporal (SLFT), and uncinate fasciculus (UNC). Furthermore, a high MD of distal tracts was linked to worse attention and executive function in the forceps minor (FMI), right CCG, left inferior longitudinal fasciculus (ILF), SLFP, SLFT and UNC. Conclusions: The effect of WMH on the microstructural integrity of WM tracts may propagate along tracts to distal regions farther than the penumbra and eventually might affect attention and executive function.

scholarly journals White Matter Hyperintensities and Cognitive Dysfunction in Patients With Infratentorial Stroke

2014 ◽  
Vol 38 (5) ◽  
pp. 620 ◽  
Author(s):  
Tae Won Kim ◽  
Yun-Hee Kim ◽  
Kang Hee Kim ◽  
Won Hyuk Chang
Keyword(s):  
White Matter ◽  
Cognitive Dysfunction ◽  
White Matter Hyperintensities

White Matter Hyperintensities and Cognitive Dysfunction in Alzheimer Disease

2009 ◽  
Vol 22 (3) ◽  
pp. 207-212 ◽  
Author(s):  
Jae-Hyeok Heo ◽  
Soon-Tae Lee ◽  
Kon Chu ◽  
Hyun-Jung Park ◽  
Ji-Young Shim ◽  
...  
Keyword(s):  
White Matter ◽  
Alzheimer Disease ◽  
Cognitive Dysfunction ◽  
White Matter Hyperintensities

Cognitive dysfunction and white matter hyperintensities in Fabry disease

2022 ◽  
Author(s):  
P. Murphy ◽  
F. Williams ◽  
I. Davagnanam ◽  
E. Chan ◽  
E. Murphy ◽  
...  
Keyword(s):  
White Matter ◽  
Fabry Disease ◽  
Cognitive Dysfunction ◽  
White Matter Hyperintensities

P4-078: White matter hyperintensities and cognitive dysfunction in Alzheimer's disease

2008 ◽  
Vol 4 ◽  
pp. T691-T691
Author(s):  
Jae-Hyeok Heo ◽  
Min Ky Kim ◽  
Jin Young Ahn ◽  
Tai Hwan Park ◽  
Soon-Tae Lee ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Cognitive Dysfunction ◽  
White Matter Hyperintensities

Cerebral White Matter Atrophy and Cognitive Dysfunction Following TBI

2007 ◽  
Author(s):  
Tracy D. Vannorsdall ◽  
Vani Rao ◽  
David J. Schretlen
Keyword(s):  
White Matter ◽  
Cognitive Dysfunction ◽  
Cerebral White Matter
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