scholarly journals Subjective cognitive decline is associated with longitudinal cerebral blood flow reductions and gray matter atrophy in older adults

2020 ◽  
Vol 16 (S6) ◽  
Author(s):  
Hailey A. Kresge ◽  
Dandan Liu ◽  
Omair A. Khan ◽  
Ujwala Pamidimukkala ◽  
Francis E. Cambronero ◽  
...  
Keyword(s):  
Older Adults ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Cognitive Decline ◽  
Gray Matter ◽  
Subjective Cognitive Decline ◽  
Gray Matter Atrophy

Altered mismatch response precedes gray matter atrophy in subjective cognitive decline

2021 ◽  
Author(s):  
Chia‐Hsiung Cheng ◽  
Chiung‐Chih Chang ◽  
Yi‐Ping Chao ◽  
Hsinjie Lu ◽  
Shih‐Wei Peng ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Gray Matter ◽  
Subjective Cognitive Decline ◽  
Gray Matter Atrophy

P4-173: Elevated Cerebral Blood Flow in Participants with Subjective Cognitive Decline

2016 ◽  
Vol 12 ◽  
pp. P1084-P1084
Author(s):  
John D. West ◽  
Shannon L. Risacher ◽  
Pratik K. Gandhi ◽  
Yu-Chien Wu ◽  
Eileen F. Tallman ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Cognitive Decline ◽  
Subjective Cognitive Decline

scholarly journals P4-595: INCREASED HIPPOCAMPAL CEREBRAL BLOOD FLOW IN OLDER ADULTS WITH OBJECTIVELY-MEASURED SUBTLE COGNITIVE DECLINE

2019 ◽  
Vol 15 ◽  
pp. P1552-P1553
Author(s):  
Jessica R. Osuna ◽  
Kelsey R. Thomas ◽  
Alexandra J. Weigand ◽  
Mark W. Bondi ◽  
Katherine J. Bangen
Keyword(s):  
Older Adults ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Cognitive Decline ◽  
Objectively Measured

scholarly journals Microstructural and Cerebral Blood Flow Abnormalities in Subjective Cognitive Decline Plus: Diffusional Kurtosis Imaging and Three-Dimensional Arterial Spin Labeling Study

2021 ◽  
Vol 13 ◽  
Author(s):  
Zhongxian Yang ◽  
Yu Rong ◽  
Zhen Cao ◽  
Yi Wu ◽  
Xinzhu Zhao ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Cognitive Decline ◽  
Arterial Spin Labeling ◽  
Verbal Learning ◽  
Three Dimensional ◽  
Mean Diffusivity ◽  
Spin Labeling ◽  
Subjective Cognitive Decline ◽  
Diffusional Kurtosis Imaging

Objective: To explore microstructural and cerebral blood flow (CBF) abnormalities in individuals with subjective cognitive decline plus (SCD plus) using diffusional kurtosis imaging (DKI) and three-dimensional (3D) arterial spin labeling (ASL).Methods: Twenty-seven patients with SCD plus, 31 patients with amnestic mild cognitive impairment (aMCI), and 33 elderly controls (ECs) were recruited and underwent DKI and 3D ASL using a GE 3.0-T MRI. Mean kurtosis (MK), fractional anisotropy (FA), mean diffusivity (MD), and CBF values were acquired from 24 regions of interest (ROIs) in the brain, including the bilateral hippocampal (Hip) subregions (head, body, and tail), posterior cingulate cortex (PCC), precuneus, dorsal thalamus subregions (anterior nucleus, ventrolateral nucleus, and medial nucleus), lenticular nucleus, caput nuclei caudati, white matter (WM) of the frontal lobe, and WM of the occipital lobe. Pearson's correlation analysis was performed to assess the relationships among the DKI-derived parameters, CBF values, and key neuropsychological tests for SCD plus.Results: Compared with ECs, participants with SCD plus showed a significant decline in MK and CBF values, mainly in the Hip head and PCC, and participants with aMCI exhibited more significant abnormalities in the MK and CBF values than individuals with ECs and SCD plus in multiple regions. Combined MK values showed better discrimination between patients with SCD plus and ECs than that obtained using CBF levels, with areas under the receiver operating characteristic (ROC) curve (AUC) of 0.874 and 0.837, respectively. Similarly, the AUC in discriminating SCD plus from aMCI patients obtained using combined MK values was 0.823, which was also higher than the combined AUC of 0.779 obtained using CBF values. Moreover, MK levels in the left Hip (h) and left PCC positively correlated with the auditory verbal learning test-delayed recall (AVLT-DR) score in participants with SCD plus. By contrast, only the CBF value in the left Hip head positively correlated with the AVLT-DR score.Conclusions: Our results provide new evidence of microstructural and CBF changes in patients with SCD plus. MK may be used as an early potential neuroimaging biomarker and may be a more sensitive DKI parameter than CBF at the very early stage of Alzheimer's disease (AD).

IC-P-092: Elevated Cerebral Blood Flow in Participants with Subjective Cognitive Decline

2016 ◽  
Vol 12 ◽  
pp. P70-P71 ◽  
Author(s):  
John D. West ◽  
Shannon L. Risacher ◽  
Pratik K. Gandhi ◽  
Yu-Chien Wu ◽  
Eileen F. Tallman ◽  
...  
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Cognitive Decline ◽  
Subjective Cognitive Decline

scholarly journals The Role of Electrode Size on the Incidence of Spreading Depression and on Cortical Cerebral Blood Flow as Measured by H2 Clearance

1992 ◽  
Vol 12 (2) ◽  
pp. 230-237 ◽  
Author(s):  
Marleen J. Verhaegen ◽  
Michael M. Todd ◽  
David S. Warner ◽  
Bruce James ◽  
Julie B. Weeks
Keyword(s):  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Gray Matter ◽  
Spreading Depression ◽  
Insertion Depth ◽  
Flow Measurements ◽  
Electrode Size ◽  
Cortical Gray Matter ◽  
The Right

Cerebral blood flow was measured by the H2 clearance method 30 and 60 min after the implantation of 300, 250, 125, or 50 μm diameter platinum–iridium electrodes 2 mm deep into the right parietal cortex of normothermic, normocarbic halothane-anesthetized rats. Another group of animals had 50 μm electrodes inserted 1 mm. In all animals, the presence or absence of a wave of spreading depression (SD) was noted at the time of implantation, with recordings made with glass micropipettes. H2 flow values were compared with those measured in gray matter from the same anatomical region (but from different rats), using [3H]nicotine. The incidence of SD ranged from 60% following insertion of 300 μm electrodes to 0% with 50 μm electrodes. H2 clearance flows also varied with electrode size, from 77 ± 21 ml 100 g−1 min−1 (mean ± standard deviation) with 300 μm electrodes to 110 ± 31 and 111 ± 16 ml 100 g−1 min−1 with 125 and 50 μm electrodes, respectively (insertion depth of 2 mm). A CBF value of 155 ± 60 ml 100 g−1 min−1 was obtained with 50 μm electrodes inserted only 1 mm. Cortical gray matter blood flow measured with [3H]nicotine was 154 ± 35 ml 100 g−1 min−1. When the role of SD in subsequent flow measurements was examined, there was a gradual increase in CBF between 30 and 60 min after electrode insertion in those animals with SD, while no such change was seen in rats without SD. These results indicate that the choice of electrode size and implantation depth influences the measurement of CBF by H2 clearance. CBF values equivalent to those obtained with isotopic techniques can be acutely obtained with small (50 μm diameter) electrodes inserted 1 mm into the cortex. While the occurrence of SD does influence CBF in the period immediately after implantation, a relationship between electrode size and measured flow is present that is independent of SD.

scholarly journals Likelihood of Participation in Home-Based Cognitive Assessment: The Role of Subjective Cognitive Decline and Age

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 293-294
Author(s):  
Moriah Splonskowski ◽  
Holly Cooke ◽  
Claudia Jacova
Keyword(s):  
Older Adults ◽  
Cognitive Decline ◽  
Old Age ◽  
Cognitive Assessment ◽  
Community Dwelling ◽  
Subjective Cognitive Decline ◽  
Cognitive State ◽  
Home Based ◽  
Increased Risk

Abstract Home-based cognitive assessment (HBCA) services are emerging as a convenient alternative to in-clinic cognitive assessment and may aid in mitigating barriers to detecting cognitive impairment (CI). It is unknown which older adults would be likely to participate in HBCA. Here we investigated the role of age and Subjective Cognitive Decline (SCD). SCD has demonstrated an increased risk for progression to CI/dementia. A nation-wide community-dwelling sample of 494 adults age 50+ were recruited via Amazon Mechanical Turk to complete an online survey assessing perceptions around HBCA and SCD. Our sample was 91.9% White and 66.8% female. It consisted of 174 respondents aged 50-60, 265 aged 61- 70, and 55 aged 71-79. Age groups were comparable with respect to their acceptance of cognitive assessment (Range 4-20, higher score=higher acceptance, 7.9±3.3, 8.15±3.2, 8.05±3.43) and SCD-Q total (43.1±5.8, 43.2±5.7, 43.3±5.7). Correlation analysis revealed a relationship between SCD-QSCD total and perceived likelihood of participation in HBCA for those ages 61-70 (r(263) = .222 p = .000), but not for ages 50-60 or 71-79 (r(172) = .102 p = .152; r(53) = -.102 p = .458). Our findings suggest that SCD influences the likelihood of participation in HBCA for older adults’ transitioning to old age (61-70). Findings show that for adults transitioning into old age (61-70), perceived cognitive state influences their likelihood of participation in HBCA. Importantly, concerns about CI/dementia may generate more favorable perceptions of HBCA for this group.

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