scholarly journals Using linkage analysis to identify novel gene‐gene interactions in Alzheimer’s disease

2020 ◽  
Vol 16 (S2) ◽  
Author(s):  
Michelle Grunin ◽  
Nicholas R. Wheeler ◽  
William S. Bush ◽  
Jonathan L. Haines ◽  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Linkage Analysis ◽  
Gene Interactions ◽  
Novel Gene

Linkage analysis of Alzheimer's disease with methods using relative pairs

1993 ◽  
Vol 10 (6) ◽  
pp. 377-382 ◽  
Author(s):  
Heike Blossey ◽  
Daniel Commenges ◽  
Jane M. Olson
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Linkage Analysis

The GAB2 and BDNF polymorphisms and the risk for late-onset Alzheimer's disease in an elderly Brazilian sample

2015 ◽  
Vol 27 (10) ◽  
pp. 1687-1692 ◽  
Author(s):  
Renalice Neves Vieira ◽  
Joalce Dornelas Magalhães ◽  
Jemima Sant’Anna ◽  
Mateus Massao Moriguti ◽  
Débora Marques de Miranda ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Sex Education ◽  
Multifactor Dimensionality Reduction ◽  
Late Onset ◽  
Gene Interactions ◽  
Multiple Logistic Regression ◽  
Level Of Education ◽  
Brazilian Sample ◽  
Ε4 Allele

ABSTRACTBackground:Evidences suggest that GAB2 and BDNF genes may be associated with Alzheimer's disease (AD). We aimed to investigate the GAB2 rs2373115 and BDNF rs6265 polymorphisms and the risk of AD in a Brazilian sample.Methods:269 AD patients and 114 controls were genotyped with Real-time PCR. Multifactor dimensionality reduction (MDR) was employed to explore the effects of gene–gene interactions.Results:GAB2 and BDNF were not associated with AD in our sample. Nevertheless BDNF Val allele (rs6265) presented a synergic association with the APOE ε4 allele. A multiple logistic regression demonstrated that the APOE ε4 allele and years of education were the best predictors for AD. In ε4 non-carriers sex, education and hypertension were independently correlated with AD, while in ε4 carriers we did not observe any association. The findings were further confirmed by bootstrapping method.Conclusions:Our data suggest that the interaction of BDNF and APOE has significant effect on AD. Moreover in absence of ε4, female sex, low level of education and hypertension are independently associated with AD. Interventions aimed to prevent AD should focus on these factors and also taking into account the APOE alleles.

Genetic association and linkage analysis of the apolipoprotein CII locus and familial Alzheimer's disease

1992 ◽  
Vol 31 (2) ◽  
pp. 223-227 ◽  
Author(s):  
Gerad D. Schellenberg ◽  
Michael Boehnke ◽  
Ellen M. Wijsman ◽  
Deborah K. Moore ◽  
George M. Martin ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Linkage Analysis ◽  
Genetic Association ◽  
Familial Alzheimer’S Disease ◽  
Familial Alzheimer's Disease

scholarly journals The apolipoprotein E genotyping using the PCR-RFLP was useful to linkage analysis of Alzheimer's disease families

1997 ◽  
Vol 29 (3) ◽  
pp. 161-164 ◽  
Author(s):  
Moon Ju Oh ◽  
Eun Kee Chung EK ◽  
Young Min Shin ◽  
Kyung Ok Lee ◽  
Young Suk Park
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Linkage Analysis ◽  
Apolipoprotein E ◽  
Pcr Rflp

P1-331: Familiality and linkage analysis of behavioral symptoms and age at disease onset in late-onset Alzheimer's disease

2006 ◽  
Vol 2 ◽  
pp. S194-S194 ◽  
Author(s):  
Paul Hollingworth ◽  
Marian Hamshere ◽  
Peter Holmans ◽  
Lesley Jones ◽  
Michael O'Donavan ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Linkage Analysis ◽  
Late Onset ◽  
Disease Onset ◽  
Behavioral Symptoms

A novel gene derived from a segmental duplication shows perturbed expression in Alzheimer’s disease

Neurogenetics ◽  
2007 ◽  
Vol 8 (2) ◽  
pp. 111-120 ◽  
Author(s):  
Dimitrios Avramopoulos ◽  
Ruihua Wang ◽  
David Valle ◽  
M. Daniele Fallin ◽  
Susan S. Bassett
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Segmental Duplication ◽  
Novel Gene

Combined segregation and linkage analysis of late-onset Alzheimer's disease in Duke families using Gibbs sampling

1993 ◽  
Vol 10 (6) ◽  
pp. 489-494 ◽  
Author(s):  
Cheryl Faucett ◽  
W. James Gauderman ◽  
Duncan Thomas ◽  
Al Ziogas ◽  
Eugene Sobel
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Linkage Analysis ◽  
Gibbs Sampling ◽  
Late Onset
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